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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2000 4
2001 1
2002 2
2003 4
2004 7
2005 4
2006 5
2007 6
2008 10
2009 4
2010 2
2011 7
2012 3
2013 5
2014 9
2015 6
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136 results

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Page 1
Prevention and treatment of postmenopausal osteoporosis.
Tella SH, Gallagher JC. Tella SH, et al. J Steroid Biochem Mol Biol. 2014 Jul;142:155-70. doi: 10.1016/j.jsbmb.2013.09.008. Epub 2013 Oct 29. J Steroid Biochem Mol Biol. 2014. PMID: 24176761 Free PMC article. Review.
The sophistication of the delivery systems now allow treatment that can be given daily, weekly, monthly and annually either orally or intravenously. Bone remodeling is a dynamic process that repairs microfractures and replaces old bone with new bone. . …
The sophistication of the delivery systems now allow treatment that can be given daily, weekly, monthly and annually either orally or intrav …
Oxidative stress and inflammation: roles in osteoporosis.
Luo J, Li L, Shi W, Xu K, Shen Y, Dai B. Luo J, et al. Front Immunol. 2025 Aug 12;16:1611932. doi: 10.3389/fimmu.2025.1611932. eCollection 2025. Front Immunol. 2025. PMID: 40873591 Free PMC article. Review.
Bone homeostasis, maintained by the balance between osteoclast-mediated bone resorption and osteoblast-mediated bone formation, is regulated by various signaling pathways such as receptor activator of nuclear factor-kappaB ligand/receptor activator of nuclear …
Bone homeostasis, maintained by the balance between osteoclast-mediated bone resorption and osteoblast-mediated bone fo …
Osteoporosis Due to Hormone Imbalance: An Overview of the Effects of Estrogen Deficiency and Glucocorticoid Overuse on Bone Turnover.
Cheng CH, Chen LR, Chen KH. Cheng CH, et al. Int J Mol Sci. 2022 Jan 25;23(3):1376. doi: 10.3390/ijms23031376. Int J Mol Sci. 2022. PMID: 35163300 Free PMC article. Review.
The majority of postmenopausal women with osteoporosis have bone loss related to estrogen deficiency. The rapid bone loss results from an increase in bone turnover with an imbalance between bone resorption and bone formation. ...Estrog …
The majority of postmenopausal women with osteoporosis have bone loss related to estrogen deficiency. The rapid bone lo …
Cardenolides; calotropin and gomphogenin from Calotropis procera (Aiton) mitigate bone turnover in ovariectomized osteoporotic rats: Targeting RANKL/OPG axis and estrogen receptor-alpha.
Mettwally WSA, Hussein RA, Abdel Jaleel GA, Hassan A, Saleh DO, El-Beih AA. Mettwally WSA, et al. Fitoterapia. 2024 Dec;179:106226. doi: 10.1016/j.fitote.2024.106226. Epub 2024 Sep 23. Fitoterapia. 2024. PMID: 39321857
Molecular docking of the two compounds on ER-alpha and RANKL/OPG complex showed noteworthy binding affinities which also confirmed the supremacy of CLT due to the additional hydrogen bonding of the hydroxyl groups of the sugar moiety with RANKL/OPG com …
Molecular docking of the two compounds on ER-alpha and RANKL/OPG complex showed noteworthy binding affinities which also confi …
Bone health in estrogen-free contraception.
Hadji P, Colli E, Regidor PA. Hadji P, et al. Osteoporos Int. 2019 Dec;30(12):2391-2400. doi: 10.1007/s00198-019-05103-6. Epub 2019 Aug 24. Osteoporos Int. 2019. PMID: 31446440 Free PMC article. Review.
Estrogens and progestogens influence the bone. The major physiological effect of estrogen is the inhibition of bone resorption whereas progestogens exert activity through binding to specific progesterone receptors. ...Additionally, estrogen inhi …
Estrogens and progestogens influence the bone. The major physiological effect of estrogen is the inhibition of bone …
Mechanistic Insights and Therapeutic Strategies in Osteoporosis: A Comprehensive Review.
Elahmer NR, Wong SK, Mohamed N, Alias E, Chin KY, Muhammad N. Elahmer NR, et al. Biomedicines. 2024 Jul 23;12(8):1635. doi: 10.3390/biomedicines12081635. Biomedicines. 2024. PMID: 39200100 Free PMC article. Review.
This review synthesizes the current understanding of the pathophysiological mechanisms underlying osteoporosis, with a focus on key regulatory pathways governing osteoblast and osteoclast activities. These pathways include RANK/RANKL/OPG, Wingless-int (Wnt)/beta-cat …
This review synthesizes the current understanding of the pathophysiological mechanisms underlying osteoporosis, with a focus on key regulato …
Bone and the Immune System.
Weitzmann MN. Weitzmann MN. Toxicol Pathol. 2017 Oct;45(7):911-924. doi: 10.1177/0192623317735316. Epub 2017 Oct 18. Toxicol Pathol. 2017. PMID: 29046115 Free PMC article. Review.
Consequently, the immune system mediates powerful effects on bone turnover. Physiologically, B cells secrete osteoprotegerin (OPG), a potent anti-osteoclastogenic factor that preserves bone mass. ...Interestingly, in estrogen deficiency, activated T ce …
Consequently, the immune system mediates powerful effects on bone turnover. Physiologically, B cells secrete osteoprotegerin (OPG …
LIGHT/TNFSF14 regulates estrogen deficiency-induced bone loss.
Brunetti G, Storlino G, Oranger A, Colaianni G, Faienza MF, Ingravallo G, Di Comite M, Reseland JE, Celi M, Tarantino U, Passeri G, Ware CF, Grano M, Colucci S. Brunetti G, et al. J Pathol. 2020 Apr;250(4):440-451. doi: 10.1002/path.5385. Epub 2020 Feb 25. J Pathol. 2020. PMID: 31990039
Bone loss induced by ovariectomy is due to the direct activity on bone cells and mesenchymal cells and to the dysregulated activity of bone marrow cells, including immune cells and stromal cells, but the underlying mechanisms are not completely known. Here, w …
Bone loss induced by ovariectomy is due to the direct activity on bone cells and mesenchymal cells and to the dysregulated act …
Bone destruction in chronic otitis media is not mediated by the RANKL pathway or estrogen receptor-alpha.
Heo KW, Noh M, Hur DY, Hong TU, Park SY, Kim WJ. Heo KW, et al. Sci Prog. 2023 Jul-Sep;106(3):368504231199204. doi: 10.1177/00368504231199204. Sci Prog. 2023. PMID: 37697808 Free PMC article.
BACKGROUND: Chronic otitis media with or without cholesteatoma progresses with various degrees of bone resorption and remodeling. Estrogen mediates osteoprotective effects through the receptor activator of NF-kappaB ligand (RANKL) pathway, which is mai …
BACKGROUND: Chronic otitis media with or without cholesteatoma progresses with various degrees of bone resorption and remodeling …
The OPG/RANKL system and zinc ions are promoters of bone remodeling by osteoblast proliferation in postmenopausal osteoporosis.
Gurban CV, Mederle O. Gurban CV, et al. Rom J Morphol Embryol. 2011;52(3 Suppl):1113-9. Rom J Morphol Embryol. 2011. PMID: 22119834 Free article.
RANKL and its decoy receptor osteoprotegerin (OPG) is a mediator system involved in bone resorption and may be responsible for the homeostatic mechanism of normal bone remodeling. The serum levels of both OPG and soluble RANKL (sRA …
RANKL and its decoy receptor osteoprotegerin (OPG) is a mediator system involved in bone resorption and may be responsi …
136 results