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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1909 1
1925 1
1933 1
1942 1
1968 1
1969 1
1970 1
1971 1
1973 1
1974 1
1975 1
1976 1
1977 3
1978 4
1979 2
1980 2
1981 4
1982 3
1983 5
1984 2
1985 4
1986 11
1987 6
1988 6
1989 9
1990 9
1991 10
1992 16
1993 13
1994 7
1995 23
1996 19
1997 23
1998 19
1999 26
2000 29
2001 29
2002 19
2003 43
2004 38
2005 48
2006 43
2007 52
2008 68
2009 65
2010 82
2011 92
2012 72
2013 73
2014 78
2015 82
2016 84
2017 102
2018 109
2019 99
2020 123
2021 111
2022 113
2023 115
2024 119
2025 121
2026 19

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2,023 results

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Page 1
Beyond appetite regulation: Targeting energy expenditure, fat oxidation, and lean mass preservation for sustainable weight loss.
Christoffersen BØ, Sanchez-Delgado G, John LM, Ryan DH, Raun K, Ravussin E. Christoffersen BØ, et al. Obesity (Silver Spring). 2022 Apr;30(4):841-857. doi: 10.1002/oby.23374. Obesity (Silver Spring). 2022. PMID: 35333444 Free PMC article. Review.
New appetite-regulating antiobesity treatments such as semaglutide and agents under investigation such as tirzepatide show promise in achieving weight loss of 15% or more. Energy expenditure, fat oxidation, and lean mass preservation are important dete …
New appetite-regulating antiobesity treatments such as semaglutide and agents under investigation such as tirzepatide show promise in achiev …
GDF15 promotes weight loss by enhancing energy expenditure in muscle.
Wang D, Townsend LK, DesOrmeaux GJ, Frangos SM, Batchuluun B, Dumont L, Kuhre RE, Ahmadi E, Hu S, Rebalka IA, Gautam J, Jabile MJT, Pileggi CA, Rehal S, Desjardins EM, Tsakiridis EE, Lally JSV, Juracic ES, Tupling AR, Gerstein HC, Paré G, Tsakiridis T, Harper ME, Hawke TJ, Speakman JR, Blondin DP, Holloway GP, Jørgensen SB, Steinberg GR. Wang D, et al. Nature. 2023 Jul;619(7968):143-150. doi: 10.1038/s41586-023-06249-4. Epub 2023 Jun 28. Nature. 2023. PMID: 37380764 Free PMC article.
Caloric restriction that promotes weight loss is an effective strategy for treating non-alcoholic fatty liver disease and improving insulin sensitivity in people with type 2 diabetes(1). Despite its effectiveness, in most individuals, weight loss is us …
Caloric restriction that promotes weight loss is an effective strategy for treating non-alcoholic fatty liver disease and impr …
Tirzepatide did not impact metabolic adaptation in people with obesity, but increased fat oxidation.
Ravussin E, Sanchez-Delgado G, Martin CK, Beyl RA, Greenway FL, O'Farrell LS, Roell WC, Qian HR, Li J, Nishiyama H, Haupt A, Pratt EJ, Urva S, Milicevic Z, Coskun T. Ravussin E, et al. Cell Metab. 2025 May 6;37(5):1060-1074.e4. doi: 10.1016/j.cmet.2025.03.011. Epub 2025 Apr 8. Cell Metab. 2025. PMID: 40203836 Clinical Trial.
Tirzepatide, a glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist, promoted significant body weight reduction in the phase 3 clinical trials. We conducted a preclinical study and a phase 1 clinical trial (NCT04081337) to understand po …
Tirzepatide, a glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist, promoted significant body weigh …
Why is it so hard to lose fat? Because it has to get out through your nose! An exercise physiology laboratory on oxygen consumption, metabolism, and weight loss.
Merritt EK. Merritt EK. Adv Physiol Educ. 2021 Sep 1;45(3):599-606. doi: 10.1152/advan.00006.2021. Adv Physiol Educ. 2021. PMID: 34379483 Free article.
Exercise is thought to be an effective means to quick weight loss. However, few people have realistic exercise-induced weight loss expectations. Fewer understand how weight is "lost" and where the lost mass goes. Understanding that fat is …
Exercise is thought to be an effective means to quick weight loss. However, few people have realistic exercise-induced weig …
Unravelling cysteine-deficiency-associated rapid weight loss.
Varghese A, Gusarov I, Gamallo-Lana B, Dolgonos D, Mankan Y, Shamovsky I, Phan M, Jones R, Gomez-Jenkins M, White E, Wang R, Jones DR, Papagiannakopoulos T, Pacold ME, Mar AC, Littman DR, Nudler E. Varghese A, et al. Nature. 2025 Jul;643(8072):776-784. doi: 10.1038/s41586-025-08996-y. Epub 2025 May 21. Nature. 2025. PMID: 40399674 Free PMC article.
Here we investigated the impact of removing individual amino acids on the weight profiles of mice. We show that conditional cysteine restriction resulted in the most substantial weight loss when compared to essential amino acid restriction, amounting to 30% w …
Here we investigated the impact of removing individual amino acids on the weight profiles of mice. We show that conditional cysteine …
Obesity-induced tissue alterations resist weight loss: A mechanistic review.
Della Guardia L, Shin AC. Della Guardia L, et al. Diabetes Obes Metab. 2024 Aug;26(8):3045-3057. doi: 10.1111/dom.15637. Epub 2024 May 8. Diabetes Obes Metab. 2024. PMID: 38720199 Free article. Review.
Interventions aimed at weight control often have limited effectiveness in combating obesity. This review explores how obesity-induced dysfunction in white (WAT) and brown adipose tissue (BAT), skeletal muscle, and the brain blunt weight loss, leading to reten …
Interventions aimed at weight control often have limited effectiveness in combating obesity. This review explores how obesity-induced …
Efficacy and safety of prolonged water fasting: a narrative review of human trials.
Ezpeleta M, Cienfuegos S, Lin S, Pavlou V, Gabel K, Varady KA. Ezpeleta M, et al. Nutr Rev. 2024 Apr 12;82(5):664-675. doi: 10.1093/nutrit/nuad081. Nutr Rev. 2024. PMID: 37377031 Free PMC article. Review.
Results reveal that prolonged fasting for 5-20 days produces potent increases in circulating ketones, and mild to moderate weight loss of 2-10%. Approximately two-thirds of the weight lost is lean mass, and one-third is fat mass. ...It was shown that 3 …
Results reveal that prolonged fasting for 5-20 days produces potent increases in circulating ketones, and mild to moderate weight …
The GIP receptor activates futile calcium cycling in white adipose tissue to increase energy expenditure and drive weight loss in mice.
Yu X, Chen S, Funcke JB, Straub LG, Pirro V, Emont MP, Droz BA, Collins KA, Joung C, Pearson MJ, James CM, Babu GJ, Efthymiou V, Vernon A, Patti ME, An YA, Rosen ED, Coghlan MP, Samms RJ, Scherer PE, Kusminski CM. Yu X, et al. Cell Metab. 2025 Jan 7;37(1):187-204.e7. doi: 10.1016/j.cmet.2024.11.003. Epub 2024 Dec 5. Cell Metab. 2025. PMID: 39642881 Free PMC article.
We show that GIPR induction in the fat cell protects mice from diet-induced obesity and triggers profound weight loss (35%) in an obese setting. ...GIPR activation further triggers a metabolic memory effect, which maintains weight loss after the …
We show that GIPR induction in the fat cell protects mice from diet-induced obesity and triggers profound weight loss ( …
Insufficient sleep undermines dietary efforts to reduce adiposity.
Nedeltcheva AV, Kilkus JM, Imperial J, Schoeller DA, Penev PD. Nedeltcheva AV, et al. Ann Intern Med. 2010 Oct 5;153(7):435-41. doi: 10.7326/0003-4819-153-7-201010050-00006. Ann Intern Med. 2010. PMID: 20921542 Free PMC article. Clinical Trial.
RESULTS: Sleep curtailment decreased the proportion of weight lost as fat by 55% (1.4 vs. 0.6 kg with 8.5 vs. 5.5 hours of sleep opportunity, respectively; P = 0.043) and increased the loss of fat-free body mass by 60% (1.5 vs. 2.4 kg; P = 0.002). ...C …
RESULTS: Sleep curtailment decreased the proportion of weight lost as fat by 55% (1.4 vs. 0.6 kg with 8.5 vs. 5.5 hours of sle …
2,023 results