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Year Number of Results
2005 1
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108 results

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Page 1
A comparison of the risk of QT prolongation among SSRIs.
Funk KA, Bostwick JR. Funk KA, et al. Ann Pharmacother. 2013 Oct;47(10):1330-41. doi: 10.1177/1060028013501994. Epub 2013 Oct 21. Ann Pharmacother. 2013. PMID: 24259697 Review.
DATA SYNTHESIS: Studies demonstrate possible dose-related clinically significant QT prolongation with escitalopram. Fluoxetine, fluvoxamine, and sertraline at traditional doses demonstrate a lack of clinically significant increases in QTc in the majority of studies. …
DATA SYNTHESIS: Studies demonstrate possible dose-related clinically significant QT prolongation with escitalopram. Fluoxetine …
QT Prolongation, Torsades de Pointes, and Psychotropic Medications: A 5-Year Update.
Beach SR, Celano CM, Sugrue AM, Adams C, Ackerman MJ, Noseworthy PA, Huffman JC. Beach SR, et al. Psychosomatics. 2018 Mar-Apr;59(2):105-122. doi: 10.1016/j.psym.2017.10.009. Epub 2017 Nov 3. Psychosomatics. 2018. PMID: 29275963 Review.
BACKGROUND: Some psychotropic medications have been associated with prolongation of the QT interval and QT prolongation, especially in those with medical illness, and are linked to lethal ventricular arrhythmias, such as Torsades de Pointes (TdP). ...Escit …
BACKGROUND: Some psychotropic medications have been associated with prolongation of the QT interval and QT prolongation, espec …
Meta-analysis of selective serotonin reuptake inhibitor-associated QTc prolongation.
Beach SR, Kostis WJ, Celano CM, Januzzi JL, Ruskin JN, Noseworthy PA, Huffman JC. Beach SR, et al. J Clin Psychiatry. 2014 May;75(5):e441-9. doi: 10.4088/JCP.13r08672. J Clin Psychiatry. 2014. PMID: 24922496
OBJECTIVE: To evaluate the association between selective serotonin reuptake inhibitors (SSRIs) and corrected QT interval (QTc) prolongation via meta-analysis of prospective studies. DATA SOURCES: PubMed/MEDLINE database (January 1, 1975-August 15, 2012), with additional re …
OBJECTIVE: To evaluate the association between selective serotonin reuptake inhibitors (SSRIs) and corrected QT interval (QTc) prolon …
Escitalopram in Adolescents With Generalized Anxiety Disorder: A Double-Blind, Randomized, Placebo-Controlled Study.
Strawn JR, Mills JA, Schroeder H, Mossman SA, Varney ST, Ramsey LB, Poweleit EA, Desta Z, Cecil K, DelBello MP. Strawn JR, et al. J Clin Psychiatry. 2020 Aug 25;81(5):20m13396. doi: 10.4088/JCP.20m13396. J Clin Psychiatry. 2020. PMID: 32857933 Free PMC article. Clinical Trial.
Vital signs, corrected QT interval, and adverse events were similar in patients who received escitalopram and placebo. ...Variation in CYP2C19 metabolism accounts for significant differences in escitalopram pharmacokinetics, raising the possibility that CYP2C …
Vital signs, corrected QT interval, and adverse events were similar in patients who received escitalopram and placebo. ...Vari …
Network pharmacology and molecular docking-based strategy to determine the potential mechanism for escitalopram-mediated long QT syndrome.
Zhuo C, Zhang Y, Li C, Yang L, Zhang Q, Li R, Tian H, Mao F. Zhuo C, et al. J Affect Disord. 2025 Dec 15;391:120069. doi: 10.1016/j.jad.2025.120069. Epub 2025 Aug 13. J Affect Disord. 2025. PMID: 40816370 Free article.
BACKGROUND: The objective of this study was to identify the potential molecular mechanisms for escitalopram-mediated development of long QT syndrome (LQTS) using network pharmacology and molecular docking. ...AutoDock Vina and PyMOL software were used for molecular …
BACKGROUND: The objective of this study was to identify the potential molecular mechanisms for escitalopram-mediated development of l …
Detection of Clinically Significant Drug-Drug Interactions in Fatal Torsades de Pointes: Disproportionality Analysis of the Food and Drug Administration Adverse Event Reporting System.
Ji H, Gong M, Gong L, Zhang N, Zhou R, Deng D, Yang Y, Song L, Jia Y. Ji H, et al. J Med Internet Res. 2025 Mar 25;27:e65872. doi: 10.2196/65872. J Med Internet Res. 2025. PMID: 40132181 Free PMC article.
BACKGROUND: Torsades de pointes (TdP) is a rare yet potentially fatal cardiac arrhythmia that is often drug-induced. ...The most commonly interacting drugs were amiodarone, citalopram, quetiapine, ondansetron, ciprofloxacin, methadone, escitalopram, sotalol, and vor …
BACKGROUND: Torsades de pointes (TdP) is a rare yet potentially fatal cardiac arrhythmia that is often drug-induced. ...The most comm …
Escitalopram Induced Angioedema.
Conde SL, Nazha H, Simpkins C. Conde SL, et al. Cureus. 2022 Nov 17;14(11):e31600. doi: 10.7759/cureus.31600. eCollection 2022 Nov. Cureus. 2022. PMID: 36540519 Free PMC article.
Due to QTc prolongation, her home medication of citalopram was discontinued in favor of escitalopram. Within 24 hours of administration, the patient experienced angioedema with periorbital swelling, lip swelling, and urticaria of the face and arms which was resolved with i …
Due to QTc prolongation, her home medication of citalopram was discontinued in favor of escitalopram. Within 24 hours of administrati …
Escitalopram for agitation in Alzheimer's dementia: a randomized controlled phase 3 trial.
Rajji TK, Baksh SN, Shade DM, Ismail Z, Burhan AM, Okhravi HR, Padala PR, Rosenberg PB, Schneider LS, Porsteinsson AP, Lyketsos CG; S-CitAD Research Group. Rajji TK, et al. Nat Med. 2025 May;31(5):1586-1591. doi: 10.1038/s41591-025-03569-y. Epub 2025 Mar 25. Nat Med. 2025. PMID: 40133524 Free PMC article. Clinical Trial.
In total, 173 participants were randomized (84 escitalopram versus 89 placebo; mean s.d. age = 78.4 8.7 years; 90 men (52.0%); 127 White (73.4%)). The unadjusted risk difference at 12 weeks was 0.08 (95% confidence interval: -0.21, 0.06). Drug-related QT interva …
In total, 173 participants were randomized (84 escitalopram versus 89 placebo; mean s.d. age = 78.4 8.7 years; 90 men (52.0%); 12 …
[Citalopram and QT prolongation].
Alušík Š, Paluch Z. Alušík Š, et al. Vnitr Lek. 2018 Winter;63(12):952-956. Vnitr Lek. 2018. PMID: 29334745 Review. Czech.
After analyzing the most relevant studies, the authors concluded that even papers published within the last 5 years confirmed that, of the SSRI class of drugs, citalopram prolongs the QT interval most significantly. While the QT interval prolongation in young and ot …
After analyzing the most relevant studies, the authors concluded that even papers published within the last 5 years confirmed that, of the S …
[Citalopram, escitalopram and prolonged QT: warning or alarm?].
Alvarez E, Vieira S, Garcia-Moll X. Alvarez E, et al. Rev Psiquiatr Salud Ment. 2014 Jul-Sep;7(3):147-50. doi: 10.1016/j.rpsm.2013.12.005. Epub 2014 Feb 17. Rev Psiquiatr Salud Ment. 2014. PMID: 24556340 Spanish.
The alerts issued by regulatory agencies on the potential cardiac toxicity of citalopram and escitalopram have caused alarm among clinicians. A review of the data concerning this topic shows that the alarm should be limited to patients with a history of syncope or poisonin …
The alerts issued by regulatory agencies on the potential cardiac toxicity of citalopram and escitalopram have caused alarm among cli …
108 results