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Can IL-33 and Endocan be New Markers for Retinopathy of Prematurity?
Cakir U, Tayman C, Yucel C, Ozdemir O. Cakir U, et al. Comb Chem High Throughput Screen. 2019;22(1):41-48. doi: 10.2174/1386207322666190325120244. Comb Chem High Throughput Screen. 2019. PMID: 30914019
BACKGROUND: Retinopathy of Prematurity (ROP) is a pathophysiologic condition of the retina due to abnormal proliferation of retinal vessels. OBJECTIVE: The study aimed too ascertain the importance of vascular endothelial growth factor (VEGF), insulin-like growth fac …
BACKGROUND: Retinopathy of Prematurity (ROP) is a pathophysiologic condition of the retina due to abnormal proliferation of retina …
Blood and aqueous humor phoenixin, endocan and spexin in patients with diabetes mellitus and cataract with and without diabetic retinopathy.
Celik F, Aydin S. Celik F, et al. Peptides. 2022 Apr;150:170728. doi: 10.1016/j.peptides.2021.170728. Epub 2021 Dec 28. Peptides. 2022. PMID: 34971675
Peptide phoenixin (PNX), endocan (EDC), and spexin (SPX) are associated with diabetes. Therefore, the purpose of this study was to investigate the levels of PNX, EDC and SPX in the blood and aqueous humor (AH) of patient with type 2 diabetes with and without DRP and catara …
Peptide phoenixin (PNX), endocan (EDC), and spexin (SPX) are associated with diabetes. Therefore, the purpose of this study was to in …
The angiogenic biomarker endocan is upregulated in proliferative diabetic retinopathy and correlates with vascular endothelial growth factor.
Abu El-Asrar AM, Nawaz MI, De Hertogh G, Al-Kharashi AS, Van den Eynde K, Mohammad G, Geboes K. Abu El-Asrar AM, et al. Curr Eye Res. 2015 Mar;40(3):321-31. doi: 10.3109/02713683.2014.921312. Epub 2014 May 28. Curr Eye Res. 2015. PMID: 24871583
The aim of this study was to measure the levels of endocan in the vitreous fluid from patients with proliferative diabetic retinopathy (PDR) and to correlate its levels with clinical disease activity and the levels of the angiogenic biomarkers vascular endothelial g …
The aim of this study was to measure the levels of endocan in the vitreous fluid from patients with proliferative diabetic retinop …
Endocan in prediabetes, diabetes, and diabetes-related complications: a systematic review and meta-analysis.
Khalaji A, Behnoush AH, Saeedian B, Khanmohammadi S, Shokri Varniab Z, Peiman S. Khalaji A, et al. Diabetol Metab Syndr. 2023 May 16;15(1):102. doi: 10.1186/s13098-023-01076-z. Diabetol Metab Syndr. 2023. PMID: 37189201 Free PMC article.

Moreover, in the analysis of studies with only type-2 diabetes, the same result showing higher endocan was obtained (SMD 1.01, 95% CI 0.78 to 1.24, p-value < 0.01). Higher endocan levels were also reported in chronic diabetes complications such as d

…
Moreover, in the analysis of studies with only type-2 diabetes, the same result showing higher endocan was obtained (SMD 1.01, …
Endocan and albuminuria in type 2 diabetes mellitus.
Cikrikcioglu MA, Erturk Z, Kilic E, Celik K, Ekinci I, Yasin Cetin AI, Ozkan T, Cetin G, Dae SA, Kazancioglu R, Erkoc R. Cikrikcioglu MA, et al. Ren Fail. 2016 Nov;38(10):1647-1653. doi: 10.1080/0886022X.2016.1229966. Epub 2016 Oct 18. Ren Fail. 2016. PMID: 27756187
Patients in G3 had significantly higher blood pressure but lower serum albumin and endocan levels. UACR showed a negative bivariate correlation with serum endocan levels (r = -.282, p = .001). ...CONCLUSION: Patients with macroalbuminuria had lower endocan le …
Patients in G3 had significantly higher blood pressure but lower serum albumin and endocan levels. UACR showed a negative bivariate c …
Endocan Blockade Suppresses Experimental Ocular Neovascularization in Mice.
Su T, Zhong Y, Demetriades AM, Shen J, Sui A, Yao Y, Gao Y, Zhu Y, Shen X, Xie B. Su T, et al. Invest Ophthalmol Vis Sci. 2018 Feb 1;59(2):930-939. doi: 10.1167/iovs.17-22945. Invest Ophthalmol Vis Sci. 2018. PMID: 29450540
In vitro, the effect of endocan on human retinal microvascular endothelial cell (HREC) tube formation was observed using a routine method. ...CONCLUSIONS: The current data suggest that endocan is a potential therapeutic or an additional target for retinal …
In vitro, the effect of endocan on human retinal microvascular endothelial cell (HREC) tube formation was observed using a rou …
Overexpression of miR-181a-5p inhibits retinal neovascularization through endocan and the ERK1/2 signaling pathway.
Chen X, Yao Y, Yuan F, Xie B. Chen X, et al. J Cell Physiol. 2020 Dec;235(12):9323-9335. doi: 10.1002/jcp.29733. Epub 2020 Apr 28. J Cell Physiol. 2020. PMID: 32346884 Free PMC article.
Retinal neovascularization (RNV) is a common pathological feature of angiogenesis-related retinopathy. Endocan inhibition has previously been reported to suppress RNV in oxygen-induced retinopathy (OIR); however, its molecular mechanisms remain to be e …
Retinal neovascularization (RNV) is a common pathological feature of angiogenesis-related retinopathy. Endocan inhibiti …