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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 1
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1974 1
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1980 1
1981 1
1982 1
1984 2
1985 2
1986 3
1987 3
1988 2
1989 6
1990 1
1991 6
1993 4
1994 2
1995 6
1996 3
1997 4
1998 4
1999 2
2000 7
2001 5
2002 2
2003 3
2004 4
2005 5
2006 3
2007 1
2008 1
2009 2
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112 results

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Page 1
Estradiol gel: review of the pharmacology, pharmacokinetics, efficacy, and safety in menopausal women.
Naunton M, Al Hadithy AF, Brouwers JR, Archer DF. Naunton M, et al. Menopause. 2006 May-Jun;13(3):517-27. doi: 10.1097/01.gme.0000191881.52175.8c. Menopause. 2006. PMID: 16735950 Review.
OBJECTIVE: To review the pharmacology, pharmacokinetics, safety, and efficacy of a gel containing estradiol that is applied to the skin. ...Long-term safety data of estradiol gel are required....
OBJECTIVE: To review the pharmacology, pharmacokinetics, safety, and efficacy of a gel containing estradiol that is app …
Pharmacokinetics of testosterone and estradiol gel preparations in healthy young men.
Eisenegger C, von Eckardstein A, Fehr E, von Eckardstein S. Eisenegger C, et al. Psychoneuroendocrinology. 2013 Feb;38(2):171-8. doi: 10.1016/j.psyneuen.2012.05.018. Epub 2012 Jun 19. Psychoneuroendocrinology. 2013. PMID: 22721608 Clinical Trial.
Administration of estradiol gel led to maximum estradiol serum concentration two hours after administration. ...We report here, for the first time, pharmacokinetic data on both high dose testosterone and estradiol gel application in healt …
Administration of estradiol gel led to maximum estradiol serum concentration two hours after administration. ...We repo …
Steady-state pharmacokinetics of oestradiol gel in post-menopausal women: effects of application area and washing.
Järvinen A, Granander M, Nykänen S, Laine T, Geurts P, Viitanen A. Järvinen A, et al. Br J Obstet Gynaecol. 1997 Nov;104 Suppl 16:14-8. doi: 10.1111/j.1471-0528.1997.tb11562.x. Br J Obstet Gynaecol. 1997. PMID: 9389778 Clinical Trial.
OBJECTIVE: To investigate the effect of cutaneous application area on oestradiol absorption using an oestradiol gel for transdermal use. Furthermore, the effect of washing of the application site on oestradiol pharmacokinetics was studied. DESIG …
OBJECTIVE: To investigate the effect of cutaneous application area on oestradiol absorption using an oestradiol gel for …
Assessment of estrogen exposure from transdermal estradiol gel therapy with a dried urine assay.
Newman MS, Curran DA, Mayfield BP, Saltiel D, Stanczyk FZ. Newman MS, et al. Steroids. 2022 Aug;184:109038. doi: 10.1016/j.steroids.2022.109038. Epub 2022 Apr 26. Steroids. 2022. PMID: 35483542 Free article.
Transdermal estradiol gel is a commonly used menopausal hormone therapy. In research studies investigating the pharmacokinetics and clinical utility of transdermal estradiol gels, serum is often used to measure estradiol levels. ...The primary a …
Transdermal estradiol gel is a commonly used menopausal hormone therapy. In research studies investigating the pharmacokine …
Effect of dose on the absorption of estradiol from a transdermal gel.
Järvinen A, Granander M, Laine T, Viitanen A. Järvinen A, et al. Maturitas. 2000 Apr 28;35(1):51-6. doi: 10.1016/s0378-5122(00)00101-8. Maturitas. 2000. PMID: 10802400
OBJECTIVES: To study whether dose adjustments in transdermal estradiol gel treatment would result in proportional changes in estradiol bioavailability and concentrations. ...From these concentrations, pharmacokinetic parameters for estradiol wer …
OBJECTIVES: To study whether dose adjustments in transdermal estradiol gel treatment would result in proportional changes in …
Pharmacokinetics of percutaneous estradiol: a crossover study using a gel and a transdermal system in comparison with oral micronized estradiol.
Scott RT Jr, Ross B, Anderson C, Archer DF. Scott RT Jr, et al. Obstet Gynecol. 1991 May;77(5):758-64. Obstet Gynecol. 1991. PMID: 2014092 Clinical Trial.
The pharmacokinetics of three transdermal estradiol (E2) replacement regimens were studied following establishment of steady-state dynamics. Oestrogel 3.0 mg, Oestrogel 1.5 mg, and Estraderm transdermal delivery system 4 mg (0.05 mg/day) were administered for 14 day …
The pharmacokinetics of three transdermal estradiol (E2) replacement regimens were studied following establishment of steady-s …
Pharmacokinetics of transdermal testosterone gel in hypogonadal men: application of gel at one site versus four sites: a General Clinical Research Center Study.
Wang C, Berman N, Longstreth JA, Chuapoco B, Hull L, Steiner B, Faulkner S, Dudley RE, Swerdloff RS. Wang C, et al. J Clin Endocrinol Metab. 2000 Mar;85(3):964-9. doi: 10.1210/jcem.85.3.6437. J Clin Endocrinol Metab. 2000. PMID: 10720024 Clinical Trial.
To answer this question, the pharmacokinetics of a transdermal 1% hydroalcoholic gel preparation of T was studied in nine hypogonadal men. ...Serum samples were collected for measurements of T, 5alpha dihydrotestosterone (DHT), and estradiol before, during (d …
To answer this question, the pharmacokinetics of a transdermal 1% hydroalcoholic gel preparation of T was studied in nine hypo …
Transdermal hormone therapy: gels and patches.
Samsioe G. Samsioe G. Climacteric. 2004 Dec;7(4):347-56. doi: 10.1080/13697130400012239. Climacteric. 2004. PMID: 15799606 Review.
However, as patches may be associated with local skin reactions, gel formulations have been developed in an attempt to improve acceptability and compliance with transdermal HT. Patch and gel formulations are equally as effective in treating climacteric symptoms and …
However, as patches may be associated with local skin reactions, gel formulations have been developed in an attempt to improve accept …
Long-term pharmacokinetics of transdermal testosterone gel in hypogonadal men.
Swerdloff RS, Wang C, Cunningham G, Dobs A, Iranmanesh A, Matsumoto AM, Snyder PJ, Weber T, Longstreth J, Berman N. Swerdloff RS, et al. J Clin Endocrinol Metab. 2000 Dec;85(12):4500-10. doi: 10.1210/jcem.85.12.7045. J Clin Endocrinol Metab. 2000. PMID: 11134099 Clinical Trial.
T gels have been proposed as delivery modes that minimize these problems. In this study we examined the pharmacokinetic profiles after 1, 30, 90, and 180 days of daily application of 2 doses of T gel (50 and 100 mg T in 5 and 10 g gel, delivering 5 and 10 mg …
T gels have been proposed as delivery modes that minimize these problems. In this study we examined the pharmacokinetic profiles afte …
Pharmacokinetics of a testosterone gel in healthy postmenopausal women.
Singh AB, Lee ML, Sinha-Hikim I, Kushnir M, Meikle W, Rockwood A, Afework S, Bhasin S. Singh AB, et al. J Clin Endocrinol Metab. 2006 Jan;91(1):136-44. doi: 10.1210/jc.2005-1640. Epub 2005 Nov 1. J Clin Endocrinol Metab. 2006. PMID: 16263817 Clinical Trial.
OBJECTIVE: The objective of this study was to determine the time course and profile of serum testosterone concentrations during treatment with different doses of testosterone gel in postmenopausal women and assess whether estrogen treatment affects the pharmacokinetics …
OBJECTIVE: The objective of this study was to determine the time course and profile of serum testosterone concentrations during treatment wi …
112 results