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Conservation of Archaeal C/D Box sRNA-Guided RNA Modifications.
Breuer R, Gomes-Filho JV, Randau L. Breuer R, et al. Front Microbiol. 2021 Mar 12;12:654029. doi: 10.3389/fmicb.2021.654029. eCollection 2021. Front Microbiol. 2021. PMID: 33776983 Free PMC article. Review.
Ribose 2'-O-methylations constitute the most abundant chemical rRNA modification and are, for example, involved in RNA folding and stabilization. In archaea, these modification sites are determined by variable sets of C/D box sRNAs that guide the activity of …
Ribose 2'-O-methylations constitute the most abundant chemical rRNA modification and are, for example, involved in RNA folding and stabiliza …
The multistructural forms of box C/D ribonucleoprotein particles.
Yu G, Zhao Y, Li H. Yu G, et al. RNA. 2018 Dec;24(12):1625-1633. doi: 10.1261/rna.068312.118. Epub 2018 Sep 25. RNA. 2018. PMID: 30254138 Free PMC article. Review.
Other box C/D RNPs continue to be uncovered with either unexpected or unknown functions. We summarize currently known box C/D RNP structures in this review and identify the Nop56/58 and box C/D RNA subunits as the key elements underlying …
Other box C/D RNPs continue to be uncovered with either unexpected or unknown functions. We summarize currently known box C …
Methylation guide RNAs without box C/D motifs.
Wang J, Yang Z, Ye K. Wang J, et al. RNA. 2022 Dec;28(12):1597-1605. doi: 10.1261/rna.079379.122. Epub 2022 Sep 20. RNA. 2022. PMID: 36127125 Free PMC article.
Box C/D RNAs guide site-specific 2'-O-methylation of RNAs in archaea and eukaryotes. ...Here, we engineered a new type of methylation guide that lacks C/D motifs and requires no L7Ae for assembly and function. We determined a crystal structure o …
Box C/D RNAs guide site-specific 2'-O-methylation of RNAs in archaea and eukaryotes. ...Here, we engineered a new type …
Archaeal fibrillarin-Nop5 heterodimer 2'-O-methylates RNA independently of the C/D guide RNP particle.
Tomkuvienė M, Ličytė J, Olendraitė I, Liutkevičiūtė Z, Clouet-d'Orval B, Klimašauskas S. Tomkuvienė M, et al. RNA. 2017 Sep;23(9):1329-1337. doi: 10.1261/rna.059832.116. Epub 2017 Jun 2. RNA. 2017. PMID: 28576826 Free PMC article.
Archaeal fibrillarin (aFib) is a well-characterized S-adenosyl methionine (SAM)-dependent RNA 2'-O-methyltransferase that is known to act in a large C/D ribonucleoprotein (RNP) complex together with Nop5 and L7Ae proteins and a box C/D guide RNA …
Archaeal fibrillarin (aFib) is a well-characterized S-adenosyl methionine (SAM)-dependent RNA 2'-O-methyltransferase that is known to …
The guide sRNA sequence determines the activity level of box C/D RNPs.
Graziadei A, Gabel F, Kirkpatrick J, Carlomagno T. Graziadei A, et al. Elife. 2020 Mar 23;9:e50027. doi: 10.7554/eLife.50027. Elife. 2020. PMID: 32202498 Free PMC article.
2'-O-rRNA methylation, which is essential in eukaryotes and archaea, is catalysed by the Box C/D RNP complex in an RNA-guided manner. ...Here, we provide the first structural evidence that, in the context of the Box C/D RNP, the affinity of the …
2'-O-rRNA methylation, which is essential in eukaryotes and archaea, is catalysed by the Box C/D RNP complex in an RNA- …
Structural organization of box C/D RNA-guided RNA methyltransferase.
Ye K, Jia R, Lin J, Ju M, Peng J, Xu A, Zhang L. Ye K, et al. Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13808-13. doi: 10.1073/pnas.0905128106. Epub 2009 Aug 5. Proc Natl Acad Sci U S A. 2009. PMID: 19666563 Free PMC article.
In archaea, a bipartite C/D RNA assembles with L7Ae, Nop5, and the methyltransferase fibrillarin into a modification enzyme with unique substrate specificity. ...We also built a model of a native C/D RNP with substrate and fibrillarin …
In archaea, a bipartite C/D RNA assembles with L7Ae, Nop5, and the methyltransferase fibrillarin into a modifica …
The Nop5-L7A-fibrillarin RNP complex and a novel box C/D containing sRNA of Halobacterium salinarum NRC-1.
Weisel J, Wagner S, Klug G. Weisel J, et al. Biochem Biophys Res Commun. 2010 Apr 9;394(3):542-7. doi: 10.1016/j.bbrc.2010.03.012. Epub 2010 Mar 4. Biochem Biophys Res Commun. 2010. PMID: 20206603
To analyze the putative box C/D RNP complex in the extremely halophilic Halobacterium salinarum NRC-1 we performed pull-down analysis and identified the proteins Nop5, L7A, and fibrillarin and the tRNA(Trp) intron, as a typical box C/D sRNA of t …
To analyze the putative box C/D RNP complex in the extremely halophilic Halobacterium salinarum NRC-1 we performed pull-down a …
Efficient RNA 2'-O-methylation requires juxtaposed and symmetrically assembled archaeal box C/D and C'/D' RNPs.
Tran EJ, Zhang X, Maxwell ES. Tran EJ, et al. EMBO J. 2003 Aug 1;22(15):3930-40. doi: 10.1093/emboj/cdg368. EMBO J. 2003. PMID: 12881427 Free PMC article.
In vitro assembly of an archaeal box C/D sRNP using recombinant core proteins L7, Nop56/58 and fibrillarin has yielded an RNA:protein enzyme that guides methylation from both the terminal box C/D core and internal C'/D' RNP complex …
In vitro assembly of an archaeal box C/D sRNP using recombinant core proteins L7, Nop56/58 and fibrillarin has yielded …
High-resolution structure of eukaryotic Fibrillarin interacting with Nop56 amino-terminal domain.
Höfler S, Lukat P, Blankenfeldt W, Carlomagno T. Höfler S, et al. RNA. 2021 Apr;27(4):496-512. doi: 10.1261/rna.077396.120. Epub 2021 Jan 22. RNA. 2021. PMID: 33483369 Free PMC article.
This simple chemical modification is thought to confer stability, promote RNA folding, and contribute to generate a heterogenous ribosome population with a yet-uncharacterized function. 2'-O-methylation occurs both in archaea and eukaryotes and is accomplished by the Box …
This simple chemical modification is thought to confer stability, promote RNA folding, and contribute to generate a heterogenous ribosome po …
Unusual features of fibrillarin cDNA and gene structure in Euglena gracilis: evolutionary conservation of core proteins and structural predictions for methylation-guide box C/D snoRNPs throughout the domain Eucarya.
Russell AG, Watanabe Y, Charette JM, Gray MW. Russell AG, et al. Nucleic Acids Res. 2005 May 13;33(9):2781-91. doi: 10.1093/nar/gki574. Print 2005. Nucleic Acids Res. 2005. PMID: 15894796 Free PMC article.
Box C/D ribonucleoprotein (RNP) particles mediate O2'-methylation of rRNA and other cellular RNA species. ...In protists, the primarily unicellular organisms comprising the bulk of eukaryotic diversity, the protein composition of box C/D RNPs has not y …
Box C/D ribonucleoprotein (RNP) particles mediate O2'-methylation of rRNA and other cellular RNA species. ...In protists, the …
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