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Year Number of Results
2012 1
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2017 5
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2020 10
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71 results

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Page 1
Fasting-mimicking diet and hormone therapy induce breast cancer regression.
Caffa I, Spagnolo V, Vernieri C, Valdemarin F, Becherini P, Wei M, Brandhorst S, Zucal C, Driehuis E, Ferrando L, Piacente F, Tagliafico A, Cilli M, Mastracci L, Vellone VG, Piazza S, Cremonini AL, Gradaschi R, Mantero C, Passalacqua M, Ballestrero A, Zoppoli G, Cea M, Arrighi A, Odetti P, Monacelli F, Salvadori G, Cortellino S, Clevers H, De Braud F, Sukkar SG, Provenzani A, Longo VD, Nencioni A. Caffa I, et al. Nature. 2020 Jul;583(7817):620-624. doi: 10.1038/s41586-020-2502-7. Epub 2020 Jul 15. Nature. 2020. PMID: 32669709 Free PMC article.
Moreover, both fasting and a fasting-mimicking diet prevent tamoxifen-induced endometrial hyperplasia. ...These results support further clinical studies of a fasting-mimicking diet as an adjuvant to oestrogen therapy in hormone-rec …
Moreover, both fasting and a fasting-mimicking diet prevent tamoxifen-induced endometrial hyperplasia. ...These …
Cyclic fasting-mimicking diet in cancer treatment: Preclinical and clinical evidence.
Vernieri C, Ligorio F, Tripathy D, Longo VD. Vernieri C, et al. Cell Metab. 2024 Aug 6;36(8):1644-1667. doi: 10.1016/j.cmet.2024.06.014. Epub 2024 Jul 25. Cell Metab. 2024. PMID: 39059383 Free article. Review.
In preclinical tumor models, cyclic fasting and fasting-mimicking diets (FMDs) produce antitumor effects that become synergistic when combined with a wide range of standard anticancer treatments while protecting normal tissues from treatment-induced adverse e …
In preclinical tumor models, cyclic fasting and fasting-mimicking diets (FMDs) produce antitumor effects that become sy …
Fasting-Mimicking Diet Is Safe and Reshapes Metabolism and Antitumor Immunity in Patients with Cancer.
Vernieri C, Fucà G, Ligorio F, Huber V, Vingiani A, Iannelli F, Raimondi A, Rinchai D, Frigè G, Belfiore A, Lalli L, Chiodoni C, Cancila V, Zanardi F, Ajazi A, Cortellino S, Vallacchi V, Squarcina P, Cova A, Pesce S, Frati P, Mall R, Corsetto PA, Rizzo AM, Ferraris C, Folli S, Garassino MC, Capri G, Bianchi G, Colombo MP, Minucci S, Foiani M, Longo VD, Apolone G, Torri V, Pruneri G, Bedognetti D, Rivoltini L, de Braud F. Vernieri C, et al. Cancer Discov. 2022 Jan;12(1):90-107. doi: 10.1158/2159-8290.CD-21-0030. Epub 2021 Nov 17. Cancer Discov. 2022. PMID: 34789537 Free PMC article. Clinical Trial.
In tumor-bearing mice, cyclic fasting or fasting-mimicking diets (FMD) enhance the activity of antineoplastic treatments by modulating systemic metabolism and boosting antitumor immunity. ...In 101 patients, the FMD was safe, feasible, and resulted in a consi …
In tumor-bearing mice, cyclic fasting or fasting-mimicking diets (FMD) enhance the activity of antineoplastic treatment …
Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease.
Wei M, Brandhorst S, Shelehchi M, Mirzaei H, Cheng CW, Budniak J, Groshen S, Mack WJ, Guen E, Di Biase S, Cohen P, Morgan TE, Dorff T, Hong K, Michalsen A, Laviano A, Longo VD. Wei M, et al. Sci Transl Med. 2017 Feb 15;9(377):eaai8700. doi: 10.1126/scitranslmed.aai8700. Sci Transl Med. 2017. PMID: 28202779 Free PMC article. Clinical Trial.
We randomized 100 generally healthy participants from the United States into two study arms and tested the effects of a fasting-mimicking diet (FMD)-low in calories, sugars, and protein but high in unsaturated fats-on markers/risk factors associated with agin …
We randomized 100 generally healthy participants from the United States into two study arms and tested the effects of a fasting-mi …
Time-Restricted Eating, Intermittent Fasting, and Fasting-Mimicking Diets in Weight Loss.
Fanti M, Mishra A, Longo VD, Brandhorst S. Fanti M, et al. Curr Obes Rep. 2021 Jun;10(2):70-80. doi: 10.1007/s13679-021-00424-2. Epub 2021 Jan 29. Curr Obes Rep. 2021. PMID: 33512641 Review.
PURPOSE OF REVIEW: This article reviews the current literature on dietary interventions, including time-restricted eating (TRE), intermittent fasting (IF), and fasting-mimicking diets (FMD) and their effects on weight loss. RECENT FINDINGS: Dietary interventi …
PURPOSE OF REVIEW: This article reviews the current literature on dietary interventions, including time-restricted eating (TRE), intermitten …
Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape.
Salvadori G, Zanardi F, Iannelli F, Lobefaro R, Vernieri C, Longo VD. Salvadori G, et al. Cell Metab. 2021 Nov 2;33(11):2247-2259.e6. doi: 10.1016/j.cmet.2021.10.008. Cell Metab. 2021. PMID: 34731655 Free PMC article.
Metastatic tumors remain lethal due to primary/acquired resistance to therapy or cancer stem cell (CSC)-mediated repopulation. We show that a fasting-mimicking diet (FMD) activates starvation escape pathways in triple-negative breast cancer (TNBC) cells, whic …
Metastatic tumors remain lethal due to primary/acquired resistance to therapy or cancer stem cell (CSC)-mediated repopulation. We show that …
Fasting-Mimicking Diet Promotes Ngn3-Driven beta-Cell Regeneration to Reverse Diabetes.
Cheng CW, Villani V, Buono R, Wei M, Kumar S, Yilmaz OH, Cohen P, Sneddon JB, Perin L, Longo VD. Cheng CW, et al. Cell. 2017 Feb 23;168(5):775-788.e12. doi: 10.1016/j.cell.2017.01.040. Cell. 2017. PMID: 28235195 Free PMC article.
Stem-cell-based therapies can potentially reverse organ dysfunction and diseases, but the removal of impaired tissue and activation of a program leading to organ regeneration pose major challenges. In mice, a 4-day fasting mimicking diet (FMD) induces a stepw …
Stem-cell-based therapies can potentially reverse organ dysfunction and diseases, but the removal of impaired tissue and activation of a pro …
Fasting-mimicking diet causes hepatic and blood markers changes indicating reduced biological age and disease risk.
Brandhorst S, Levine ME, Wei M, Shelehchi M, Morgan TE, Nayak KS, Dorff T, Hong K, Crimmins EM, Cohen P, Longo VD. Brandhorst S, et al. Nat Commun. 2024 Feb 20;15(1):1309. doi: 10.1038/s41467-024-45260-9. Nat Commun. 2024. PMID: 38378685 Free PMC article. Clinical Trial.
In mice, periodic cycles of a fasting mimicking diet (FMD) protect normal cells while killing damaged cells including cancer and autoimmune cells, reduce inflammation, promote multi-system regeneration, and extend longevity. ...
In mice, periodic cycles of a fasting mimicking diet (FMD) protect normal cells while killing damaged cells including c …
Fasting-Mimicking Diet Modulates Microbiota and Promotes Intestinal Regeneration to Reduce Inflammatory Bowel Disease Pathology.
Rangan P, Choi I, Wei M, Navarrete G, Guen E, Brandhorst S, Enyati N, Pasia G, Maesincee D, Ocon V, Abdulridha M, Longo VD. Rangan P, et al. Cell Rep. 2019 Mar 5;26(10):2704-2719.e6. doi: 10.1016/j.celrep.2019.02.019. Cell Rep. 2019. PMID: 30840892 Free PMC article.
Dietary interventions are potentially effective therapies for inflammatory bowel diseases (IBDs). We tested the effect of 4-day fasting-mimicking diet (FMD) cycles on a chronic dextran sodium sulfate (DSS)-induced murine model resulting in symptoms and pathol …
Dietary interventions are potentially effective therapies for inflammatory bowel diseases (IBDs). We tested the effect of 4-day fasting …
Fasting and fasting mimicking diets in cancer prevention and therapy.
Blaževitš O, Di Tano M, Longo VD. Blaževitš O, et al. Trends Cancer. 2023 Mar;9(3):212-222. doi: 10.1016/j.trecan.2022.12.006. Epub 2023 Jan 14. Trends Cancer. 2023. PMID: 36646607 Review.
Fasting mimicking diets (FMDs) are emerging as effective dietary interventions with the potential to improve healthspan and decrease the incidence of cancer and other age-related diseases. Unlike chronic dietary restrictions or water-only fasting, FMDs repres …
Fasting mimicking diets (FMDs) are emerging as effective dietary interventions with the potential to improve healthspan and de …
71 results