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Year Number of Results
2003 3
2004 1
2005 3
2006 2
2007 2
2009 1
2010 2
2011 3
2013 2
2014 1
2015 2
2016 1
2017 1
2020 0
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Page 1
Efficacy of Femarelle for the treatment of climacteric syndrome in postmenopausal women: An open label trial.
Chen FP, Chang CJ, Chao AS, Huang HY, Huang JP, Wu MH, Tsai CC, Kung FT, Chang CW, Tsai YC. Chen FP, et al. Taiwan J Obstet Gynecol. 2016 Jun;55(3):336-40. doi: 10.1016/j.tjog.2016.04.008. Taiwan J Obstet Gynecol. 2016. PMID: 27343311 Free article. Clinical Trial.
OBJECTIVE: To assess the effects of 2 months of treatment with Femarelle for climacteric syndrome in Taiwanese postmenopausal women. ...After 4 weeks and 8 weeks of treatment with Femarelle, patients showed statistically significant improvement in climacteric sympto …
OBJECTIVE: To assess the effects of 2 months of treatment with Femarelle for climacteric syndrome in Taiwanese postmenopausal women. …
Interaction between the effects of the selective estrogen modulator femarelle and a vitamin D analog in human umbilical artery vascular smooth muscle cells.
Somjen D, Knoll E, Sharon O, Many A, Stern N. Somjen D, et al. J Steroid Biochem Mol Biol. 2017 Nov;174:9-13. doi: 10.1016/j.jsbmb.2017.05.007. Epub 2017 May 20. J Steroid Biochem Mol Biol. 2017. PMID: 28536085
To further investigate the interaction between vitamin D system and estrogen-mimetic compounds in the human vasculature we studied the effect of the "less- calcemic" analog of 1,25(OH)(2)D(3) (1,25D); JK 1624F(2)-2 (JKF) in the presence of selective estrogen modulator femarell
To further investigate the interaction between vitamin D system and estrogen-mimetic compounds in the human vasculature we studied the effec …
The selective estrogen receptor modulator DT56a (Femarelle) does not affect platelet reactivity in normal or thrombophilic postmenopausal women.
Nachtigall MJ, Jessel RH, Flaumenhaft R, Nachtigall R, Yoles I, Naftolin F, Nachtigall LE. Nachtigall MJ, et al. Menopause. 2011 Mar;18(3):285-8. doi: 10.1097/gme.0b013e3181f2f01a. Menopause. 2011. PMID: 21037489
OBJECTIVE: The purpose of this study was to assess the effect of DT56a (Femarelle), a selective estrogen receptor modulator, on platelet function in normal and thrombophilic women being treated for severe menopausal symptoms. ...CONCLUSIONS: Femarelle, whose …
OBJECTIVE: The purpose of this study was to assess the effect of DT56a (Femarelle), a selective estrogen receptor modulator, o …
Efficacy and safety of standard versus low-dose Femarelle (DT56a) for the treatment of menopausal symptoms.
Yoles I, Yogev Y, Frenkel Y, Hirsch M, Nahum R, Kaplan B. Yoles I, et al. Clin Exp Obstet Gynecol. 2004;31(2):123-6. Clin Exp Obstet Gynecol. 2004. PMID: 15266766 Clinical Trial.
The aim of the current study was to examine the efficacy and safety of the two doses of Femarelle in the treatment of menopausal symptoms. MATERIALS AND METHODS: Eighty healthy postmenopausal women were randomly allocated to receive either the standard dose (SD) or low dos …
The aim of the current study was to examine the efficacy and safety of the two doses of Femarelle in the treatment of menopausal symp …
Brain-region responsiveness to DT56a (Femarelle) administration on allopregnanolone and opioid content in ovariectomized rats.
Pluchino N, Merlini S, Cubeddu A, Giannini A, Bucci F, Casarosa E, Cela V, Angioni S, Luisi M, Genazzani AR. Pluchino N, et al. Menopause. 2009 Sep-Oct;16(5):1037-43. doi: 10.1097/gme.0b013e31819b351e. Menopause. 2009. PMID: 19295450
OBJECTIVE: The natural selective estrogen receptor modulator DT56a (Femarelle), derived from soybean, has been shown to relieve menopausal vasomotor symptoms with no effect on sex steroid hormone levels or endometrial thickness.The purpose of the present study was t …
OBJECTIVE: The natural selective estrogen receptor modulator DT56a (Femarelle), derived from soybean, has been shown to reliev …
DT56a (Femarelle), contrary to estradiol-17β, is effective in human derived female osteoblasts in hyperglycemic condition.
Somjen D, Katzburg S, Sharon O, Hendel D, Yoles I. Somjen D, et al. J Steroid Biochem Mol Biol. 2011 Jan;123(1-2):25-9. doi: 10.1016/j.jsbmb.2010.10.001. Epub 2010 Oct 14. J Steroid Biochem Mol Biol. 2011. PMID: 20951203
We have reported previously, that female-derived cultured osteoblasts (hObs) responded to DT56a (Femarelle) measured by the stimulation of creatine kinase specific activity (CK), which is a marker for hormone responsiveness and (3)[H] thymidine incorporation into DN …
We have reported previously, that female-derived cultured osteoblasts (hObs) responded to DT56a (Femarelle) measured by the st …
Tofupill/Femarelle (DT56a): a new phyto-selective estrogen receptor modulator-like substance for the treatment of postmenopausal bone loss.
Yoles I, Yogev Y, Frenkel Y, Nahum R, Hirsch M, Kaplan B. Yoles I, et al. Menopause. 2003 Nov-Dec;10(6):522-5. doi: 10.1097/01.GME.0000064864.58809.77. Menopause. 2003. PMID: 14627860 Clinical Trial.
OBJECTIVE: To evaluate the efficacy of Tofupill/Femarelle (DT56a), a novel phyto-selective estrogen receptor modulator (SERM), in preserving bone mineral density (BMD) in postmenopausal women. DESIGN: The study sample consisted of 98 healthy, postmenopausal women wh …
OBJECTIVE: To evaluate the efficacy of Tofupill/Femarelle (DT56a), a novel phyto-selective estrogen receptor modulator (SERM), …
DT56a (Femarelle): a natural selective estrogen receptor modulator (SERM).
Somjen D, Katzburg S, Knoll E, Hendel D, Stern N, Kaye AM, Yoles I. Somjen D, et al. J Steroid Biochem Mol Biol. 2007 May;104(3-5):252-8. doi: 10.1016/j.jsbmb.2007.03.004. Epub 2007 Mar 14. J Steroid Biochem Mol Biol. 2007. PMID: 17428655
The natural compound DT56a (Femarelle) was shown to activate estrogen receptors in human cultured female derived osteoblasts. ...In human vascular cells, inhibition of DNA synthesis by E2 was completely abolished by DT56a and E2-induced CK was partially inhib …
The natural compound DT56a (Femarelle) was shown to activate estrogen receptors in human cultured female derived osteoblasts. …
DT56a (Tofupill/Femarelle) selectively stimulates creatine kinase specific activity in skeletal tissues of rats but not in the uterus.
Somjen D, Yoles I. Somjen D, et al. J Steroid Biochem Mol Biol. 2003 Jul;86(1):93-8. doi: 10.1016/s0960-0760(03)00252-8. J Steroid Biochem Mol Biol. 2003. PMID: 12943748
The novel natural product DT56a (Tofupill/Femarelle), derived from soybean, has been shown to relieve menopausal vasomotor symptoms and to increase bone mineral density with no effect on sex steroid hormone levels or endometrial thickness. ...Single short-term injec …
The novel natural product DT56a (Tofupill/Femarelle), derived from soybean, has been shown to relieve menopausal vasomotor sym …
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