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Long-term treatment of epilepsy with everolimus in tuberous sclerosis.
Krueger DA, Wilfong AA, Mays M, Talley CM, Agricola K, Tudor C, Capal J, Holland-Bouley K, Franz DN. Krueger DA, et al. Neurology. 2016 Dec 6;87(23):2408-2415. doi: 10.1212/WNL.0000000000003400. Epub 2016 Nov 4. Neurology. 2016. PMID: 27815402 Free PMC article. Clinical Trial.
OBJECTIVE: To evaluate the long-term benefit and safety of everolimus for the treatment of medically refractory epilepsy in patients with tuberous sclerosis complex (TSC). ...Long-term treatment with everolimus is safe and well-tolerated in this popula …
OBJECTIVE: To evaluate the long-term benefit and safety of everolimus for the treatment of medically refractory epilepsy in pa …
Short-term safety of mTOR inhibitors in infants and very young children with tuberous sclerosis complex (TSC): Multicentre clinical experience.
Krueger DA, Capal JK, Curatolo P, Devinsky O, Ess K, Tzadok M, Koenig MK, Narayanan V, Ramos F, Jozwiak S, de Vries P, Jansen AC, Wong M, Mowat D, Lawson J, Bruns S, Franz DN; TSCure Research Group. Krueger DA, et al. Eur J Paediatr Neurol. 2018 Nov;22(6):1066-1073. doi: 10.1016/j.ejpn.2018.06.007. Epub 2018 Jul 4. Eur J Paediatr Neurol. 2018. PMID: 30005812
RESULTS: 19 of 52 (37%) TSC Centres reported treatment of at least one child with TSC under the age of two years with everolimus or sirolimus. ...CONCLUSIONS: Everolimus, and to a lesser extent sirolimus, are increasingly being used to treat TSC
RESULTS: 19 of 52 (37%) TSC Centres reported treatment of at least one child with TSC under the age of two years with evero
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