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26 results

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Page 1
EULAR revised recommendations for the management of fibromyalgia.
Macfarlane GJ, Kronisch C, Dean LE, Atzeni F, Häuser W, Fluß E, Choy E, Kosek E, Amris K, Branco J, Dincer F, Leino-Arjas P, Longley K, McCarthy GM, Makri S, Perrot S, Sarzi-Puttini P, Taylor A, Jones GT. Macfarlane GJ, et al. Ann Rheum Dis. 2017 Feb;76(2):318-328. doi: 10.1136/annrheumdis-2016-209724. Epub 2016 Jul 4. Ann Rheum Dis. 2017. PMID: 27377815 Free article. Review.
OBJECTIVE: The original European League Against Rheumatism recommendations for managing fibromyalgia assessed evidence up to 2005. The paucity of studies meant that most recommendations were 'expert opinion'. METHODS: A multidisciplinary group from 12 countries assessed ev …
OBJECTIVE: The original European League Against Rheumatism recommendations for managing fibromyalgia assessed evidence up to 2005. Th …
Pain relief by targeting nonrestorative sleep in fibromyalgia: a phase 3 randomized trial of bedtime sublingual cyclobenzaprine.
Lederman S, Arnold LM, Vaughn B, Engels JM, Kelley M, Sullivan GM. Lederman S, et al. Pain Med. 2026 Jan 1;27(1):86-94. doi: 10.1093/pm/pnaf089. Pain Med. 2026. PMID: 40627411 Free PMC article. Clinical Trial.
OBJECTIVE: Fibromyalgia is the prototypic nociplastic chronic pain syndrome, characterized by widespread pain, nonrestorative sleep, and fatigue. ...Bedtime TNX-102 SL (sublingual cyclobenzaprine) 5.6 mg was associated with significant improvements versus pla …
OBJECTIVE: Fibromyalgia is the prototypic nociplastic chronic pain syndrome, characterized by widespread pain, nonrestorative slee …
Efficacy and Safety of Sublingual Cyclobenzaprine for the Treatment of Fibromyalgia: Results From a Randomized, Double-Blind, Placebo-Controlled Trial.
Lederman S, Arnold LM, Vaughn B, Kelley M, Sullivan GM. Lederman S, et al. Arthritis Care Res (Hoboken). 2023 Nov;75(11):2359-2368. doi: 10.1002/acr.25142. Epub 2023 Jul 4. Arthritis Care Res (Hoboken). 2023. PMID: 37165930 Clinical Trial.
OBJECTIVE: To evaluate the efficacy and safety of TNX-102 SL, a once-nightly sublingual formulation of cyclobenzaprine, in reducing pain in patients with fibromyalgia (FM). METHODS: RELIEF was a double-blind, randomized, placebo-controlled trial. ...Secondary end po …
OBJECTIVE: To evaluate the efficacy and safety of TNX-102 SL, a once-nightly sublingual formulation of cyclobenzaprine, in reducing p …
The effects of cyclobenzaprine on sleep physiology and symptoms in patients with fibromyalgia.
Reynolds WJ, Moldofsky H, Saskin P, Lue FA. Reynolds WJ, et al. J Rheumatol. 1991 Mar;18(3):452-4. J Rheumatol. 1991. PMID: 1856814 Clinical Trial.
A double blind, placebo controlled, crossover design study examined overnight sleep physiology, pain, fatigue, and mood symptoms in 12 patients with fibromyalgia treated with cyclobenzaprine. ...Pain, including tender point count and dolorimetry, mood ratings …
A double blind, placebo controlled, crossover design study examined overnight sleep physiology, pain, fatigue, and mood symptoms in 1 …
Treatment of fibromyalgia with cyclobenzaprine: A meta-analysis.
Tofferi JK, Jackson JL, O'Malley PG. Tofferi JK, et al. Arthritis Rheum. 2004 Feb 15;51(1):9-13. doi: 10.1002/art.20076. Arthritis Rheum. 2004. PMID: 14872449
OBJECTIVE: To systematically review the effectiveness of cyclobenzaprine in the treatment of fibromyalgia. METHODS: Articles describing randomized, placebo-controlled trials of cyclobenzaprine in people with fibromyalgia were obtained from Medline, EMB …
OBJECTIVE: To systematically review the effectiveness of cyclobenzaprine in the treatment of fibromyalgia. METHODS: Articles d …
Management of sleep disorders in fibromyalgia.
Moldofsky H. Moldofsky H. Rheum Dis Clin North Am. 2002 May;28(2):353-65. doi: 10.1016/s0889-857x(01)00012-6. Rheum Dis Clin North Am. 2002. PMID: 12122923 Review.
Traditional hypnotic agents, while helpful in initiating and maintaining sleep and reducing daytime tiredness, do not provide restorative sleep or reduce pain. Tricyclic drugs, such as amitriptyline and cyclobenzaprine, may provide long term benefit fo …
Traditional hypnotic agents, while helpful in initiating and maintaining sleep and reducing daytime tiredness, do not provide restora …
Effects of bedtime very low dose cyclobenzaprine on symptoms and sleep physiology in patients with fibromyalgia syndrome: a double-blind randomized placebo-controlled study.
Moldofsky H, Harris HW, Archambault WT, Kwong T, Lederman S. Moldofsky H, et al. J Rheumatol. 2011 Dec;38(12):2653-63. doi: 10.3899/jrheum.110194. Epub 2011 Sep 1. J Rheumatol. 2011. PMID: 21885490 Free article. Clinical Trial.
OBJECTIVE: To determine the effects of bedtime very low dose (VLD) cyclobenzaprine (CBP) on symptoms and sleep physiology of patients with fibromyalgia (FM), unrefreshing sleep, and the alpha-nonREM sleep electroencephalographic (EEG) anomaly at …
OBJECTIVE: To determine the effects of bedtime very low dose (VLD) cyclobenzaprine (CBP) on symptoms and sleep physiology of p …
Myalgias and Myopathies: Fibromyalgia.
McCarthy J. McCarthy J. FP Essent. 2016 Jan;440:11-5. FP Essent. 2016. PMID: 26734831 Review.
Fibromyalgia is a syndrome of chronic widespread pain typically accompanied by fatigue, nonrestorative sleep, cognitive dysfunction, and mood disorders. ...Strong evidence of benefit exists for tricyclic antidepressants, cyclobenzaprine, and serotonin-norepin …
Fibromyalgia is a syndrome of chronic widespread pain typically accompanied by fatigue, nonrestorative sleep, cognitive dysfun …
A randomized trial of cyclobenzaprine for the treatment of fibromyalgia.
Quimby LG, Gratwick GM, Whitney CD, Block SR. Quimby LG, et al. J Rheumatol Suppl. 1989 Nov;19:140-3. J Rheumatol Suppl. 1989. PMID: 2481741 Clinical Trial.
We attempted a randomized, double blind trial of placebo vs cyclobenzaprine (Flexeril) in 40 female patients with fibromyalgia from a private rheumatology practice in Maine. Patient reports and physician global assessments indicated that cyclobenzaprine was m …
We attempted a randomized, double blind trial of placebo vs cyclobenzaprine (Flexeril) in 40 female patients with fibromyalgia …
26 results