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Page 1
Ferroptosis: mechanisms, biology and role in disease.
Jiang X, Stockwell BR, Conrad M. Jiang X, et al. Nat Rev Mol Cell Biol. 2021 Apr;22(4):266-282. doi: 10.1038/s41580-020-00324-8. Epub 2021 Jan 25. Nat Rev Mol Cell Biol. 2021. PMID: 33495651 Free PMC article. Review.
The research field of ferroptosis has seen exponential growth over the past few years, since the term was coined in 2012. ...Numerous organ injuries and degenerative pathologies are driven by ferroptosis. Intriguingly, therapy-resistant cancer cells, particularly th …
The research field of ferroptosis has seen exponential growth over the past few years, since the term was coined in 2012. ...Numerous …
Ferroptosis at the intersection of lipid metabolism and cellular signaling.
Liang D, Minikes AM, Jiang X. Liang D, et al. Mol Cell. 2022 Jun 16;82(12):2215-2227. doi: 10.1016/j.molcel.2022.03.022. Epub 2022 Apr 6. Mol Cell. 2022. PMID: 35390277 Free PMC article. Review.
Ferroptosis, a newly emerged form of regulated necrotic cell death, has been demonstrated to play an important role in multiple diseases including cancer, neurodegeneration, and ischemic organ injury. Mounting evidence also suggests its potential physiological function in …
Ferroptosis, a newly emerged form of regulated necrotic cell death, has been demonstrated to play an important role in multiple disea …
Ferroptosis Detection: From Approaches to Applications.
Zeng F, Nijiati S, Tang L, Ye J, Zhou Z, Chen X. Zeng F, et al. Angew Chem Int Ed Engl. 2023 Aug 28;62(35):e202300379. doi: 10.1002/anie.202300379. Epub 2023 Mar 23. Angew Chem Int Ed Engl. 2023. PMID: 36828775 Review.
Emerging approaches for the in situ detection of the major regulators and biological events across cellular, tissue, and in living subjects provide a multiscale perspective for studying ferroptosis. Furthermore, advanced applications that integrate ferroptosis detec …
Emerging approaches for the in situ detection of the major regulators and biological events across cellular, tissue, and in living subjects …
Ferroptosis: past, present and future.
Li J, Cao F, Yin HL, Huang ZJ, Lin ZT, Mao N, Sun B, Wang G. Li J, et al. Cell Death Dis. 2020 Feb 3;11(2):88. doi: 10.1038/s41419-020-2298-2. Cell Death Dis. 2020. PMID: 32015325 Free PMC article. Review.
Ferroptosis is a new type of cell death that was discovered in recent years and is usually accompanied by a large amount of iron accumulation and lipid peroxidation during the cell death process; the occurrence of ferroptosis is iron-dependent. ...How to intervene i …
Ferroptosis is a new type of cell death that was discovered in recent years and is usually accompanied by a large amount of iron accu …
Ferroptosis: molecular mechanisms and health implications.
Tang D, Chen X, Kang R, Kroemer G. Tang D, et al. Cell Res. 2021 Feb;31(2):107-125. doi: 10.1038/s41422-020-00441-1. Epub 2020 Dec 2. Cell Res. 2021. PMID: 33268902 Free PMC article. Review.
Cell death can be executed through different subroutines. Since the description of ferroptosis as an iron-dependent form of non-apoptotic cell death in 2012, there has been mounting interest in the process and function of ferroptosis. ...Here, we review current know …
Cell death can be executed through different subroutines. Since the description of ferroptosis as an iron-dependent form of non-apopt …
Signaling pathways and defense mechanisms of ferroptosis.
Liu J, Kang R, Tang D. Liu J, et al. FEBS J. 2022 Nov;289(22):7038-7050. doi: 10.1111/febs.16059. Epub 2021 Jun 17. FEBS J. 2022. PMID: 34092035 Free article. Review.
Selective activation of autophagic degradation pathways promotes ferroptosis by increasing iron accumulation to cause lipid peroxidation. In contrast, system xc(-) -glutathione-GPX4 axis plays a central role in limiting lipid peroxidation, although other antioxidants (such …
Selective activation of autophagic degradation pathways promotes ferroptosis by increasing iron accumulation to cause lipid peroxidat …
Broadening horizons: the role of ferroptosis in cancer.
Chen X, Kang R, Kroemer G, Tang D. Chen X, et al. Nat Rev Clin Oncol. 2021 May;18(5):280-296. doi: 10.1038/s41571-020-00462-0. Epub 2021 Jan 29. Nat Rev Clin Oncol. 2021. PMID: 33514910 Review.
The extent to which ferroptosis affects tumour biology is unclear, although several studies have found important correlations between mutations in cancer-relevant genes (for example, RAS and TP53), in genes encoding proteins involved in stress response pathways (such as NF …
The extent to which ferroptosis affects tumour biology is unclear, although several studies have found important correlations between …
Ferroptosis, a new form of cell death: opportunities and challenges in cancer.
Mou Y, Wang J, Wu J, He D, Zhang C, Duan C, Li B. Mou Y, et al. J Hematol Oncol. 2019 Mar 29;12(1):34. doi: 10.1186/s13045-019-0720-y. J Hematol Oncol. 2019. PMID: 30925886 Free PMC article. Review.
Aberrant ferroptosis in diverse cancer types and tissues were summarized, and we elaborated recent data about the novel actors of some "conventional" drugs or natural compounds as ferroptosis inducers in cancer. Finally, we deliberate future orientation for ferro …
Aberrant ferroptosis in diverse cancer types and tissues were summarized, and we elaborated recent data about the novel actors of som …
Ferroptosis as a novel therapeutic target for cardiovascular disease.
Wu X, Li Y, Zhang S, Zhou X. Wu X, et al. Theranostics. 2021 Jan 1;11(7):3052-3059. doi: 10.7150/thno.54113. eCollection 2021. Theranostics. 2021. PMID: 33537073 Free PMC article. Review.
The metabolism of iron, lipids, amino acids and glutathione tightly controls the initiation and execution of ferroptosis. Emerging evidence shows that ferroptosis is closely associated with the occurrence and progression of various diseases. ...This article reviews …
The metabolism of iron, lipids, amino acids and glutathione tightly controls the initiation and execution of ferroptosis. Emerging ev …
The emerging role of ferroptosis in inflammation.
Sun Y, Chen P, Zhai B, Zhang M, Xiang Y, Fang J, Xu S, Gao Y, Chen X, Sui X, Li G. Sun Y, et al. Biomed Pharmacother. 2020 Jul;127:110108. doi: 10.1016/j.biopha.2020.110108. Epub 2020 Mar 29. Biomed Pharmacother. 2020. PMID: 32234642 Free article. Review.
Ferroptosis is classified as regulated necrosis and is more immunogenic than apoptosis. To date, compelling evidence indicates that ferroptosis plays an important role in inflammation, and several antioxidants functioning as ferroptosis inhibitors have been s …
Ferroptosis is classified as regulated necrosis and is more immunogenic than apoptosis. To date, compelling evidence indicates that …
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