Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1976 1
1998 1
2001 1
2006 1
2015 1
2018 1
2020 2
2021 1
2023 1
2024 2
2026 1

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

12 results

Results by year

Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
GABAergic Effects of Etifoxine and Alprazolam Assessed by Double Pulse TMS.
Riebel M, von Pappenheim B, Kanig C, Nothdurfter C, Wetter TC, Rupprecht R, Schwarzbach J. Riebel M, et al. Pharmacopsychiatry. 2023 Jul;56(4):154-161. doi: 10.1055/a-2078-4823. Epub 2023 May 23. Pharmacopsychiatry. 2023. PMID: 37220781 Clinical Trial.
RESULTS: We observed attenuation of MEPs by alprazolam but not by etifoxine. SICI was not significantly affected by alprazolam or etifoxine. However, the response pattern indicated a lowered SICI threshold after the administration of etifoxine and alprazolam …
RESULTS: We observed attenuation of MEPs by alprazolam but not by etifoxine. SICI was not significantly affected by alprazolam or …
Etifoxine is non-inferior than clonazepam for reduction of anxiety symptoms in the treatment of anxiety disorders: a randomized, double blind, non-inferiority trial.
Vicente B, Saldivia S, Hormazabal N, Bustos C, Rubí P. Vicente B, et al. Psychopharmacology (Berl). 2020 Nov;237(11):3357-3367. doi: 10.1007/s00213-020-05617-6. Epub 2020 Oct 2. Psychopharmacology (Berl). 2020. PMID: 33009629 Clinical Trial.
The experimental group received 150 mg/day of etifoxine and the control 1 mg/day of clonazepam, both in three daily doses for 12 weeks. ...The primary objective was a non-inferiority comparison between etifoxine and clonazepam in the decrease of anxiety symptoms (HA …
The experimental group received 150 mg/day of etifoxine and the control 1 mg/day of clonazepam, both in three daily doses for 12 week …
Etifoxine versus alprazolam for the treatment of adjustment disorder with anxiety: a randomized controlled trial.
Stein DJ. Stein DJ. Adv Ther. 2015 Jan;32(1):57-68. doi: 10.1007/s12325-015-0176-6. Epub 2015 Jan 27. Adv Ther. 2015. PMID: 25620535 Free PMC article. Clinical Trial.
One hundred and seventy seven patients completed the study (n = 87 in the etifoxine group; n = 90 in the alprazolam group). Etifoxine and alprazolam were accompanied by decreases in the HAM-A at day 28, with a difference between treatment groups in HAM-A score of 1. …
One hundred and seventy seven patients completed the study (n = 87 in the etifoxine group; n = 90 in the alprazolam group). Etifox …
Etifoxine impairs neither alertness nor cognitive functions of the elderly: A randomized, double-blind, placebo-controlled crossover study.
Deplanque D, Machuron F, Waucquier N, Jozefowicz E, Duhem S, Somers S, Colin O, Duhamel A, Bordet R. Deplanque D, et al. Eur Neuropsychopharmacol. 2018 Aug;28(8):925-932. doi: 10.1016/j.euroneuro.2018.05.011. Epub 2018 Jun 29. Eur Neuropsychopharmacol. 2018. PMID: 30135030 Clinical Trial.
Etifoxine hydrochloride (Stresam( )), a treatment indicated for psychosomatic manifestations of anxiety, could be an alternative to benzodiazepines. ...This study demonstrates in the elderly that a single dose of etifoxine does neither impair alertness nor any of th …
Etifoxine hydrochloride (Stresam( )), a treatment indicated for psychosomatic manifestations of anxiety, could be an alternative to b …
Dissociation of endocrine responses to the Trier Social Stress Test in Virtual Reality (VR-TSST) by the benzodiazepine alprazolam and the translocator protein 18 kDa (TSPO) ligand etifoxine.
Bahr LM, Maurer F, Weigl J, Weber K, Melchner D, Dörfelt A, Wechsler TF, Bauer O, Reinders J, Milenkovic VM, Wetzel CH, Wetter TC, Rupprecht R, Mühlberger A, Nothdurfter C. Bahr LM, et al. Psychoneuroendocrinology. 2021 Feb;124:105100. doi: 10.1016/j.psyneuen.2020.105100. Epub 2020 Dec 5. Psychoneuroendocrinology. 2021. PMID: 33338971 Clinical Trial.
METHODS: Sixty healthy males, aged between 18 and 55 years, were randomly assigned to receive either a daily dose of 1.5 mg alprazolam, 150 mg etifoxine, or placebo over five days. On the last day of intake, they were exposed to the VR-TSST. ...Due to the missing effects o …
METHODS: Sixty healthy males, aged between 18 and 55 years, were randomly assigned to receive either a daily dose of 1.5 mg alprazolam, 150 …
The translocator protein 18kDa ligand etifoxine in the treatment of depressive disorders-a double-blind, randomized, placebo-controlled proof-of-concept study.
Brunner LM, Riebel M, Wein S, Koller M, Zeman F, Huppertz G, Emmer T, Eberhardt Y, Schwarzbach J, Rupprecht R, Nothdurfter C. Brunner LM, et al. Trials. 2024 Apr 22;25(1):274. doi: 10.1186/s13063-024-08120-x. Trials. 2024. PMID: 38650030 Free PMC article. Clinical Trial.
METHODS: This is a randomized, placebo-controlled, double-blind single-center trial of 2-week treatment with the TSPO ligand etifoxine versus placebo in depressive patients. Main eligibility criteria: male or female individuals aged 18 to 65 years with unipolar/bipolar dep …
METHODS: This is a randomized, placebo-controlled, double-blind single-center trial of 2-week treatment with the TSPO ligand etifoxine …
Efficacy and safety of etifoxine versus alprazolam in generalized anxiety disorders with somatic symptoms: A randomized, double-blind, comparative study.
Prabhakar K, Ganesan G, Chaudhari D, Dalaya N, Mohide A, Thaker S, Dutta M, Patil B, Mukhopadhyay A, Neeli UJ, Kumar A, Rajendra R, Shaikh R, Saha S, Sonowal S, Behera S, Devkare P, Pandit S, Patil D, Ghadge P, Lakhwani L, Mehta S, Joglekar S. Prabhakar K, et al. J Anxiety Disord. 2026 Apr;119:103147. doi: 10.1016/j.janxdis.2026.103147. Epub 2026 Feb 25. J Anxiety Disord. 2026. PMID: 41763071 Clinical Trial.
Hence, we aimed to compare the efficacy and safety of Etifoxine with Alprazolam in adults with GAD with somatic symptoms. This phase 3, randomized, double-blind, double-dummy study included 260 patients aged 18-65 years with GAD with somatic symptoms who received either …
Hence, we aimed to compare the efficacy and safety of Etifoxine with Alprazolam in adults with GAD with somatic symptoms. This phase …
Efficacy of etifoxine compared to lorazepam monotherapy in the treatment of patients with adjustment disorders with anxiety: a double-blind controlled study in general practice.
Nguyen N, Fakra E, Pradel V, Jouve E, Alquier C, Le Guern ME, Micallef J, Blin O. Nguyen N, et al. Hum Psychopharmacol. 2006 Apr;21(3):139-49. doi: 10.1002/hup.757. Hum Psychopharmacol. 2006. PMID: 16625522 Clinical Trial.
The two drugs were equivalent on Day 28. However, more etifoxine recipients responded to the treatment (HAM-A score decreased by >or=50%, p=0.03). ...Moreover, 1 week after stopping treatment, fewer patients taking etifoxine experienced a rebound of anxiety, comp …
The two drugs were equivalent on Day 28. However, more etifoxine recipients responded to the treatment (HAM-A score decreased by > …
Local and global effects of sedation in resting-state fMRI: a randomized, placebo-controlled comparison between etifoxine and alprazolam.
Wein S, Riebel M, Seidel P, Brunner LM, Wagner V, Nothdurfter C, Rupprecht R, Schwarzbach JV. Wein S, et al. Neuropsychopharmacology. 2024 Oct;49(11):1738-1748. doi: 10.1038/s41386-024-01884-5. Epub 2024 May 31. Neuropsychopharmacology. 2024. PMID: 38822128 Free PMC article. Clinical Trial.
In a randomized double-blind repeated-measures study we compare a benzodiazepine (alprazolam) to a TSPO ligand (etifoxine) by assessing side effects and acquiring resting-state fMRI data from 34 healthy participants after 5 days of taking alprazolam, etifoxine or a …
In a randomized double-blind repeated-measures study we compare a benzodiazepine (alprazolam) to a TSPO ligand (etifoxine) by assessi …
Evaluation of the psychotropic effect of etifoxine through pursuit rotor performance and GSR.
Córsico R, Moizeszowicz J, Bursuck L, Rovaro E. Córsico R, et al. Psychopharmacologia. 1976 Feb 2;45(3):301-3. doi: 10.1007/BF00421144. Psychopharmacologia. 1976. PMID: 1250945 Clinical Trial.
Six volunteer normal subjects, aged 18-25 years, were selected from a university student population to compare the psychotropic effects of Etifoxine, d-amphetamine and placebo. All of them received Etifoxine 300 mg, d-amphetamine 5 mg and placebo in a double-blind r …
Six volunteer normal subjects, aged 18-25 years, were selected from a university student population to compare the psychotropic effects of …
12 results