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Engineering exosomes for targeted drug delivery.
Liang Y, Duan L, Lu J, Xia J. Liang Y, et al. Theranostics. 2021 Jan 1;11(7):3183-3195. doi: 10.7150/thno.52570. eCollection 2021. Theranostics. 2021. PMID: 33537081 Free PMC article. Review.
Exosomes are cell-derived nanovesicles that are involved in the intercellular transportation of materials. ...Here, we present a detailed review of exosomes engineering through genetic and chemical methods for targeted drug delivery. Although still in its infancy, …
Exosomes are cell-derived nanovesicles that are involved in the intercellular transportation of materials. ...Here, we present a deta …
Exosomes.
Pegtel DM, Gould SJ. Pegtel DM, et al. Annu Rev Biochem. 2019 Jun 20;88:487-514. doi: 10.1146/annurev-biochem-013118-111902. Annu Rev Biochem. 2019. PMID: 31220978 Review.
Exosome biogenesis is a mechanism of protein quality control, and once released, exosomes have activities as diverse as remodeling the extracellular matrix and transmitting signals and molecules to other cells. ...On the basis of these and other properties, exoso …
Exosome biogenesis is a mechanism of protein quality control, and once released, exosomes have activities as diverse as remode …
The Machinery of Exosomes: Biogenesis, Release, and Uptake.
Krylova SV, Feng D. Krylova SV, et al. Int J Mol Sci. 2023 Jan 10;24(2):1337. doi: 10.3390/ijms24021337. Int J Mol Sci. 2023. PMID: 36674857 Free PMC article. Review.
Additionally, delivery of exosomes and exosomal miRNA has already been shown to improve systemic metabolism and inhibit progression of cancer development in mice. However, the subcellular machinery of exosomes, including their biogenesis, release and uptake, …
Additionally, delivery of exosomes and exosomal miRNA has already been shown to improve systemic metabolism and inhibit progre …
Mesenchymal Stem Cell-Derived Exosomes: Applications in Regenerative Medicine.
Hade MD, Suire CN, Suo Z. Hade MD, et al. Cells. 2021 Aug 1;10(8):1959. doi: 10.3390/cells10081959. Cells. 2021. PMID: 34440728 Free PMC article. Review.
The favorable biological properties of exosomes including biocompatibility, stability, low toxicity, and proficient exchange of molecular cargos make exosomes prime candidates for tissue engineering and regenerative medicine. ...In this review, we summarize the curr …
The favorable biological properties of exosomes including biocompatibility, stability, low toxicity, and proficient exchange of molec …
Exosomes: Large-scale production, isolation, drug loading efficiency, and biodistribution and uptake.
Kimiz-Gebologlu I, Oncel SS. Kimiz-Gebologlu I, et al. J Control Release. 2022 Jul;347:533-543. doi: 10.1016/j.jconrel.2022.05.027. Epub 2022 May 24. J Control Release. 2022. PMID: 35597405 Review.
Exosomes are nanovesicles with different contents that play a role in various biological and pathological processes. ...For this purpose, methodologies for the large-scale production of exosomes, exosome isolation, exosomal cargo loading, and exosom …
Exosomes are nanovesicles with different contents that play a role in various biological and pathological processes. ...For this purp …
Using exosomes, naturally-equipped nanocarriers, for drug delivery.
Batrakova EV, Kim MS. Batrakova EV, et al. J Control Release. 2015 Dec 10;219:396-405. doi: 10.1016/j.jconrel.2015.07.030. Epub 2015 Aug 1. J Control Release. 2015. PMID: 26241750 Free PMC article. Review.
Exosomes offer distinct advantages that uniquely position them as highly effective drug carriers. ...Development and validation of exosome-based drug delivery systems are the focus of this review. Different techniques of exosome isolation, characterization, d …
Exosomes offer distinct advantages that uniquely position them as highly effective drug carriers. ...Development and validation of …
Exosomes as miRNA Carriers: Formation-Function-Future.
Yu X, Odenthal M, Fries JW. Yu X, et al. Int J Mol Sci. 2016 Dec 2;17(12):2028. doi: 10.3390/ijms17122028. Int J Mol Sci. 2016. PMID: 27918449 Free PMC article. Review.
Exosomes, which are one of the smallest extracellular vesicles released from cells, have been shown to carry different nucleic acids, including microRNAs (miRNAs). miRNAs significantly regulate cell growth and metabolism by posttranscriptional inhibition of gene expression …
Exosomes, which are one of the smallest extracellular vesicles released from cells, have been shown to carry different nucleic acids, …
Surface functionalization of exosomes for target-specific delivery and in vivo imaging & tracking: Strategies and significance.
Salunkhe S, Dheeraj, Basak M, Chitkara D, Mittal A. Salunkhe S, et al. J Control Release. 2020 Oct 10;326:599-614. doi: 10.1016/j.jconrel.2020.07.042. Epub 2020 Jul 28. J Control Release. 2020. PMID: 32730952 Review.
Surface modification of exosomes imparts additional functionality to the exosomes to enable site specific drug delivery and in vivo imaging and tracking and is an emerging area in drug delivery research. ...The specific exosomal membrane proteins such as tetr …
Surface modification of exosomes imparts additional functionality to the exosomes to enable site specific drug delivery and in …
Cancer-Derived Exosomes: Their Role in Cancer Biology and Biomarker Development.
Kok VC, Yu CC. Kok VC, et al. Int J Nanomedicine. 2020 Oct 19;15:8019-8036. doi: 10.2147/IJN.S272378. eCollection 2020. Int J Nanomedicine. 2020. PMID: 33116515 Free PMC article. Review.
Exosomes are a subset of tiny extracellular vesicles manufactured by all cells and are present in all body fluids. ...Thus, exosomes are being exploited in diagnostic biomarker development, with its potential in clinical applications as therapeutic targets utilized …
Exosomes are a subset of tiny extracellular vesicles manufactured by all cells and are present in all body fluids. ...Thus, exosom …
Isolation and characterization of RNA-containing exosomes.
Lässer C, Eldh M, Lötvall J. Lässer C, et al. J Vis Exp. 2012 Jan 9;(59):e3037. doi: 10.3791/3037. J Vis Exp. 2012. PMID: 22257828 Free PMC article.
Further, we have also shown that exosomes derived from cells grown under oxidative stress can induce tolerance against further stress in recipient cells and thus suggest a biological function of the exosomal shuttle RNA. ...Important methods to identify the exoso …
Further, we have also shown that exosomes derived from cells grown under oxidative stress can induce tolerance against further stress …
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