Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1985 1
1987 1
1988 1
1989 1
1992 1
1994 1
1996 2
1997 3
1998 6
1999 7
2000 7
2001 13
2002 14
2003 15
2004 9
2005 8
2006 2
2007 7
2008 10
2009 3
2010 5
2011 6
2012 3
2013 8
2014 6
2015 10
2016 12
2017 7
2018 4
2019 5
2020 3
2021 4
2022 2
2023 4
2024 3
2025 1

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

180 results

Results by year

Filters applied: . Clear all
Page 1
Methyltransferase Erm(37) slips on rRNA to confer atypical resistance in Mycobacterium tuberculosis.
Madsen CT, Jakobsen L, Buriánková K, Doucet-Populaire F, Pernodet JL, Douthwaite S. Madsen CT, et al. J Biol Chem. 2005 Nov 25;280(47):38942-7. doi: 10.1074/jbc.M505727200. Epub 2005 Sep 20. J Biol Chem. 2005. PMID: 16174779 Free article.
Other methyltransferases, Erm(E) and Erm(O), maintain their specificity for A2058 on mycobacterial rRNA. Erm(E) and Erm(O) have a full-length C-terminal domain, which appears to be important for stabilizing the methyltransferases a …
Other methyltransferases, Erm(E) and Erm(O), maintain their specificity for A2058 on mycobacterial rRNA. Erm …
Macrolide resistance based on the Erm-mediated rRNA methylation.
Maravić G. Maravić G. Curr Drug Targets Infect Disord. 2004 Sep;4(3):193-202. doi: 10.2174/1568005043340777. Curr Drug Targets Infect Disord. 2004. PMID: 15379730 Review.
The most widespread mechanism of bacterial resistance to MLSB antibiotics, reported early after their introduction into clinical practice is the modification of the target site exhibited by a family of rRNA methyltransferases designated Erm. Using S-ad …
The most widespread mechanism of bacterial resistance to MLSB antibiotics, reported early after their introduction into clinical prac …
Three critical regions of the erythromycin resistance methyltransferase, ErmE, are required for function supporting a model for the interaction of Erm family enzymes with substrate rRNA.
Sharkey RE, Herbert JB, McGaha DA, Nguyen V, Schoeffler AJ, Dunkle JA. Sharkey RE, et al. RNA. 2022 Feb;28(2):210-226. doi: 10.1261/rna.078946.121. Epub 2021 Nov 18. RNA. 2022. PMID: 34795028 Free PMC article.
Recently, the first atomic-resolution structure of a ribosomal RNA adenine dimethylase (RRAD) family member bound to rRNA was solved, TFB1M bound to helix 45 of 12S rRNA. Since erythromycin resistance methyltransferases are also members of the RRAD family, an …
Recently, the first atomic-resolution structure of a ribosomal RNA adenine dimethylase (RRAD) family member bound to rRNA was solved, …
Novel inhibitors of the rRNA ErmC' methyltransferase to block resistance to macrolides, lincosamides, streptogramine B antibiotics.
Foik IP, Tuszynska I, Feder M, Purta E, Stefaniak F, Bujnicki JM. Foik IP, et al. Eur J Med Chem. 2018 Feb 25;146:60-67. doi: 10.1016/j.ejmech.2017.11.032. Epub 2018 Jan 6. Eur J Med Chem. 2018. PMID: 29396363
In erythromycin-resistant bacteria, the N6 position of A2058 in 23S rRNA is mono- or dimethylated by Erm family methyltransferases. This modification results in cross-resistance to macrolides, lincosamides and streptogramin B. Most inhibitors of Erm …
In erythromycin-resistant bacteria, the N6 position of A2058 in 23S rRNA is mono- or dimethylated by Erm family methyltrans …
Emergence of Inducible Macrolide Resistance in Mycobacterium chelonae Due to Broad-Host-Range Plasmid and Chromosomal Variants of the Novel 23S rRNA Methylase Gene, erm(55).
Brown-Elliott BA, Wallace RJ Jr, Wengenack NL, Workman SD, Cameron ADS, Bush G, Hughes MD, Melton S, Gonzalez-Ramirez B, Rodriguez E, Somayaji K, Klapperich C, Viers M, Bolaji AJ, Rempel E, Alexander DC. Brown-Elliott BA, et al. J Clin Microbiol. 2023 Jul 20;61(7):e0042823. doi: 10.1128/jcm.00428-23. Epub 2023 Jun 22. J Clin Microbiol. 2023. PMID: 37347171 Free PMC article.
Using whole-genome sequencing, we identified a novel plasmid-mediated erm gene. This gene, designated erm(55)(P), exhibits <65% amino acid identity to previously described RGM erm genes. Two additional chromosomal erm(55) alleles, with sequence iden …
Using whole-genome sequencing, we identified a novel plasmid-mediated erm gene. This gene, designated erm(55)(P), exhibits &lt …
Identification of essential residues in the Erm(B) rRNA methyltransferase of Clostridium perfringens.
Farrow KA, Lyras D, Polekhina G, Koutsis K, Parker MW, Rood JI. Farrow KA, et al. Antimicrob Agents Chemother. 2002 May;46(5):1253-61. doi: 10.1128/AAC.46.5.1253-1261.2002. Antimicrob Agents Chemother. 2002. PMID: 11959553 Free PMC article.
Macrolide-lincosamide-streptogramin B resistance is widespread, with the determinants encoding resistance to antibiotics such as erythromycin being detected in many bacterial pathogens. Resistance is most commonly mediated by the production of an Erm protein, a 23S …
Macrolide-lincosamide-streptogramin B resistance is widespread, with the determinants encoding resistance to antibiotics such as eryt …
Resistance to Macrolide Antibiotics in Public Health Pathogens.
Fyfe C, Grossman TH, Kerstein K, Sutcliffe J. Fyfe C, et al. Cold Spring Harb Perspect Med. 2016 Oct 3;6(10):a025395. doi: 10.1101/cshperspect.a025395. Cold Spring Harb Perspect Med. 2016. PMID: 27527699 Free PMC article. Review.
Macrolide resistance mechanisms can be target-based with a change in a 23S ribosomal RNA (rRNA) residue or a mutation in ribosomal protein L4 or L22 affecting the ribosome's interaction with the antibiotic. Alternatively, mono- or dimethylation of A2058 in domain V …
Macrolide resistance mechanisms can be target-based with a change in a 23S ribosomal RNA (rRNA) residue or a mutation in ribosomal pr …
A synthetic antibiotic class overcoming bacterial multidrug resistance.
Mitcheltree MJ, Pisipati A, Syroegin EA, Silvestre KJ, Klepacki D, Mason JD, Terwilliger DW, Testolin G, Pote AR, Wu KJY, Ladley RP, Chatman K, Mankin AS, Polikanov YS, Myers AG. Mitcheltree MJ, et al. Nature. 2021 Nov;599(7885):507-512. doi: 10.1038/s41586-021-04045-6. Epub 2021 Oct 27. Nature. 2021. PMID: 34707295 Free PMC article.
Here we report the structure-guided design and component-based synthesis of a rigid oxepanoproline scaffold which, when linked to the aminooctose residue of clindamycin, produces an antibiotic of exceptional potency and spectrum of activity, which we name iboxamycin. Iboxa …
Here we report the structure-guided design and component-based synthesis of a rigid oxepanoproline scaffold which, when linked to the aminoo …
Constitutive and Inducible Expression of the rRNA Methylase Gene erm(B) in Campylobacter.
Deng F, Shen J, Zhang M, Wu C, Zhang Q, Wang Y. Deng F, et al. Antimicrob Agents Chemother. 2015 Oct;59(10):6661-4. doi: 10.1128/AAC.01103-15. Epub 2015 Aug 10. Antimicrob Agents Chemother. 2015. PMID: 26259800 Free PMC article.
Macrolides are the antimicrobials of choice for treating human campylobacteriosis. The recent emergence of erm(B) in Campylobacter bacteria threatens the utility of this class of antibiotics. ...Constitutive expression of erm(B) was associated with insertion …
Macrolides are the antimicrobials of choice for treating human campylobacteriosis. The recent emergence of erm(B) in Campylobacter ba …
Plasmid-mediated drug resistance in mycobacteria: the tip of the iceberg?
Derbyshire KM, Salfinger M. Derbyshire KM, et al. J Clin Microbiol. 2023 Oct 24;61(10):e0062823. doi: 10.1128/jcm.00628-23. Epub 2023 Sep 19. J Clin Microbiol. 2023. PMID: 37724858 Free PMC article.
Resistance is mediated by point mutations in the 23S ribosomal RNA or by methylation of the rRNA by a methylase (encoded by an erm gene). Chromosomally encoded erm genes have been identified in many of the macrolide-resistant isolates, but not in Mycobacteriu …
Resistance is mediated by point mutations in the 23S ribosomal RNA or by methylation of the rRNA by a methylase (encoded by an erm …
180 results