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Page 1
Matrix Metalloproteinases Repress Hypertrophic Growth in Cardiac Myocytes.
Euler G, Locquet F, Kociszewska J, Osygus Y, Heger J, Schreckenberg R, Schlüter KD, Kenyeres É, Szabados T, Bencsik P, Ferdinandy P, Schulz R. Euler G, et al. Among authors: ferdinandy p. Cardiovasc Drugs Ther. 2021 Apr;35(2):353-365. doi: 10.1007/s10557-020-07138-y. Epub 2021 Jan 5. Cardiovasc Drugs Ther. 2021. PMID: 33400052 Free PMC article.
RESULTS: MMP-1, MMP-2, MMP-3, MMP-9 and MMP-14 mRNAs were detected in cardiomyocytes, and protein expression of MMP-2, MMP-9, and MMP-14 was identified. Hypertrophic stimulation of cardiomyocytes did not enhance, but interes …
RESULTS: MMP-1, MMP-2, MMP-3, MMP-9 and MMP-14 mRNAs were detected in cardiomyocytes, and protein express …
MMP Activity Detection in Zymograms.
Bencsik P, Bartekova M, Görbe A, Kiss K, Pálóczi J, Radosinska J, Szűcs G, Ferdinandy P. Bencsik P, et al. Among authors: ferdinandy p. Methods Mol Biol. 2017;1626:53-70. doi: 10.1007/978-1-4939-7111-4_6. Methods Mol Biol. 2017. PMID: 28608200
Matrix metalloproteinases (MMP) belong to a distinguished class of zinc-dependent endopeptidases. Zymography is a semi-quantitative tool for determining the activity of different MMP isoenzymes in a variety of biological samples. In substrate gel zymography, protein …
Matrix metalloproteinases (MMP) belong to a distinguished class of zinc-dependent endopeptidases. Zymography is a semi-quantitative t …
Development of Matrix Metalloproteinase-2 Inhibitors for Cardioprotection.
Bencsik P, Kupai K, Görbe A, Kenyeres É, Varga ZV, Pálóczi J, Gáspár R, Kovács L, Weber L, Takács F, Hajdú I, Fabó G, Cseh S, Barna L, Csont T, Csonka C, Dormán G, Ferdinandy P. Bencsik P, et al. Among authors: ferdinandy p. Front Pharmacol. 2018 Apr 5;9:296. doi: 10.3389/fphar.2018.00296. eCollection 2018. Front Pharmacol. 2018. PMID: 29674965 Free PMC article.
We found that the MMP-inhibiting effects of imidazole and thiazole carboxylic acid-based compounds are superior in efficacy in comparison to the conventional hydroxamic acid derivatives of the same molecules. ...This is the first demonstration that imidazole …
We found that the MMP-inhibiting effects of imidazole and thiazole carboxylic acid-based compounds are superior in efficacy in …
Cardioprotective Effect of Novel Matrix Metalloproteinase Inhibitors.
Gömöri K, Szabados T, Kenyeres É, Pipis J, Földesi I, Siska A, Dormán G, Ferdinandy P, Görbe A, Bencsik P. Gömöri K, et al. Among authors: ferdinandy p. Int J Mol Sci. 2020 Sep 23;21(19):6990. doi: 10.3390/ijms21196990. Int J Mol Sci. 2020. PMID: 32977437 Free PMC article.
BACKGROUND: We recently developed novel matrix metalloproteinase-2 (MMP-2) inhibitor small molecules for cardioprotection against ischemia/reperfusion injury and validated their efficacy in ischemia/reperfusion injury in cardiac myocytes. ...METHODS: Normocholesterolemic a …
BACKGROUND: We recently developed novel matrix metalloproteinase-2 (MMP-2) inhibitor small molecules for cardioprotection against isc …
Integrative characterization of chronic cigarette smoke-induced cardiopulmonary comorbidities in a mouse model.
Kemény Á, Csekő K, Szitter I, Varga ZV, Bencsik P, Kiss K, Halmosi R, Deres L, Erős K, Perkecz A, Kereskai L, László T, Kiss T, Ferdinandy P, Helyes Z. Kemény Á, et al. Among authors: ferdinandy p. Environ Pollut. 2017 Oct;229:746-759. doi: 10.1016/j.envpol.2017.04.098. Epub 2017 Jun 22. Environ Pollut. 2017. PMID: 28648837 Free article.
Leukocyte number in the bronchoalveolar lavage at month 2 and lung matrix metalloproteinases-2 and 9 (MMP-2/MMP-9) activities in months 5-6 significantly increased. Smoking triggered complex cytokine profile change in the lung with one characteristic inflammatory pe …
Leukocyte number in the bronchoalveolar lavage at month 2 and lung matrix metalloproteinases-2 and 9 (MMP-2/MMP-9) activities …
Serum lipids and cardiac function correlate with nitrotyrosine and MMP activity in coronary artery disease patients.
Bencsik P, Sasi V, Kiss K, Kupai K, Kolossváry M, Maurovich-Horvat P, Csont T, Ungi I, Merkely B, Ferdinandy P. Bencsik P, et al. Among authors: ferdinandy p. Eur J Clin Invest. 2015 Jul;45(7):692-701. doi: 10.1111/eci.12458. Epub 2015 Jun 1. Eur J Clin Invest. 2015. PMID: 25944577
Therefore, here we investigated the correlation between the markers of peroxynitrite-MMP signalling and hyperlipidaemia in patients with significant coronary stenosis. ...Studying the biomarkers of peroxynitrite-MMP pathway in large prospective trials …
Therefore, here we investigated the correlation between the markers of peroxynitrite-MMP signalling and hyperlipidaemia in pat …
Subantimicrobial Dose Doxycycline Worsens Chronic Arthritis-Induced Bone Microarchitectural Alterations in a Mouse Model: Role of Matrix Metalloproteinases?
Horváth Á, Botz B, Kiss T, Csekő K, Kiss I, Felinger A, Szabados T, Kenyeres É, Bencsik P, Mócsai A, Ferdinandy P, Helyes Z. Horváth Á, et al. Among authors: ferdinandy p. Front Pharmacol. 2019 Mar 20;10:233. doi: 10.3389/fphar.2019.00233. eCollection 2019. Front Pharmacol. 2019. PMID: 30949048 Free PMC article.
Therefore, we investigated the role of MMPs in the K/BxN serum-transfer model of RA with the broad-spectrum MMP inhibitor subantimicrobial dose doxycycline (SDD) using complex in vivo and in vitro methodolgy. ...This is the first demonstration that SDD worsens arthritis-in …
Therefore, we investigated the role of MMPs in the K/BxN serum-transfer model of RA with the broad-spectrum MMP inhibitor subantimicr …
The impact of age on cardiac function and extracellular matrix component expression in adverse post-infarction remodeling in mice.
Nagel F, Santer D, Stojkovic S, Kaun C, Schaefer AK, Krššák M, Abraham D, Bencsik P, Ferdinandy P, Kenyeres E, Szabados T, Wojta J, Trescher K, Kiss A, Podesser BK. Nagel F, et al. Among authors: ferdinandy p. Exp Gerontol. 2019 May;119:193-202. doi: 10.1016/j.exger.2019.02.008. Epub 2019 Feb 11. Exp Gerontol. 2019. PMID: 30763602

Age and MI were associated with impaired cardiac function accompanied by left-ventricular (LV) dilatation. mRNA expression of MMP-2 (7d: p < 0.05), TIMP-1 (7d: p < 0.05), TIMP-2 (7d: p < 0.05), Collagen-1 (3d and 7d: p < 0.05) and Collagen-3 (7d: p < 0.05) i

Age and MI were associated with impaired cardiac function accompanied by left-ventricular (LV) dilatation. mRNA expression of MMP-2 ( …
Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) Deletion but Not Inhibition of Extracellular PCSK9 Reduces Infarct Sizes Ex Vivo but Not In Vivo.
Schreckenberg R, Wolf A, Szabados T, Gömöri K, Szabó IA, Ágoston G, Brenner G, Bencsik P, Ferdinandy P, Schulz R, Schlüter KD. Schreckenberg R, et al. Among authors: ferdinandy p. Int J Mol Sci. 2022 Jun 10;23(12):6512. doi: 10.3390/ijms23126512. Int J Mol Sci. 2022. PMID: 35742954 Free PMC article.
A high-fat diet reduced the survival rate during ischemia and reperfusion, but in a PCSK9-independent manner that was associated with increased plasma matrix metalloproteinase (MMP)9 activity. PCSK9 deletion, but not the inhibition of extracellular PCSK9, reduces infarct s …
A high-fat diet reduced the survival rate during ischemia and reperfusion, but in a PCSK9-independent manner that was associated with increa …
Role of iNOS and peroxynitrite-matrix metalloproteinase-2 signaling in myocardial late preconditioning in rats.
Bencsik P, Kupai K, Giricz Z, Görbe A, Pipis J, Murlasits Z, Kocsis GF, Varga-Orvos Z, Puskás LG, Csonka C, Csont T, Ferdinandy P. Bencsik P, et al. Among authors: ferdinandy p. Am J Physiol Heart Circ Physiol. 2010 Aug;299(2):H512-8. doi: 10.1152/ajpheart.00052.2010. Epub 2010 Jun 11. Am J Physiol Heart Circ Physiol. 2010. PMID: 20543091 Free article.
We have previously shown that the inhibition of myocardial nitric oxide (NO) and peroxynitrite-matrix metalloproteinase (MMP) signaling by early preconditioning (PC) is involved in its cardioprotective effect. ...Late PC increased cardiac superoxide levels significa …
We have previously shown that the inhibition of myocardial nitric oxide (NO) and peroxynitrite-matrix metalloproteinase (MMP) …
37 results