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Filters applied: . Clear all The following term was not found in PubMed: ferdele
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Did you mean fedele 2018 Neel MEK (1 results)?
SHP2 Inhibition Prevents Adaptive Resistance to MEK Inhibitors in Multiple Cancer Models.
Fedele C, Ran H, Diskin B, Wei W, Jen J, Geer MJ, Araki K, Ozerdem U, Simeone DM, Miller G, Neel BG, Tang KH. Fedele C, et al. Cancer Discov. 2018 Oct;8(10):1237-1249. doi: 10.1158/2159-8290.CD-18-0444. Epub 2018 Jul 25. Cancer Discov. 2018. PMID: 30045908 Free PMC article.
SHP099 inhibited activation of KRAS mutants with residual GTPase activity, impeded SOS/RAS/MEK/ERK1/2 reactivation in response to MEKi, and blocked ERK1/2-dependent transcriptional programs. ...We find that SHP2/MEK inhibitor combinations prevent adaptive resistance …
SHP099 inhibited activation of KRAS mutants with residual GTPase activity, impeded SOS/RAS/MEK/ERK1/2 reactivation in response to MEK …
SHP2 is required for BCR-ABL1-induced hematologic neoplasia.
Gu S, Sayad A, Chan G, Yang W, Lu Z, Virtanen C, Van Etten RA, Neel BG. Gu S, et al. Leukemia. 2018 Jan;32(1):203-213. doi: 10.1038/leu.2017.250. Epub 2017 Aug 14. Leukemia. 2018. PMID: 28804122 Free PMC article.
The mitogen-activated protein kinase kinase (MEK) / extracellular signal-regulated kinase (ERK) pathway is regulated by SHP2 in WT and BCR-ABL1(+) pre-B cells, but is only required for the proliferation of BCR-ABL1(+) cells. ...
The mitogen-activated protein kinase kinase (MEK) / extracellular signal-regulated kinase (ERK) pathway is regulated by SHP2 in WT an …
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