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Palmitoylethanolamide and acetyl-L-carnitine act synergistically with duloxetine and pregabalin in fibromyalgia: results of a randomised controlled study.
Salaffi F, Farah S, Sarzi-Puttini P, Di Carlo M. Salaffi F, et al. Clin Exp Rheumatol. 2023 Jun;41(6):1323-1331. doi: 10.55563/clinexprheumatol/pmdzcq. Epub 2023 Jun 28. Clin Exp Rheumatol. 2023. PMID: 37378482 Free article. Clinical Trial.
OBJECTIVES: Fibromyalgia (FM) is characterised by a form of debilitating pain that is unresponsive to standard analgesics. The aim of this study was to evaluate the efficacy of supplementing ongoing pregabalin (PGB) and duloxetine (DLX) treatment with palmitoylethanolamide …
OBJECTIVES: Fibromyalgia (FM) is characterised by a form of debilitating pain that is unresponsive to standard analgesics. The aim of …
Acetyl-L-carnitine in chronic pain: A narrative review.
Sarzi-Puttini P, Giorgi V, Di Lascio S, Fornasari D. Sarzi-Puttini P, et al. Pharmacol Res. 2021 Nov;173:105874. doi: 10.1016/j.phrs.2021.105874. Epub 2021 Sep 7. Pharmacol Res. 2021. PMID: 34500063 Review.
Acetyl-L-carnitine (ALC) is an endogenous molecule that not only plays a role in energy metabolism, but also has antioxidant properties, protects from oxidative stress, modulates brain neurotransmitters such as acetylcholine, serotonin and dopamine, and acts …
Acetyl-L-carnitine (ALC) is an endogenous molecule that not only plays a role in energy metabolism, but also has antiox …
Acetyl-L-Carnitine as an Add-On Treatment in Fibromyalgia Syndrome: A Retrospective Analysis on 183 Patients, According to the Generalized Linear Mixed Model for Longitudinal Data.
Schweiger V, Villagrossi L, Taus F, Gottin L, Bonora E, Anderloni M, Varrassi G, Polati L, Nizzero M, Martini A, Polati E. Schweiger V, et al. Biomedicines. 2025 Mar 28;13(4):820. doi: 10.3390/biomedicines13040820. Biomedicines. 2025. PMID: 40299412 Free PMC article.
Background. Fibromyalgia Syndrome (FMS) is characterized by chronic widespread pain, sleep disturbances, fatigue and cognitive impairment. ...In this retrospective study, we analyzed data collected between 2017 and 2022 regarding Acetyl-L-Carnitine (AL …
Background. Fibromyalgia Syndrome (FMS) is characterized by chronic widespread pain, sleep disturbances, fatigue and cognitive impair …
Dietary Interventions in the Management of Fibromyalgia: A Systematic Review and Best-Evidence Synthesis.
Lowry E, Marley J, McVeigh JG, McSorley E, Allsopp P, Kerr D. Lowry E, et al. Nutrients. 2020 Aug 31;12(9):2664. doi: 10.3390/nu12092664. Nutrients. 2020. PMID: 32878326 Free PMC article.
Fibromyalgia syndrome (FMS) is characterised by chronic widespread pain alongside fatigue, poor sleep quality and numerous comorbidities. ...Supplementation with Chlorella green algae, coenzyme Q10, acetyl-l-carnitine or a combination of vitamin C and …
Fibromyalgia syndrome (FMS) is characterised by chronic widespread pain alongside fatigue, poor sleep quality and numerous comorbidit …
Neuronutritional Approach to Fibromyalgia Management: A Narrative Review.
Badaeva A, Danilov A, Kosareva A, Lepshina M, Novikov V, Vorobyeva Y, Danilov A. Badaeva A, et al. Pain Ther. 2024 Oct;13(5):1047-1061. doi: 10.1007/s40122-024-00641-2. Epub 2024 Jul 23. Pain Ther. 2024. PMID: 39042252 Free PMC article. Review.
Fibromyalgia (FM) is a complex and common syndrome characterized by chronic widespread pain, fatigue, sleep disturbances, and various functional symptoms without clear structural or pathological causes. ...Supplements such as vitamin D, magnesium, vitamin B12, coenzyme Q10 …
Fibromyalgia (FM) is a complex and common syndrome characterized by chronic widespread pain, fatigue, sleep disturbances, and various …
A review of current evidence for acetyl-l-carnitine in the treatment of depression.
Wang SM, Han C, Lee SJ, Patkar AA, Masand PS, Pae CU. Wang SM, et al. J Psychiatr Res. 2014 Jun;53:30-7. doi: 10.1016/j.jpsychires.2014.02.005. Epub 2014 Feb 15. J Psychiatr Res. 2014. PMID: 24607292 Review.
Despite numerous antidepressants available, many patients with depression do not achieve adequate response rendering needs for novel antidepressants with different mechanism of actions. Acetyl-l-carnitine (ALC) is a potential antidepressant with novel mechani …
Despite numerous antidepressants available, many patients with depression do not achieve adequate response rendering needs for novel antidep …
Nutritional Interventions in the Management of Fibromyalgia Syndrome.
Pagliai G, Giangrandi I, Dinu M, Sofi F, Colombini B. Pagliai G, et al. Nutrients. 2020 Aug 20;12(9):2525. doi: 10.3390/nu12092525. Nutrients. 2020. PMID: 32825400 Free PMC article.
Fibromyalgia (FM) is a multifactorial syndrome of unknown etiology, characterized by widespread chronic pain and various somatic and psychological manifestations. ...
Fibromyalgia (FM) is a multifactorial syndrome of unknown etiology, characterized by widespread chronic pain and various somatic and …
Double-blind, multicenter trial comparing acetyl l-carnitine with placebo in the treatment of fibromyalgia patients.
Rossini M, Di Munno O, Valentini G, Bianchi G, Biasi G, Cacace E, Malesci D, La Montagna G, Viapiana O, Adami S. Rossini M, et al. Clin Exp Rheumatol. 2007 Mar-Apr;25(2):182-8. Clin Exp Rheumatol. 2007. PMID: 17543140 Clinical Trial.
OBJECTIVE: Fibromyalgia (FMS) is a chronic syndrome characterized by widespread pain, troubled sleep, disturbed mood, and fatigue. ...In this multicenter randomized clinical trial we evaluated the efficacy of acetyl L-carnitine (LAC) in patients with o …
OBJECTIVE: Fibromyalgia (FMS) is a chronic syndrome characterized by widespread pain, troubled sleep, disturbed mood, and fatigue. .. …
What's in the literature?
Lacomis D, El-Dokla A. Lacomis D, et al. J Clin Neuromuscul Dis. 2013 Sep;15(1):34-42. doi: 10.1097/CND.0b013e3182a3b21c. J Clin Neuromuscul Dis. 2013. PMID: 23965408 Review.
In amyotrophic lateral sclerosis (ALS), a recent double-blind placebo-controlled trial of acetyl-L-carnitine along with riluzole showed probable benefit in 42 patients compared with 40 patients who received placebo. ...Finally, the spectrum of small fiber neu …
In amyotrophic lateral sclerosis (ALS), a recent double-blind placebo-controlled trial of acetyl-L-carnitine along with …
A randomised controlled trial comparing duloxetine and acetyl L-carnitine in fibromyalgic patients: preliminary data.
Leombruni P, Miniotti M, Colonna F, Sica C, Castelli L, Bruzzone M, Parisi S, Fusaro E, Sarzi-Puttini P, Atzeni F, Torta RG. Leombruni P, et al. Clin Exp Rheumatol. 2015 Jan-Feb;33(1 Suppl 88):S82-5. Epub 2015 Mar 18. Clin Exp Rheumatol. 2015. PMID: 25786048 Clinical Trial.
The aim of this randomised controlled trial was to compare the effects of duloxetine and acetyl L-carnitine on pain, depression, anxiety and well-being in FMS patients. METHODS: Sixty-five female outpatients with FMS diagnosed by a rheumatologist were recruit …
The aim of this randomised controlled trial was to compare the effects of duloxetine and acetyl L-carnitine on pain, de …
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