Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer's mouse model.
Choi SH, Bylykbashi E, Chatila ZK, Lee SW, Pulli B, Clemenson GD, Kim E, Rompala A, Oram MK, Asselin C, Aronson J, Zhang C, Miller SJ, Lesinski A, Chen JW, Kim DY, van Praag H, Spiegelman BM, Gage FH, Tanzi RE.
Choi SH, et al.
Science. 2018 Sep 7;361(6406):eaan8821. doi: 10.1126/science.aan8821.
Science. 2018.
PMID: 30190379
Free PMC article.
Adult hippocampal neurogenesis (AHN) is impaired before the onset of Alzheimer's disease (AD) pathology. We found that exercise provided cognitive benefit to 5 FAD mice, a mouse model of AD, by inducing AHN and elevating levels of brain-derived neurotrophic factor ( …
Adult hippocampal neurogenesis (AHN) is impaired before the onset of Alzheimer's disease (AD) pathology. We found that exercise …