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194 results

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Page 1
Stepwise assembly of the eukaryotic translation initiation factor 2 complex.
Vanselow S, Neumann-Arnold L, Wojciech-Moock F, Seufert W. Vanselow S, et al. J Biol Chem. 2022 Feb;298(2):101583. doi: 10.1016/j.jbc.2022.101583. Epub 2022 Jan 12. J Biol Chem. 2022. PMID: 35031321 Free PMC article.
The eukaryotic translation initiation factor 2 (eIF2) has key functions in the initiation step of protein synthesis. eIF2 guides the initiator tRNA to the ribosome, participates in scanning of the mRNA molecule, supports selection of the start c …
The eukaryotic translation initiation factor 2 (eIF2) has key functions in the initiation step of protein …
Termination of the integrated stress response.
De Miguel C, Thorkelsson SR, Fatalska A, Hodgson G, Dalglish M, Wang C, Bertolotti A. De Miguel C, et al. Science. 2026 Feb 19;391(6787):eadw5137. doi: 10.1126/science.adw5137. Epub 2026 Feb 19. Science. 2026. PMID: 41231936 Free PMC article.
The integrated stress response (ISR) is elicited by phosphorylation of eukaryotic translation initiation factor eIF2, which traps and inhibits rate-limiting translation factor eIF2B, thereby attenuating translation initiation …
The integrated stress response (ISR) is elicited by phosphorylation of eukaryotic translation initiation factor …
Crystal structure of eukaryotic translation initiation factor 2B.
Kashiwagi K, Takahashi M, Nishimoto M, Hiyama TB, Higo T, Umehara T, Sakamoto K, Ito T, Yokoyama S. Kashiwagi K, et al. Nature. 2016 Mar 3;531(7592):122-5. doi: 10.1038/nature16991. Epub 2016 Feb 22. Nature. 2016. PMID: 26901872
Eukaryotic cells restrict protein synthesis under various stress conditions, by inhibiting the eukaryotic translation initiation factor 2B (eIF2B). eIF2B is the guanine nucleotide exchange factor for eIF2, a heterotrimeric G protei …
Eukaryotic cells restrict protein synthesis under various stress conditions, by inhibiting the eukaryotic translation …
Eukaryotic initiation factor 2B (eIF2B).
Webb BL, Proud CG. Webb BL, et al. Int J Biochem Cell Biol. 1997 Oct;29(10):1127-31. doi: 10.1016/s1357-2725(97)00039-3. Int J Biochem Cell Biol. 1997. PMID: 9438375 Review.
Eukaryotic initiation factor 2B (eIF2B) is a guanine nucleotide-exchange factor which mediates the exchange of GDP (bound to initiation factor eIF2) for GTP, thus regenerating the active [eIF2.GTP] complex that is required f …
Eukaryotic initiation factor 2B (eIF2B) is a guanine nucleotide-exchange factor which mediates the exchan …
Surviving and Adapting to Stress: Translational Control and the Integrated Stress Response.
Wek RC, Anthony TG, Staschke KA. Wek RC, et al. Antioxid Redox Signal. 2023 Aug;39(4-6):351-373. doi: 10.1089/ars.2022.0123. Epub 2023 May 9. Antioxid Redox Signal. 2023. PMID: 36943285 Free PMC article. Review.
A primary adaptive mechanism is the integrated stress response (ISR), which features phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2 (eIF2). Four eIF2alpha kinases respond to different stresses, enabling cells to rapi …
A primary adaptive mechanism is the integrated stress response (ISR), which features phosphorylation of the alpha subunit of eukaryotic …
The phosphorylation of eukaryotic initiation factor 2: a principle of translational control in mammalian cells.
Sarre TF. Sarre TF. Biosystems. 1989;22(4):311-25. doi: 10.1016/0303-2647(89)90053-1. Biosystems. 1989. PMID: 2679904 Review.
During the initiation process, eukaryotic initiation factor 2 (eIF-2) catalyzes the binding of Met-tRNAf and GTP to the 40S ribosomal subunit. In a later step, eIF-2 is released from the ribosomal initiation complex, most likely as an eIF …
During the initiation process, eukaryotic initiation factor 2 (eIF-2) catalyzes the binding of Met-tRNAf and GTP …
A new function and complexity for protein translation initiation factor eIF2B.
Jennings MD, Pavitt GD. Jennings MD, et al. Cell Cycle. 2014;13(17):2660-5. doi: 10.4161/15384101.2014.948797. Cell Cycle. 2014. PMID: 25486352 Free PMC article. Review.
eIF2B is a multisubunit protein that is critical for protein synthesis initiation and its control. It is a guanine nucleotide exchange factor (GEF) for its GTP-binding protein partner eIF2. eIF2 binds initiator tRNA to ribosomes and promotes mRNA AUG codon recogniti …
eIF2B is a multisubunit protein that is critical for protein synthesis initiation and its control. It is a guanine nucleotide exchang …
Purification of FLAG-tagged eukaryotic initiation factor 2B complexes, subcomplexes, and fragments from Saccharomyces cerevisiae.
Mohammad-Qureshi SS, Haddad R, Palmer KS, Richardson JP, Gomez E, Pavitt GD. Mohammad-Qureshi SS, et al. Methods Enzymol. 2007;431:1-13. doi: 10.1016/S0076-6879(07)31001-X. Methods Enzymol. 2007. PMID: 17923227 Review.
The eukaryotic initiation factor 2B (eIF2B) is a five-subunit guanine nucleotide exchange factor, that functions during translation initiation to catalyze the otherwise slow exchange of GDP for GTP on its substrate eIF2. ...Here, w …
The eukaryotic initiation factor 2B (eIF2B) is a five-subunit guanine nucleotide exchange factor, that fu …
A mouse model for eukaryotic translation initiation factor 2B-leucodystrophy reveals abnormal development of brain white matter.
Geva M, Cabilly Y, Assaf Y, Mindroul N, Marom L, Raini G, Pinchasi D, Elroy-Stein O. Geva M, et al. Brain. 2010 Aug;133(Pt 8):2448-61. doi: 10.1093/brain/awq180. Brain. 2010. PMID: 20826436
Eukaryotic translation initiation factor 2B is a major housekeeping complex that governs the rate of global protein synthesis under normal and stress conditions. ...
Eukaryotic translation initiation factor 2B is a major housekeeping complex that governs the rate …
Muscle wasting in cancer.
Johns N, Stephens NA, Fearon KC. Johns N, et al. Int J Biochem Cell Biol. 2013 Oct;45(10):2215-29. doi: 10.1016/j.biocel.2013.05.032. Epub 2013 Jun 11. Int J Biochem Cell Biol. 2013. PMID: 23770121 Review.
194 results