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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 6
1946 12
1947 18
1948 29
1949 50
1950 56
1951 81
1952 70
1953 72
1954 75
1955 64
1956 108
1957 60
1958 91
1959 83
1960 102
1961 150
1962 123
1963 189
1964 202
1965 197
1966 173
1967 213
1968 227
1969 283
1970 512
1971 567
1972 505
1973 430
1974 372
1975 359
1976 362
1977 306
1978 290
1979 263
1980 269
1981 290
1982 302
1983 371
1984 473
1985 490
1986 575
1987 721
1988 670
1989 775
1990 918
1991 849
1992 897
1993 1032
1994 971
1995 1045
1996 1060
1997 1281
1998 1289
1999 1577
2000 1755
2001 1707
2002 1935
2003 2210
2004 2111
2005 2304
2006 2704
2007 2818
2008 3043
2009 3341
2010 3603
2011 3820
2012 4046
2013 4216
2014 4288
2015 4596
2016 4803
2017 4970
2018 4934
2019 5200
2020 5760
2021 5746
2022 5668
2023 5587
2024 5782
2025 5847
2026 2912

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114,813 results

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Page 1
Manganese-Induced Parkinsonism: Evidence from Epidemiological and Experimental Studies.
Lucchini R, Tieu K. Lucchini R, et al. Biomolecules. 2023 Jul 30;13(8):1190. doi: 10.3390/biom13081190. Biomolecules. 2023. PMID: 37627255 Free PMC article. Review.
This change of exposure paradigm has prompted numerous epidemiological investigations of the occurrence of Parkinson's disease (PD), or parkinsonism, due to the long-term impact of Mn. In parallel, experimental research has focused on the underlying pathogenic mecha …
This change of exposure paradigm has prompted numerous epidemiological investigations of the occurrence of Parkinson's disease (PD), or p …
Experimental parkinsonism in primates.
Matsumura M. Matsumura M. Stereotact Funct Neurosurg. 2001;77(1-4):91-7. doi: 10.1159/000064603. Stereotact Funct Neurosurg. 2001. PMID: 12378063 Review.
In the 1980s, a dopaminergic neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) was accidentally shown to induce parkinsonism in humans, and subsequently was confirmed to reproduce an almost perfect model of parkinsonism in primates. In the late 1980s c …
In the 1980s, a dopaminergic neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) was accidentally shown to induce parkinsonis …
Spinal cord and parkinsonism: neuromorphological evidences in humans and experimental studies.
Vivacqua G, Casini A, Vaccaro R, Salvi EP, Pasquali L, Fornai F, Yu S, D'Este L. Vivacqua G, et al. J Chem Neuroanat. 2011 Dec;42(4):327-40. doi: 10.1016/j.jchemneu.2011.03.001. Epub 2011 Mar 22. J Chem Neuroanat. 2011. PMID: 21392570 Review.
The involvement of the spinal cord in parkinsonism is becoming more and more evident based on human autopsies and on experimental models, obtained using specific neurotoxins or genetic manipulations. Besides Parkinson disease, other degenerative disorders cha …
The involvement of the spinal cord in parkinsonism is becoming more and more evident based on human autopsies and on experimental …
Rotenone, paraquat, and Parkinson's disease.
Tanner CM, Kamel F, Ross GW, Hoppin JA, Goldman SM, Korell M, Marras C, Bhudhikanok GS, Kasten M, Chade AR, Comyns K, Richards MB, Meng C, Priestley B, Fernandez HH, Cambi F, Umbach DM, Blair A, Sandler DP, Langston JW. Tanner CM, et al. Environ Health Perspect. 2011 Jun;119(6):866-72. doi: 10.1289/ehp.1002839. Epub 2011 Jan 26. Environ Health Perspect. 2011. PMID: 21269927 Free PMC article.
BACKGROUND: Mitochondrial dysfunction and oxidative stress are pathophysiologic mechanisms implicated in experimental models and genetic forms of Parkinson's disease (PD). Certain pesticides may affect these mechanisms, but no pesticide has been definitively associated wit …
BACKGROUND: Mitochondrial dysfunction and oxidative stress are pathophysiologic mechanisms implicated in experimental models and gene …
Haloperidol-induced catalepsy as an animal model for parkinsonism: A systematic review of experimental studies.
Waku I, Magalhães MS, Alves CO, de Oliveira AR. Waku I, et al. Eur J Neurosci. 2021 Jun;53(11):3743-3767. doi: 10.1111/ejn.15222. Epub 2021 Apr 25. Eur J Neurosci. 2021. PMID: 33818841
Several useful animal models for parkinsonism have been developed so far. Haloperidol-induced catalepsy is often used as a rodent model for the study of motor impairments observed in Parkinson's disease and related disorders and for the screening of potential antipa …
Several useful animal models for parkinsonism have been developed so far. Haloperidol-induced catalepsy is often used as a rodent mod …
Serum neuronal exosomes predict and differentiate Parkinson's disease from atypical parkinsonism.
Jiang C, Hopfner F, Katsikoudi A, Hein R, Catli C, Evetts S, Huang Y, Wang H, Ryder JW, Kuhlenbaeumer G, Deuschl G, Padovani A, Berg D, Borroni B, Hu MT, Davis JJ, Tofaris GK. Jiang C, et al. J Neurol Neurosurg Psychiatry. 2020 Jul;91(7):720-729. doi: 10.1136/jnnp-2019-322588. Epub 2020 Apr 9. J Neurol Neurosurg Psychiatry. 2020. PMID: 32273329 Free PMC article.
Currently, there is no blood test to predict the underlying pathology or distinguish Parkinson's from atypical parkinsonian syndromes. We assessed the clinical utility of serum neuronal exosomes as biomarkers across the spectrum of Parkinson's disease, multiple system atro …
Currently, there is no blood test to predict the underlying pathology or distinguish Parkinson's from atypical parkinsonian syndromes …
Parkinsonism and dementia.
Koros C, Stefanis L, Scarmeas N. Koros C, et al. J Neurol Sci. 2022 Feb 15;433:120015. doi: 10.1016/j.jns.2021.120015. Epub 2021 Oct 2. J Neurol Sci. 2022. PMID: 34642023 Review.
The aim of the present review is to summarize literature data on dementia in parkinsonian disorders. Cognitive decline and the gradual development of dementia are considered to be key features in the majority of parkinsonian conditions. ...This article is par …
The aim of the present review is to summarize literature data on dementia in parkinsonian disorders. Cognitive decline and the …
Protective role of mitophagy on microglia-mediated neuroinflammatory injury through mtDNA-STING signaling in manganese-induced parkinsonism.
Lu Y, Gao L, Yang Y, Shi D, Zhang Z, Wang X, Huang Y, Wu J, Meng J, Li H, Yan D. Lu Y, et al. J Neuroinflammation. 2025 Feb 28;22(1):55. doi: 10.1186/s12974-025-03396-5. J Neuroinflammation. 2025. PMID: 40022162 Free PMC article.
However, the precise role of microglial mitophagy in modulating neuroinflammation in Mn-induced parkinsonism and its underlying molecular mechanism remains unclear. Here, we observed that Mn-exposed mice exhibited neurobehavioral abnormalities and detrimental microglial ac …
However, the precise role of microglial mitophagy in modulating neuroinflammation in Mn-induced parkinsonism and its underlying molec …
Experimental Parkinsonism induced by tetanus toxin injected into basal ganglia.
Meglić P, Šoštarić P, Virag D, Knezović A, Habek N, Rossetto O, Matak I. Meglić P, et al. Br J Pharmacol. 2025 Sep;182(18):4400-4418. doi: 10.1111/bph.70079. Epub 2025 Jun 4. Br J Pharmacol. 2025. PMID: 40467446
EXPERIMENTAL APPROACH: Rats were injected with low-dose TeNT unilaterally into globus pallidus internus (GPi, 0.4-ng TeNT), substantia nigra (SN, 0.4-ng TeNT) or caudate putamen (CPu, 0.1-, 0.4- and 0.8-ng TeNT). ...CONCLUSION AND IMPLICATIONS: Tetanus toxin injected into …
EXPERIMENTAL APPROACH: Rats were injected with low-dose TeNT unilaterally into globus pallidus internus (GPi, 0.4-ng TeNT), substanti …
114,813 results
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