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723 results

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Page 1
Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants.
Jomova K, Alomar SY, Alwasel SH, Nepovimova E, Kuca K, Valko M. Jomova K, et al. Arch Toxicol. 2024 May;98(5):1323-1367. doi: 10.1007/s00204-024-03696-4. Epub 2024 Mar 14. Arch Toxicol. 2024. PMID: 38483584 Free PMC article. Review.
An imbalance between ROS production and elimination is termed oxidative stress, a critical factor and common denominator of many chronic diseases such as cancer, cardiovascular diseases, metabolic diseases, neurological disorders (Alzheimer's and Parkinson's disease …
An imbalance between ROS production and elimination is termed oxidative stress, a critical factor and common denominator of ma …
Metals, toxicity and oxidative stress.
Valko M, Morris H, Cronin MT. Valko M, et al. Curr Med Chem. 2005;12(10):1161-208. doi: 10.2174/0929867053764635. Curr Med Chem. 2005. PMID: 15892631 Review.
Experimental results have also shown a link between vanadium and oxidative stress in the etiology of diabetes. The impact of zinc (Zn) on the immune system, the ability of zinc to act as an antioxidant in order to reduce oxidative stress and the neurop …
Experimental results have also shown a link between vanadium and oxidative stress in the etiology of diabetes. The impact of z …
Advances in metal-induced oxidative stress and human disease.
Jomova K, Valko M. Jomova K, et al. Toxicology. 2011 May 10;283(2-3):65-87. doi: 10.1016/j.tox.2011.03.001. Epub 2011 Mar 23. Toxicology. 2011. PMID: 21414382 Review.
A novel therapeutic approach to suppress oxidative stress is based on the development of dual function antioxidants comprising not only chelating, but also scavenging components. ...The aim of this review is to provide an overview of redox and non-redox metal-induce …
A novel therapeutic approach to suppress oxidative stress is based on the development of dual function antioxidants comprising …
A common mechanism of cellular death induced by bactericidal antibiotics.
Kohanski MA, Dwyer DJ, Hayete B, Lawrence CA, Collins JJ. Kohanski MA, et al. Cell. 2007 Sep 7;130(5):797-810. doi: 10.1016/j.cell.2007.06.049. Cell. 2007. PMID: 17803904 Free article.
We demonstrate that the mechanism of hydroxyl radical formation induced by bactericidal antibiotics is the end product of an oxidative damage cellular death pathway involving the tricarboxylic acid cycle, a transient depletion of NADH, destabilization of iron-sulfur …
We demonstrate that the mechanism of hydroxyl radical formation induced by bactericidal antibiotics is the end product of an oxidative …
Hypoxia aggravates ferroptosis in RPE cells by promoting the Fenton reaction.
Henning Y, Blind US, Larafa S, Matschke J, Fandrey J. Henning Y, et al. Cell Death Dis. 2022 Jul 29;13(7):662. doi: 10.1038/s41419-022-05121-z. Cell Death Dis. 2022. PMID: 35906211 Free PMC article.
We found that HIF stabilization aggravated oxidative stress-induced cell death by SI and iron-dependent ferroptosis was identified as the main cell death mechanism. ...Taken together, we show for the first time that HIF stabilization under oxidative …
We found that HIF stabilization aggravated oxidative stress-induced cell death by SI and iron-dependent ferroptosis was …
Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis.
Yoshida M, Minagawa S, Araya J, Sakamoto T, Hara H, Tsubouchi K, Hosaka Y, Ichikawa A, Saito N, Kadota T, Sato N, Kurita Y, Kobayashi K, Ito S, Utsumi H, Wakui H, Numata T, Kaneko Y, Mori S, Asano H, Yamashita M, Odaka M, Morikawa T, Nakayama K, Iwamoto T, Imai H, Kuwano K. Yoshida M, et al. Nat Commun. 2019 Jul 17;10(1):3145. doi: 10.1038/s41467-019-10991-7. Nat Commun. 2019. PMID: 31316058 Free PMC article.
Ferroptosis is a necrotic form of regulated cell death (RCD) mediated by phospholipid peroxidation in association with free iron-mediated Fenton reactions. Disrupted iron homeostasis resulting in excessive oxidative stress has been implic …
Ferroptosis is a necrotic form of regulated cell death (RCD) mediated by phospholipid peroxidation in association with free iron-medi …
Oxidative stress and neurodegeneration: the involvement of iron.
Carocci A, Catalano A, Sinicropi MS, Genchi G. Carocci A, et al. Biometals. 2018 Oct;31(5):715-735. doi: 10.1007/s10534-018-0126-2. Epub 2018 Jul 16. Biometals. 2018. PMID: 30014355 Review.
Many evidences indicate that oxidative stress plays a significant role in a variety of human disease states, including neurodegenerative diseases. ...Actually, free iron excess generates oxidative stress, particularly in brain, where anti-oxi …
Many evidences indicate that oxidative stress plays a significant role in a variety of human disease states, including neurode …
Effects of iron accumulation and its chelation on oxidative stress in intracortical implants.
Franklin ME, Grant JL, Lee GM, Alvarez-Ciara A, Bennett C, Mattis S, Gallardo N, Corrales N, Cui XT, Capadona JR, Streit WJ, Olivier JH, Keane RW, Dietrich WD, de Rivero Vaccari JP, Prasad A. Franklin ME, et al. Acta Biomater. 2025 Jun 15;200:703-723. doi: 10.1016/j.actbio.2025.05.026. Epub 2025 May 10. Acta Biomater. 2025. PMID: 40355018 Free PMC article.
Our results indicated significant elevation of NOX complex subunits across timepoints, suggesting sustained oxidative stress. In a separate group of animals, we administered an iron chelator, deferoxamine mesylate (DFX), to evaluate the effects of chelation o …
Our results indicated significant elevation of NOX complex subunits across timepoints, suggesting sustained oxidative stress. …
Iron-catalyzed oxidative stress compromises cancer promotional effect of BRCA2 haploinsufficiency through mitochondria-targeted ferroptosis.
Maeda Y, Motooka Y, Akatsuka S, Tanaka H, Mashimo T, Toyokuni S. Maeda Y, et al. Redox Biol. 2025 Sep;85:103739. doi: 10.1016/j.redox.2025.103739. Epub 2025 Jun 24. Redox Biol. 2025. PMID: 40609478 Free PMC article.
However, molecular sequences how BRCA2 insufficiency leads to carcinogenesis remains unelucidated. To assess whether Fenton reaction-based oxidative stress is a promotional risk factor of carcinogenesis in BRCA2 haploinsufficiency, we here applied i …
However, molecular sequences how BRCA2 insufficiency leads to carcinogenesis remains unelucidated. To assess whether Fenton reacti …
RNA Oxidative Damage by the Iron-Fenton Reaction is Influenced by Bicarbonate Concentration and Ligand Strength.
Dingman JC, Fleming AM, Burrows CJ. Dingman JC, et al. Chem Res Toxicol. 2025 Nov 17;38(11):2019-2025. doi: 10.1021/acs.chemrestox.5c00339. Epub 2025 Nov 4. Chem Res Toxicol. 2025. PMID: 41186277 Free PMC article.
Studies that monitor RNA damage by H(2)O(2) often omit the physiological buffer bicarbonate in the reaction, which fails to account for the influence of the buffer on the iron-Fenton reaction. ...The studies herein point toward the redirection of the …
Studies that monitor RNA damage by H(2)O(2) often omit the physiological buffer bicarbonate in the reaction, which fails to account f …
723 results