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Page 1
MMP Activity Detection in Zymograms.
Bencsik P, Bartekova M, Görbe A, Kiss K, Pálóczi J, Radosinska J, Szűcs G, Ferdinandy P. Bencsik P, et al. Among authors: ferdinandy p. Methods Mol Biol. 2017;1626:53-70. doi: 10.1007/978-1-4939-7111-4_6. Methods Mol Biol. 2017. PMID: 28608200
Matrix metalloproteinases (MMP) belong to a distinguished class of zinc-dependent endopeptidases. Zymography is a semi-quantitative tool for determining the activity of different MMP isoenzymes in a variety of biological samples. ...In situ zymography is a histologi …
Matrix metalloproteinases (MMP) belong to a distinguished class of zinc-dependent endopeptidases. Zymography is a semi-quantitative t …
Matrix Metalloproteinases Repress Hypertrophic Growth in Cardiac Myocytes.
Euler G, Locquet F, Kociszewska J, Osygus Y, Heger J, Schreckenberg R, Schlüter KD, Kenyeres É, Szabados T, Bencsik P, Ferdinandy P, Schulz R. Euler G, et al. Among authors: ferdinandy p. Cardiovasc Drugs Ther. 2021 Apr;35(2):353-365. doi: 10.1007/s10557-020-07138-y. Epub 2021 Jan 5. Cardiovasc Drugs Ther. 2021. PMID: 33400052 Free PMC article.
RESULTS: MMP-1, MMP-2, MMP-3, MMP-9 and MMP-14 mRNAs were detected in cardiomyocytes, and protein expression of MMP-2, MMP-9, and MMP-14 was identified. Hypertrophic stimulation of cardiomyocytes did not enhance, but interes …
RESULTS: MMP-1, MMP-2, MMP-3, MMP-9 and MMP-14 mRNAs were detected in cardiomyocytes, and protein express …
Serum lipids and cardiac function correlate with nitrotyrosine and MMP activity in coronary artery disease patients.
Bencsik P, Sasi V, Kiss K, Kupai K, Kolossváry M, Maurovich-Horvat P, Csont T, Ungi I, Merkely B, Ferdinandy P. Bencsik P, et al. Among authors: ferdinandy p. Eur J Clin Invest. 2015 Jul;45(7):692-701. doi: 10.1111/eci.12458. Epub 2015 Jun 1. Eur J Clin Invest. 2015. PMID: 25944577
Therefore, here we investigated the correlation between the markers of peroxynitrite-MMP signalling and hyperlipidaemia in patients with significant coronary stenosis. ...Studying the biomarkers of peroxynitrite-MMP pathway in large prospective trials …
Therefore, here we investigated the correlation between the markers of peroxynitrite-MMP signalling and hyperlipidaemia in pat …
Development of Matrix Metalloproteinase-2 Inhibitors for Cardioprotection.
Bencsik P, Kupai K, Görbe A, Kenyeres É, Varga ZV, Pálóczi J, Gáspár R, Kovács L, Weber L, Takács F, Hajdú I, Fabó G, Cseh S, Barna L, Csont T, Csonka C, Dormán G, Ferdinandy P. Bencsik P, et al. Among authors: ferdinandy p. Front Pharmacol. 2018 Apr 5;9:296. doi: 10.3389/fphar.2018.00296. eCollection 2018. Front Pharmacol. 2018. PMID: 29674965 Free PMC article.
We found that the MMP-inhibiting effects of imidazole and thiazole carboxylic acid-based compounds are superior in efficacy in comparison to the conventional hydroxamic acid derivatives of the same molecules. ...This is the first demonstration that imidazole …
We found that the MMP-inhibiting effects of imidazole and thiazole carboxylic acid-based compounds are superior in efficacy in …
Low-Dose Endotoxin Induces Late Preconditioning, Increases Peroxynitrite Formation, and Activates STAT3 in the Rat Heart.
Pipicz M, Kocsis GF, Sárváry-Arantes L, Bencsik P, Varga ZV, Ferdinandy P, Csont T. Pipicz M, et al. Among authors: ferdinandy p. Molecules. 2017 Mar 8;22(3):433. doi: 10.3390/molecules22030433. Molecules. 2017. PMID: 28282895 Free PMC article.
LPS pretreatment enhanced cardiac formation of the peroxynitrite marker 3-nitrotyrosine. LPS pretreatment also increased cardiac levels of the peroxynitrite precursor nitric oxide (NO) and superoxide. ...We conclude that LPS pretreatment enhances cardiac peroxyni …
LPS pretreatment enhanced cardiac formation of the peroxynitrite marker 3-nitrotyrosine. LPS pretreatment also increased cardiac leve …
Integrative characterization of chronic cigarette smoke-induced cardiopulmonary comorbidities in a mouse model.
Kemény Á, Csekő K, Szitter I, Varga ZV, Bencsik P, Kiss K, Halmosi R, Deres L, Erős K, Perkecz A, Kereskai L, László T, Kiss T, Ferdinandy P, Helyes Z. Kemény Á, et al. Among authors: ferdinandy p. Environ Pollut. 2017 Oct;229:746-759. doi: 10.1016/j.envpol.2017.04.098. Epub 2017 Jun 22. Environ Pollut. 2017. PMID: 28648837 Free article.
Leukocyte number in the bronchoalveolar lavage at month 2 and lung matrix metalloproteinases-2 and 9 (MMP-2/MMP-9) activities in months 5-6 significantly increased. Smoking triggered complex cytokine profile change in the lung with one characteristic inflammatory pe …
Leukocyte number in the bronchoalveolar lavage at month 2 and lung matrix metalloproteinases-2 and 9 (MMP-2/MMP-9) activities …
Cardioprotective Effect of Novel Matrix Metalloproteinase Inhibitors.
Gömöri K, Szabados T, Kenyeres É, Pipis J, Földesi I, Siska A, Dormán G, Ferdinandy P, Görbe A, Bencsik P. Gömöri K, et al. Among authors: ferdinandy p. Int J Mol Sci. 2020 Sep 23;21(19):6990. doi: 10.3390/ijms21196990. Int J Mol Sci. 2020. PMID: 32977437 Free PMC article.
BACKGROUND: We recently developed novel matrix metalloproteinase-2 (MMP-2) inhibitor small molecules for cardioprotection against ischemia/reperfusion injury and validated their efficacy in ischemia/reperfusion injury in cardiac myocytes. ...METHODS: Normocholesterolemic a …
BACKGROUND: We recently developed novel matrix metalloproteinase-2 (MMP-2) inhibitor small molecules for cardioprotection against isc …
Enhanced NO and superoxide generation in dysfunctional hearts from endotoxemic rats.
Khadour FH, Panas D, Ferdinandy P, Schulze C, Csont T, Lalu MM, Wildhirt SM, Schulz R. Khadour FH, et al. Among authors: ferdinandy p. Am J Physiol Heart Circ Physiol. 2002 Sep;283(3):H1108-15. doi: 10.1152/ajpheart.00549.2001. Am J Physiol Heart Circ Physiol. 2002. PMID: 12181141 Free article.
We studied the alterations in myocardial nitric oxide (NO), superoxide, and peroxynitrite generation along with cardiac mechanical function and efficiency in hearts from lipopolysaccharide (LPS)-treated rats. ...Enhanced generation of both NO and superoxide, and thus pe …
We studied the alterations in myocardial nitric oxide (NO), superoxide, and peroxynitrite generation along with cardiac mechanical fu …
Moderate inhibition of myocardial matrix metalloproteinase-2 by ilomastat is cardioprotective.
Bencsik P, Pálóczi J, Kocsis GF, Pipis J, Belecz I, Varga ZV, Csonka C, Görbe A, Csont T, Ferdinandy P. Bencsik P, et al. Among authors: ferdinandy p. Pharmacol Res. 2014 Feb;80:36-42. doi: 10.1016/j.phrs.2013.12.007. Epub 2013 Dec 28. Pharmacol Res. 2014. PMID: 24380772
Therefore, here we investigated if the MMP inhibitor ilomastat administered either before ischemia or before reperfusion is able to reduce infarct size via inhibition of MMP-2, the most abundant MMP in the rat heart. ...The cytoprotective concentration of ilo …
Therefore, here we investigated if the MMP inhibitor ilomastat administered either before ischemia or before reperfusion is able to r …
Preconditioning decreases ischemia/reperfusion-induced release and activation of matrix metalloproteinase-2.
Lalu MM, Csonka C, Giricz Z, Csont T, Schulz R, Ferdinandy P. Lalu MM, et al. Among authors: ferdinandy p. Biochem Biophys Res Commun. 2002 Aug 30;296(4):937-41. doi: 10.1016/s0006-291x(02)02019-3. Biochem Biophys Res Commun. 2002. PMID: 12200138
This was accompanied by a decrease in corresponding tissue MMP activities. Preconditioning significantly decreased the MMP-2 activity in the coronary effluent following test ischemia/reperfusion and preserved the MMP-2 protein content and activity in the myoc …
This was accompanied by a decrease in corresponding tissue MMP activities. Preconditioning significantly decreased the MMP-2 a …
38 results