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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1966 2
1967 4
1968 5
1969 5
1970 2
1971 2
1972 4
1973 6
1974 7
1975 15
1976 11
1977 19
1978 18
1979 35
1980 37
1981 30
1982 48
1983 35
1984 38
1985 58
1986 66
1987 69
1988 77
1989 123
1990 148
1991 135
1992 156
1993 175
1994 192
1995 227
1996 264
1997 244
1998 260
1999 322
2000 364
2001 391
2002 388
2003 407
2004 393
2005 473
2006 407
2007 412
2008 427
2009 410
2010 412
2011 409
2012 385
2013 418
2014 412
2015 377
2016 386
2017 366
2018 323
2019 274
2020 307
2021 286
2022 267
2023 242
2024 269
2025 123

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11,082 results

Results by year

Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Randomized trials of estrogen-alone and breast cancer incidence: a meta-analysis.
Chlebowski RT, Aragaki AK, Pan K, Mortimer JE, Johnson KC, Wactawski-Wende J, LeBoff MS, Lavasani S, Lane D, Nelson RA, Manson JE. Chlebowski RT, et al. Breast Cancer Res Treat. 2024 Jul;206(1):177-184. doi: 10.1007/s10549-024-07307-9. Epub 2024 Apr 23. Breast Cancer Res Treat. 2024. PMID: 38653905
PURPOSE: In the Women's Health initiative (WHI) randomized clinical trial, conjugated equine estrogen (CEE)-alone significantly reduced breast cancer incidence (P = 0.005). As cohort studies had opposite findings, other randomized clinical trials were identified to conduct …
PURPOSE: In the Women's Health initiative (WHI) randomized clinical trial, conjugated equine estrogen (CEE)-alone significantly reduc …
Vaginal estrogen use in breast cancer survivors: a systematic review and meta-analysis of recurrence and mortality risks.
Beste ME, Kaunitz AM, McKinney JA, Sanchez-Ramos L. Beste ME, et al. Am J Obstet Gynecol. 2025 Mar;232(3):262-270.e1. doi: 10.1016/j.ajog.2024.10.054. Epub 2024 Nov 7. Am J Obstet Gynecol. 2025. PMID: 39521301 Review.
Lastly, there was no increase in overall mortality with use of vaginal estrogen in breast cancer survivors (5 articles 59,724, odds ratio 0.46; 95% confidence interval 0.42-0.49). CONCLUSION: The use of vaginal estrogen in patients with a history of breast cancer do …
Lastly, there was no increase in overall mortality with use of vaginal estrogen in breast cancer survivors (5 articles 59,724, odds r …
Vaginal Estrogen for the Prevention of Recurrent Urinary Tract Infection in Postmenopausal Women: A Randomized Clinical Trial.
Ferrante KL, Wasenda EJ, Jung CE, Adams-Piper ER, Lukacz ES. Ferrante KL, et al. Female Pelvic Med Reconstr Surg. 2021 Feb 1;27(2):112-117. doi: 10.1097/SPV.0000000000000749. Female Pelvic Med Reconstr Surg. 2021. PMID: 31232721 Clinical Trial.
METHODS: This was an investigator-initiated, multicenter, single-blind, randomized, placebo-controlled trial of vaginal estrogen (delivered via ring or cream) compared with placebo. Postmenopausal women with documented rUTI were randomized to receive either vaginal estr …
METHODS: This was an investigator-initiated, multicenter, single-blind, randomized, placebo-controlled trial of vaginal estrogen (del …
Estrogen therapy and breast cancer in randomized clinical trials: a narrative review.
Pan K, Lavasani S, Aragaki AK, Chlebowski RT. Pan K, et al. Menopause. 2022 Sep 1;29(9):1086-1092. doi: 10.1097/GME.0000000000002021. Epub 2022 Aug 16. Menopause. 2022. PMID: 35969882 Review.
IMPORTANCE AND OBJECTIVE: In the Women's Health Initiative (WHI) randomized trial with 10,739 postmenopausal women with prior hysterectomy, conjugated equine estrogen (CEE) alone significantly reduced breast cancer incidence and breast cancer mortality. ...After full consi …
IMPORTANCE AND OBJECTIVE: In the Women's Health Initiative (WHI) randomized trial with 10,739 postmenopausal women with prior hysterectomy, …
Estrogen for schizophrenia.
Chua WL, de Izquierdo SA, Kulkarni J, Mortimer A. Chua WL, et al. Cochrane Database Syst Rev. 2005 Oct 19;(4):CD004719. doi: 10.1002/14651858.CD004719.pub2. Cochrane Database Syst Rev. 2005. PMID: 16235377 Review.
As these vulnerable periods to psychosis are associated with estrogen withdrawal, this hormone has been proposed as a treatment for schizophrenia. OBJECTIVES: To evaluate the clinical effects of estrogens alone or in combination with progesterone, as a sole treatmen …
As these vulnerable periods to psychosis are associated with estrogen withdrawal, this hormone has been proposed as a treatment for s …
Supplementation with a Probiotic Formula Having beta-Glucuronidase Activity Modulates Serum Estrogen Levels in Healthy Peri- and Postmenopausal Women.
Honda S, Tominaga Y, Espadaler-Mazo J, Huedo P, Aguiló M, Perez M, Ueda T, Sawashita J. Honda S, et al. J Med Food. 2024 Aug;27(8):720-727. doi: 10.1089/jmf.2023.k.0320. Epub 2024 Jun 16. J Med Food. 2024. PMID: 38742994 Clinical Trial.
Declines in estrogen levels occur in women transitioning to menopause. Estrogen hormones play important roles in multiple systems of the body, and estrogen loss is associated with a variety of symptoms that can decrease quality of life. The gut microbiota is …
Declines in estrogen levels occur in women transitioning to menopause. Estrogen hormones play important roles in multiple syst …
The effect of exogenous estrogen on depressive mood in women: A systematic review and meta-analysis of randomized controlled trials.
Zhang J, Yin J, Song X, Lai S, Zhong S, Jia Y. Zhang J, et al. J Psychiatr Res. 2023 Jun;162:21-29. doi: 10.1016/j.jpsychires.2023.04.002. Epub 2023 Apr 10. J Psychiatr Res. 2023. PMID: 37068417 Review.
The finding of meta-regressions that the effect of exogenous estrogen was associated with age in perimenopause and post-menopause rather than the dose or administration of exogenous estrogen, showed again that a stable level of estrogen is more beneficial tha …
The finding of meta-regressions that the effect of exogenous estrogen was associated with age in perimenopause and post-menopause rat …
Effect of estrogen on vaginal complications of pessary use: a systematic review and meta-analysis.
Ai F, Wang Y, Wang J, Zhou L, Wang S. Ai F, et al. Climacteric. 2022 Dec;25(6):533-542. doi: 10.1080/13697137.2022.2079973. Epub 2022 Jun 13. Climacteric. 2022. PMID: 35695119
CONCLUSIONS: Local estrogen in combination with a pessary could decrease the BV rate among postmenopausal women with POP. However, consensus regarding the value of estrogen use for decreasing other pessary complications has not yet been reached. Additional multicent …
CONCLUSIONS: Local estrogen in combination with a pessary could decrease the BV rate among postmenopausal women with POP. However, co …
Bioidentical Estrogen for Menopausal Depressive Symptoms: A Systematic Review and Meta-Analysis.
Whedon JM, KizhakkeVeettil A, Rugo NA, Kieffer KA. Whedon JM, et al. J Womens Health (Larchmt). 2017 Jan;26(1):18-28. doi: 10.1089/jwh.2015.5628. Epub 2016 Sep 7. J Womens Health (Larchmt). 2017. PMID: 27603786 Review.
Small trials examining the effects of bioidentical estrogens on depressive symptoms show conflicting results. We conducted a systematic review to assess the effectiveness and safety of bioidentical estrogens for treatment of depressive symptoms in peri- and postmeno …
Small trials examining the effects of bioidentical estrogens on depressive symptoms show conflicting results. We conducted a systemat …
Estrogen-based hormone therapy in women with primary ovarian insufficiency: a systematic review.
Burgos N, Cintron D, Latortue-Albino P, Serrano V, Rodriguez Gutierrez R, Faubion S, Spencer-Bonilla G, Erwin PJ, Murad MH. Burgos N, et al. Endocrine. 2017 Dec;58(3):413-425. doi: 10.1007/s12020-017-1435-x. Epub 2017 Oct 16. Endocrine. 2017. PMID: 29039146 Free PMC article. Review.
Women with primary ovarian insufficiency (POI) have lower estrogen levels requiring hormone therapy (HT) to manage symptoms and to protect against adverse long-term health outcomes. ...The most common HT formulations were transdermal estradiol and oral conjugated equine …
Women with primary ovarian insufficiency (POI) have lower estrogen levels requiring hormone therapy (HT) to manage symptoms and to pr …
11,082 results
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