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79 results

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Page 1
Oral Fenbendazole for Cancer Therapy in Humans and Animals.
Nguyen J, Nguyen TQ, Han BO, Hoang BX. Nguyen J, et al. Anticancer Res. 2024 Sep;44(9):3725-3735. doi: 10.21873/anticanres.17197. Anticancer Res. 2024. PMID: 39197912 Review.
Fenbendazole is a benzimidazole anthelmintic agent commonly used to treat animal parasitic infections. ...Despite this, insights can be drawn from existing in vitro and in vivo animal studies on its pharmacokinetics. Given the low cost of fenbendazole, its high safe …
Fenbendazole is a benzimidazole anthelmintic agent commonly used to treat animal parasitic infections. ...Despite this, insights can …
Synergistic intravesical instillation for bladder cancer: CRISPR-Cas13a and fenbendazole combination therapy.
Liang M, Wang Y, Liu L, Deng D, Yan Z, Feng L, Kong C, Li C, Li Y, Li G. Liang M, et al. J Exp Clin Cancer Res. 2024 Aug 12;43(1):223. doi: 10.1186/s13046-024-03146-0. J Exp Clin Cancer Res. 2024. PMID: 39128990 Free PMC article.
BACKGROUND: CRISPR-Cas13a is renowned for its precise and potent RNA editing capabilities in cancer therapy. While various material systems have demonstrated efficacy in supporting CRISPR-Cas13a to execute cellular functions in vitro efficiently and specifically, the devel …
BACKGROUND: CRISPR-Cas13a is renowned for its precise and potent RNA editing capabilities in cancer therapy. While various material s …
Fenbendazole and Diisopropylamine Dichloroacetate Exert Synergistic Anti-cancer Effects by Inducing Apoptosis and Arresting the Cell Cycle in A549 Lung Cancer Cells.
Nguyen TQ, Nguyen DH, Phan UTT, Tran PTT, LE HT, Nguyen SH, Nguyen J, Han BO, Hoang BX. Nguyen TQ, et al. Anticancer Res. 2024 Nov;44(11):4761-4772. doi: 10.21873/anticanres.17302. Anticancer Res. 2024. PMID: 39477286
BACKGROUND/AIM: Lung cancer is the leading cause of cancer-related mortality worldwide, accounting for approximately 2 million new cases and 1.8 million deaths annually. ...Despite advancements over the past 25 years, the prognosis of patients with lung cancer …
BACKGROUND/AIM: Lung cancer is the leading cause of cancer-related mortality worldwide, accounting for approximately 2 million …
Anticancer Evaluation of Methoxy Poly(Ethylene Glycol)-b-Poly(Caprolactone) Polymeric Micelles Encapsulating Fenbendazole and Rapamycin in Ovarian Cancer.
Shin YB, Choi JY, Shin DH, Lee JW. Shin YB, et al. Int J Nanomedicine. 2023 May 1;18:2209-2223. doi: 10.2147/IJN.S394712. eCollection 2023. Int J Nanomedicine. 2023. PMID: 37152471 Free PMC article.
Additionally, the average encapsulation efficiency of fenbendazole was 75.7 4.61% and that of rapamycin was 98.0 1.97%. In the clonogenic assay, M-FR was 6.9 times more effective than that free fenbendazole/rapamycin. ...The findings of our study lay a foundation fo …
Additionally, the average encapsulation efficiency of fenbendazole was 75.7 4.61% and that of rapamycin was 98.0 1.97%. In the clonog …
Transcriptome analysis reveals the anticancer effects of fenbendazole on ovarian cancer: an in vitro and in vivo study.
Wang X, Tian W, Wang N, Yang X, Liu Z, Li L, Zhao T, Wang C, Zhang H, Yang H, Jia Y. Wang X, et al. BMC Cancer. 2024 Dec 30;24(1):1593. doi: 10.1186/s12885-024-13361-9. BMC Cancer. 2024. PMID: 39736624 Free PMC article.
Here, we investigated the anticancer effects of fenbendazole (FBZ), a benzimidazole compound, on the regulation of apoptosis and mitotic catastrophe in A2780 and SKOV3 human epithelial ovarian cancer cells. ...Finally, oral administration of FBZ inhibited tumor grow …
Here, we investigated the anticancer effects of fenbendazole (FBZ), a benzimidazole compound, on the regulation of apoptosis and mito …
Fenbendazole as an Anticancer Agent? A Case Series of Self-Administration in Three Patients.
Makis W, Baghli I, Martinez P. Makis W, et al. Case Rep Oncol. 2025 May 26;18(1):856-863. doi: 10.1159/000546362. eCollection 2025 Jan-Dec. Case Rep Oncol. 2025. PMID: 40605964 Free PMC article.
BACKGROUND: Fenbendazole (FBZ), an inexpensive and widely accessible antiparasitic drug used in veterinary medicine, has garnered growing interest for its potential as an anticancer therapy. ...While FBZ has shown promise both in vitro and in vivo studies, clinical evidenc …
BACKGROUND: Fenbendazole (FBZ), an inexpensive and widely accessible antiparasitic drug used in veterinary medicine, has garnered gro …
Fenbendazole Exhibits Antitumor Activity Against Cervical Cancer Through Dual Targeting of Cancer Cells and Cancer Stem Cells: Evidence from In Vitro and In Vivo Models.
Lei X, Wang Y, Chen Y, Duan J, Gao X, Cong Z. Lei X, et al. Molecules. 2025 May 29;30(11):2377. doi: 10.3390/molecules30112377. Molecules. 2025. PMID: 40509264 Free PMC article.
Cervical cancer remains a major threat to women's health, with advanced cases often exhibiting recurrence and metastasis due to cancer stem cells driving therapy resistance. This study evaluated fenbendazole (FBZ), a repurposed veterinary anthelmintic, for it …
Cervical cancer remains a major threat to women's health, with advanced cases often exhibiting recurrence and metastasis due to ca …
Anti-cancer effect of fenbendazole-incorporated PLGA nanoparticles in ovarian cancer.
Chang CS, Ryu JY, Choi JK, Cho YJ, Choi JJ, Hwang JR, Choi JY, Noh JJ, Lee CM, Won JE, Han HD, Lee JW. Chang CS, et al. J Gynecol Oncol. 2023 Sep;34(5):e58. doi: 10.3802/jgo.2023.34.e58. Epub 2023 Apr 24. J Gynecol Oncol. 2023. PMID: 37170725 Free PMC article.
OBJECTIVE: Fenbendazole (FZ) has potential anti-cancer effects, but its poor water solubility limits its use for cancer therapy. In this study, we investigated the anti-cancer effect of FZ with different drug delivery methods on epithelial ovarian c …
OBJECTIVE: Fenbendazole (FZ) has potential anti-cancer effects, but its poor water solubility limits its use for cancer …
Synergistic anti-tumor effect of fenbendazole and diisopropylamine dichloroacetate in immunodeficient BALB/c nude mice transplanted with A549 lung cancer cells.
Nguyen TQ, Phan UTT, Can MV, Nguyen DH, Han B, Hoang BX. Nguyen TQ, et al. Transl Lung Cancer Res. 2025 Jul 31;14(7):2509-2521. doi: 10.21037/tlcr-2024-1272. Epub 2025 Jul 25. Transl Lung Cancer Res. 2025. PMID: 40799435 Free PMC article.
BACKGROUND: Lung cancer remains one of the leading causes of cancer-related deaths worldwide. Recent studies suggest that fenbendazole (FZ), even at micromolar doses, shows promising anticancer potential but can cause liver toxicity in some patients. ...CONCL …
BACKGROUND: Lung cancer remains one of the leading causes of cancer-related deaths worldwide. Recent studies suggest that f …
Anti-cancer effects of fenbendazole on 5-fluorouracil-resistant colorectal cancer cells.
Park D, Lee JH, Yoon SP. Park D, et al. Korean J Physiol Pharmacol. 2022 Sep 1;26(5):377-387. doi: 10.4196/kjpp.2022.26.5.377. Korean J Physiol Pharmacol. 2022. PMID: 36039738 Free PMC article.
Benzimidazole anthelmintic agents have been recently repurposed to overcome cancers resistant to conventional therapies. To evaluate the anti-cancer effects of benzimidazole on resistant cells, various cell death pathways were investigated in 5-fluorouracil-resistan …
Benzimidazole anthelmintic agents have been recently repurposed to overcome cancers resistant to conventional therapies. To evaluate …
79 results