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Did you mean eurycomanones (1 results)?
Bioavailability of Eurycomanone in Its Pure Form and in a Standardised Eurycoma longifolia Water Extract.
Ahmad N, Samiulla DS, Teh BP, Zainol M, Zolkifli NA, Muhammad A, Matom E, Zulkapli A, Abdullah NR, Ismail Z, Syed Mohamed AF. Ahmad N, et al. Pharmaceutics. 2018 Jul 11;10(3):90. doi: 10.3390/pharmaceutics10030090. Pharmaceutics. 2018. PMID: 29997335 Free PMC article.
The solubility and chemical stability of eurycomanone under the conditions of the gastrointestinal tract environment were determined. ...Both rodent models showed that eurycomanone in both the compound form and extract form had a half-life of 0.30 h. The differences …
The solubility and chemical stability of eurycomanone under the conditions of the gastrointestinal tract environment were determined. …
Production of eurycomanone from cell suspension culture of Eurycoma longifolia.
Nhan NH, Loc NH. Nhan NH, et al. Pharm Biol. 2017 Dec;55(1):2234-2239. doi: 10.1080/13880209.2017.1400077. Pharm Biol. 2017. PMID: 29130786 Free PMC article.
OBJECTIVES: Establishment of cell suspension culture of E. longifolia to determine the eurycomanone accumulation during cultures. ...DISCUSSION AND CONCLUSIONS: Cell suspension culture of E. longifolia is a suitable procedure to produce eurycomanone. The yield of …
OBJECTIVES: Establishment of cell suspension culture of E. longifolia to determine the eurycomanone accumulation during cultures. ... …
Determination of eurycomanone in rat plasma using hydrophilic interaction liquid chromatography-tandem mass spectrometry for pharmacokinetic study.
Rehman SU, Choi MS, Han YM, Kim IS, Kim SH, Piao XL, Yoo HH. Rehman SU, et al. Biomed Chromatogr. 2017 Apr;31(4). doi: 10.1002/bmc.3831. Epub 2016 Sep 26. Biomed Chromatogr. 2017. PMID: 27572280
The C(max) and AUC(0-t) , respectively, were 40.43 ± 16.08 ng/mL and 161.09 ± 37.63 ng h/mL for 10 mg/kg eurycomanone, and 9.90 ± 3.97 ng/mL and 37.15 ± 6.80 ng h/mL for E. longifolia extract (2 mg/kg as eurycomanone). The pharmacokinetic results were comparable wit …
The C(max) and AUC(0-t) , respectively, were 40.43 ± 16.08 ng/mL and 161.09 ± 37.63 ng h/mL for 10 mg/kg eurycomanone, and 9.90 ± 3.9 …
Chitosan-eurycomanone nanoformulation acts on steroidogenesis pathway genes to increase the reproduction rate in fish.
Bhat IA, Ahmad I, Mir IN, Bhat RAH, P GB, Goswami M, J K S, Sharma R. Bhat IA, et al. J Steroid Biochem Mol Biol. 2019 Jan;185:237-247. doi: 10.1016/j.jsbmb.2018.09.011. Epub 2018 Sep 22. J Steroid Biochem Mol Biol. 2019. PMID: 30253226
Chitosan-nanoconjugated eurycomanone nanoparticles with a significant particle size [130 nm (CED1); 144.1 nm (CED2)] and stable zeta potentials (+49.1 mV and +30 mV) were synthesized and evaluated against naked eurycomanone (ED1 and ED2). ...This is the first report …
Chitosan-nanoconjugated eurycomanone nanoparticles with a significant particle size [130 nm (CED1); 144.1 nm (CED2)] and stable zeta …
Isolation and lipolytic activity of eurycomanone and its epoxy derivative from Eurycoma longifolia.
Lahrita L, Hirosawa R, Kato E, Kawabata J. Lahrita L, et al. Bioorg Med Chem. 2017 Sep 1;25(17):4829-4834. doi: 10.1016/j.bmc.2017.07.032. Epub 2017 Jul 19. Bioorg Med Chem. 2017. PMID: 28760530 Free article.
Eurycomanone (1) and 13β,21-epoxyeurycomanone (2) were isolated from Eurycoma longifolia for studies of lipolytic activity. Compound 1 enhanced lipolysis in adipocytes with an EC(50) of 14.6μM, while its epoxy derivate, compound 2, had a stronger activity with an EC(50) of
Eurycomanone (1) and 13β,21-epoxyeurycomanone (2) were isolated from Eurycoma longifolia for studies of lipolytic activity. Compound
Fabrication and characterization of chitosan conjugated eurycomanone nanoparticles: In vivo evaluation of the biodistribution and toxicity in fish.
Bhat IA, Nazir MI, Ahmad I, Pathakota GB, Chanu TI, Goswami M, Sundaray JK, Sharma R. Bhat IA, et al. Int J Biol Macromol. 2018 Jun;112:1093-1103. doi: 10.1016/j.ijbiomac.2018.02.067. Epub 2018 Feb 13. Int J Biol Macromol. 2018. PMID: 29447967
The constructed nanoparticles were successfully conjugated with eurycomanone with significant entrapment efficiency. Particle size of chitosan and chitosan conjugated eurycomanone nanoparticles were 126.2nm and 130nm respectively. ...Molecular docking study revealed …
The constructed nanoparticles were successfully conjugated with eurycomanone with significant entrapment efficiency. Particle size of …
Eurycomanone induce apoptosis in HepG2 cells via up-regulation of p53.
Zakaria Y, Rahmat A, Pihie AH, Abdullah NR, Houghton PJ. Zakaria Y, et al. Cancer Cell Int. 2009 Jun 10;9:16. doi: 10.1186/1475-2867-9-16. Cancer Cell Int. 2009. PMID: 19508737 Free PMC article.
Furthermore, various methods proved that apoptosis was the mode of death in eurycomanone-treated HepG2 cells. The characteristics of apoptosis including chromatin condensation, DNA fragmentation and apoptotic bodies were found following eurycomanone treatment. This …
Furthermore, various methods proved that apoptosis was the mode of death in eurycomanone-treated HepG2 cells. The characteristics of …
Eurycomanone suppresses expression of lung cancer cell tumor markers, prohibitin, annexin 1 and endoplasmic reticulum protein 28.
Wong PF, Cheong WF, Shu MH, Teh CH, Chan KL, AbuBakar S. Wong PF, et al. Phytomedicine. 2012 Jan 15;19(2):138-44. doi: 10.1016/j.phymed.2011.07.001. Epub 2011 Sep 7. Phytomedicine. 2012. PMID: 21903368
Eurycomanone inhibited A549 lung cancer cell proliferation in a dose-dependent manner at concentrations ranging from 5 to 20 μg/ml. ...The anti-proliferative effects were not fully reversible following the removal of eurycomanone, in which 30% of cell inhibition sti
Eurycomanone inhibited A549 lung cancer cell proliferation in a dose-dependent manner at concentrations ranging from 5 to 20 μg/ml. .
Antiadipogenic effects of a standardized quassinoids-enriched fraction and eurycomanone from Eurycoma longifolia.
Balan D, Chan KL, Murugan D, AbuBakar S, Wong PF. Balan D, et al. Phytother Res. 2018 Jul;32(7):1332-1345. doi: 10.1002/ptr.6065. Epub 2018 Mar 9. Phytother Res. 2018. PMID: 29520860
This study sought to investigate the effects of an EL standardized quassinoids-enriched fraction (SQEL) and the pure compound, eurycomanone, on adipogenesis in 3T3-L1 preadipocyte cells. 3T3-L1 cells were induced to differentiate and treated for 8 days. ...
This study sought to investigate the effects of an EL standardized quassinoids-enriched fraction (SQEL) and the pure compound, eurycomano
Eurycomanone, the major quassinoid in Eurycoma longifolia root extract increases spermatogenesis by inhibiting the activity of phosphodiesterase and aromatase in steroidogenesis.
Low BS, Choi SB, Abdul Wahab H, Das PK, Chan KL. Low BS, et al. J Ethnopharmacol. 2013 Aug 26;149(1):201-7. doi: 10.1016/j.jep.2013.06.023. Epub 2013 Jun 27. J Ethnopharmacol. 2013. PMID: 23810842
AIM OF THE STUDY: To provide evidences on the plant ethnopharmacological use and the involvement of eurycomanone, the major indigenous plant quassinoid in testosterone steroidogenesis and spermatogenesis increase. ...Eurycomanone and the standard steroidogenesis inh …
AIM OF THE STUDY: To provide evidences on the plant ethnopharmacological use and the involvement of eurycomanone, the major indigenou …
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