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Farnesyl pyrophosphate synthase is the molecular target of nitrogen-containing bisphosphonates.
van Beek E, Pieterman E, Cohen L, Löwik C, Papapoulos S. van Beek E, et al. Biochem Biophys Res Commun. 1999 Oct 14;264(1):108-11. doi: 10.1006/bbrc.1999.1499. Biochem Biophys Res Commun. 1999. PMID: 10527849
Bisphosphonates (Bps), inhibitors of osteoclastic bone resorption, are used in the treatment of skeletal disorders. Recent evidence indicated that farnesyl pyrophosphate (FPP) synthase and/or isopentenyl pyrophosphate (IPP) isomerase is the intracellul …
Bisphosphonates (Bps), inhibitors of osteoclastic bone resorption, are used in the treatment of skeletal disorders. Recent evidence i …
Minodronate for the treatment of osteoporosis.
Ohishi T, Matsuyama Y. Ohishi T, et al. Ther Clin Risk Manag. 2018 Apr 17;14:729-739. doi: 10.2147/TCRM.S149236. eCollection 2018. Ther Clin Risk Manag. 2018. PMID: 29713181 Free PMC article. Review.
The mechanism of action for suppressing bone resorption is the inhibition of farnesyl pyrophosphate synthase, a key enzyme in the mevalonic acid metabolic pathway of osteoclasts, to induce apoptosis of the cells. ...
The mechanism of action for suppressing bone resorption is the inhibition of farnesyl pyrophosphate synthase, a key enz …
Bisphosphonates: Future perspective for neurological disorders.
Zameer S, Najmi AK, Vohora D, Akhtar M. Zameer S, et al. Pharmacol Rep. 2018 Oct;70(5):900-907. doi: 10.1016/j.pharep.2018.03.011. Epub 2018 Mar 30. Pharmacol Rep. 2018. PMID: 30096489 Review.
Neurodegenerative disorders and osteoporosis share some common underlying pathological features including calcium overload, accumulation of toxic chemicals, inflammation and impaired protein prenylation by isoprenoids (farnesyl pyrophosphate and geranylgeranyl pyrop …
Neurodegenerative disorders and osteoporosis share some common underlying pathological features including calcium overload, accumulation of …
Small interfering RNA knocks down the molecular target of alendronate, farnesyl pyrophosphate synthase, in osteoclast and osteoblast cultures.
Wang Y, Panasiuk A, Grainger DW. Wang Y, et al. Mol Pharm. 2011 Aug 1;8(4):1016-24. doi: 10.1021/mp100374n. Epub 2011 Jan 21. Mol Pharm. 2011. PMID: 21186792 Free PMC article.
Farnesyl pyrophosphate synthase (FPPS), an enzyme in the mevalonate pathway, is the inhibition target of alendronate, a potent FDA-approved nitrogen-containing bisphosphonate (N-BP) drug, at the molecular level. Alendronate not only inhibits osteoclasts …
Farnesyl pyrophosphate synthase (FPPS), an enzyme in the mevalonate pathway, is the inhibition target of alendronate, a …
Bisphosphonates: from bench to bedside.
Russell RG. Russell RG. Ann N Y Acad Sci. 2006 Apr;1068:367-401. doi: 10.1196/annals.1346.041. Ann N Y Acad Sci. 2006. PMID: 16831938 Review.
Bisphosphonates inhibit bone resorption by being selectively taken up and adsorbed to mineral surfaces in bone, where they interfere with the action of the bone-resorbing osteoclasts. Bisphosphonates are internalized by osteoclasts and interfere with specific bioche …
Bisphosphonates inhibit bone resorption by being selectively taken up and adsorbed to mineral surfaces in bone, where they interfere with th …
Bisphosphonates Targeting Ion Channels and Musculoskeletal Effects.
Scala R, Maqoud F, Antonacci M, Dibenedetto JR, Perrone MG, Scilimati A, Castillo K, Latorre R, Conte D, Bendahhou S, Tricarico D. Scala R, et al. Front Pharmacol. 2022 Mar 15;13:837534. doi: 10.3389/fphar.2022.837534. eCollection 2022. Front Pharmacol. 2022. PMID: 35370739 Free PMC article. Review.
Bisphosphonates (BPs) are the most used bone-specific anti-resorptive agents, often chosen as first-line therapy in several bone diseases characterized by an imbalance between osteoblast-mediated bone production and osteoclast-mediated bone resorption. BPs target the fa …
Bisphosphonates (BPs) are the most used bone-specific anti-resorptive agents, often chosen as first-line therapy in several bone diseases ch …
How zoledronic acid improves osteoporosis by acting on osteoclasts.
Wang B, Zhan Y, Yan L, Hao D. Wang B, et al. Front Pharmacol. 2022 Aug 25;13:961941. doi: 10.3389/fphar.2022.961941. eCollection 2022. Front Pharmacol. 2022. PMID: 36091799 Free PMC article. Review.
Farnesyl pyrophosphate synthase (FPPS), reactive oxygen species (ROS), and ferroptosis that was first proposed in 2012, are all considered to be closely associated with zoledronic acid-induced osteoclast apoptosis. Here, we provide a brief review of th …
Farnesyl pyrophosphate synthase (FPPS), reactive oxygen species (ROS), and ferroptosis that was first proposed in 2012, …
Bisphosphonates: mode of action and pharmacology.
Russell RG. Russell RG. Pediatrics. 2007 Mar;119 Suppl 2:S150-62. doi: 10.1542/peds.2006-2023H. Pediatrics. 2007. PMID: 17332236 Review.
In contrast, the more potent, nitrogen-containing bisphosphonates (eg, pamidronate, alendronate, risedronate, ibandronate, and zoledronate) inhibit a key enzyme, farnesyl pyrophosphate synthase, in the mevalonate pathway, thereby preventing the biosynthesis o …
In contrast, the more potent, nitrogen-containing bisphosphonates (eg, pamidronate, alendronate, risedronate, ibandronate, and zoledronate) …
The Role of Geranylgeraniol in Managing Bisphosphonate-Related Osteonecrosis of the Jaw.
Chin KY, Ekeuku SO, Trias A. Chin KY, et al. Front Pharmacol. 2022 May 4;13:878556. doi: 10.3389/fphar.2022.878556. eCollection 2022. Front Pharmacol. 2022. PMID: 35600875 Free PMC article. Review.
Nitrogen-containing bisphosphonates suppress osteoclastic resorption by inhibiting farnesyl pyrophosphate synthase in the mevalonate pathway, leading to deficiency of the substrate for GTPase prenylation. ...In the current review, the in vitro effects …
Nitrogen-containing bisphosphonates suppress osteoclastic resorption by inhibiting farnesyl pyrophosphate synthase …
Role of bisphosphonates in osteoporosis caused by adult growth hormone deficiency.
Cheng Z, Li J, Chen Z, Ren W. Cheng Z, et al. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2024 Jun 28;49(6):839-847. doi: 10.11817/j.issn.1672-7347.2024.230469. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2024. PMID: 39311779 Free PMC article. Review.
Bisphosphonates inhibit bone resorption by targeting farnesyl pyrophosphate synthase in osteoclasts, and clinical trials have confirmed their efficacy in improving osteoporosis. ...
Bisphosphonates inhibit bone resorption by targeting farnesyl pyrophosphate synthase in osteoclasts, and clinica …
49 results