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Year Number of Results
1913 1
1936 1
1939 2
1940 1
1941 1
1944 1
1945 2
1946 8
1947 6
1948 7
1949 7
1950 6
1951 17
1952 10
1953 17
1954 18
1955 17
1956 11
1957 10
1958 21
1959 16
1960 14
1961 13
1962 16
1963 19
1964 24
1965 15
1966 8
1967 4
1968 9
1969 5
1970 11
1971 11
1972 8
1973 14
1974 17
1975 45
1976 47
1977 54
1978 63
1979 95
1980 110
1981 161
1982 264
1983 319
1984 414
1985 610
1986 817
1987 858
1988 974
1989 1349
1990 1361
1991 1463
1992 1561
1993 1655
1994 2046
1995 2085
1996 2451
1997 2645
1998 2800
1999 2821
2000 3258
2001 3368
2002 3642
2003 3693
2004 4335
2005 4649
2006 5097
2007 5227
2008 5584
2009 6062
2010 6894
2011 7376
2012 8193
2013 8767
2014 9428
2015 9914
2016 10289
2017 10993
2018 11518
2019 12362
2020 14210
2021 15837
2022 16305
2023 17081
2024 18391
2025 12042
2026 30

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236,115 results

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Page 1
Early-onset familial Alzheimer's disease (EOFAD).
Wu L, Rosa-Neto P, Hsiung GY, Sadovnick AD, Masellis M, Black SE, Jia J, Gauthier S. Wu L, et al. Can J Neurol Sci. 2012 Jul;39(4):436-45. doi: 10.1017/s0317167100013949. Can J Neurol Sci. 2012. PMID: 22728850 Review.

Early-onset familial Alzheimer's disease (EOFAD) is a condition characterized by early onset dementia (age at onset < 65 years) and a positive family history for dementia. ...The mutations within these three genes (PS1/PS2/APP) affect a common patho

…
Early-onset familial Alzheimer's disease (EOFAD) is a condition characterized by early onset dementia (age at on …
Alzheimer's disease: genes, proteins, and therapy.
Selkoe DJ. Selkoe DJ. Physiol Rev. 2001 Apr;81(2):741-66. doi: 10.1152/physrev.2001.81.2.741. Physiol Rev. 2001. PMID: 11274343 Free article. Review.
Rapid progress in deciphering the biological mechanism of Alzheimer's disease (AD) has arisen from the application of molecular and cell biology to this complex disorder of the limbic and association cortices. In turn, new insights into fundamental aspects of …
Rapid progress in deciphering the biological mechanism of Alzheimer's disease (AD) has arisen from the application of m …
Alzheimer's disease.
Blennow K, de Leon MJ, Zetterberg H. Blennow K, et al. Lancet. 2006 Jul 29;368(9533):387-403. doi: 10.1016/S0140-6736(06)69113-7. Lancet. 2006. PMID: 16876668 Review.
However, as our knowledge increases so does our appreciation for the pathogenic complexity of the disorder. Familial Alzheimer's disease is a very rare autosomal dominant disease with early onset, caused by mutations in the amyloid precursor pro …
However, as our knowledge increases so does our appreciation for the pathogenic complexity of the disorder. Familial Alzheimer …
Dysfunctional gamma-Secretase in Familial Alzheimer's Disease.
Wolfe MS. Wolfe MS. Neurochem Res. 2019 Jan;44(1):5-11. doi: 10.1007/s11064-018-2511-1. Epub 2018 Apr 4. Neurochem Res. 2019. PMID: 29619615 Free PMC article. Review.
Genetics strongly implicate the amyloid beta-peptide (Abeta) in the pathogenesis of Alzheimer's disease. Dominant missense mutation in the presenilins and the amyloid precursor protein (APP) cause early-onset familial Alzheimer's disea …
Genetics strongly implicate the amyloid beta-peptide (Abeta) in the pathogenesis of Alzheimer's disease. Dominant misse …
Rodent models for Alzheimer's disease drug discovery.
Puzzo D, Gulisano W, Palmeri A, Arancio O. Puzzo D, et al. Expert Opin Drug Discov. 2015 Jul;10(7):703-11. doi: 10.1517/17460441.2015.1041913. Epub 2015 Apr 30. Expert Opin Drug Discov. 2015. PMID: 25927677 Free PMC article. Review.
INTRODUCTION: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory loss and personality changes, leading to dementia. Histopathological hallmarks are represented by aggregates of beta-amyloid peptide (Abeta) in senile plaques and d …
INTRODUCTION: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory loss and personality cha …
Neuronal gamma-secretase regulates lipid metabolism, linking cholesterol to synaptic dysfunction in Alzheimer's disease.
Essayan-Perez S, Südhof TC. Essayan-Perez S, et al. Neuron. 2023 Oct 18;111(20):3176-3194.e7. doi: 10.1016/j.neuron.2023.07.005. Epub 2023 Aug 4. Neuron. 2023. PMID: 37543038 Free PMC article.
Presenilin mutations that alter gamma-secretase activity cause familial Alzheimer's disease (AD), whereas ApoE4, an apolipoprotein for cholesterol transport, predisposes to sporadic AD. Both sporadic and familial AD feature synaptic dysfunction. …
Presenilin mutations that alter gamma-secretase activity cause familial Alzheimer's disease (AD), whereas ApoE4, …
Plasma biomarkers predict Alzheimer's disease before clinical onset in Chinese cohorts.
Cai H, Pang Y, Fu X, Ren Z, Jia L. Cai H, et al. Nat Commun. 2023 Oct 24;14(1):6747. doi: 10.1038/s41467-023-42596-6. Nat Commun. 2023. PMID: 37875471 Free PMC article.
Plasma amyloid-beta (Abeta)42, phosphorylated tau (p-tau)181, and neurofilament light chain (NfL) are promising biomarkers of Alzheimer's disease (AD). However, whether these biomarkers can predict AD in Chinese populations is yet to be fully explored. ...The …
Plasma amyloid-beta (Abeta)42, phosphorylated tau (p-tau)181, and neurofilament light chain (NfL) are promising biomarkers of Alzheimer …
Mechanisms of neurodegeneration - Insights from familial Alzheimer's disease.
Chávez-Gutiérrez L, Szaruga M. Chávez-Gutiérrez L, et al. Semin Cell Dev Biol. 2020 Sep;105:75-85. doi: 10.1016/j.semcdb.2020.03.005. Epub 2020 May 14. Semin Cell Dev Biol. 2020. PMID: 32418657 Review.
The rising prevalence of Alzheimer's disease (AD), together with the lack of effective treatments, portray it as one of the major health challenges of our times. ...Genetics has provided invaluable clues to the genesis of the disease by revealing deter …
The rising prevalence of Alzheimer's disease (AD), together with the lack of effective treatments, portray it as one of …
Familial Alzheimer's Disease and Recessive Modifiers.
Vélez JI, Lopera F, Silva CT, Villegas A, Espinosa LG, Vidal OM, Mastronardi CA, Arcos-Burgos M. Vélez JI, et al. Mol Neurobiol. 2020 Feb;57(2):1035-1043. doi: 10.1007/s12035-019-01798-0. Epub 2019 Oct 29. Mol Neurobiol. 2020. PMID: 31664702 Free PMC article.
Alzheimer's disease (AD) is progressive brain disorder that affects ~ 50 million people worldwide and has no current effective treatment. ...
Alzheimer's disease (AD) is progressive brain disorder that affects ~ 50 million people worldwide and has no current ef …
Familial Alzheimer's disease.
Bird TD. Bird TD. Ann Neurol. 1994 Sep;36(3):335-6. doi: 10.1002/ana.410360303. Ann Neurol. 1994. PMID: 8080240 No abstract available.
236,115 results
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