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Year Number of Results
1993 5
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47 results

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Page 1
Topical non-steroidal anti-inflammatory drug use for pediatric acute musculoskeletal pain: a scoping review.
Alaimo DF, Al Masri M, Eltorki M. Alaimo DF, et al. CJEM. 2026 Feb;28(2):119-128. doi: 10.1007/s43678-025-00982-7. Epub 2025 Sep 15. CJEM. 2026. PMID: 40952589
Interventions included ketoprofen gel, methyl salicylate/1-menthol patch, and diclofenac epolamine patch for ankle sprains or minor soft tissue injuries. Treatment durations ranged from 30 minutes to 14 days. Studies varied in design, intervention protocols, outcome …
Interventions included ketoprofen gel, methyl salicylate/1-menthol patch, and diclofenac epolamine patch for ankle sprains or …
Treatment Satisfaction, Efficacy, and Tolerability of Low-Dose Diclofenac Epolamine Soft Capsules in Acute, Mild, or Moderate Musculoskeletal Pain: A Prospective Open-Label, Single-Arm Interventional Study.
Trevisan CLM, Carraro A, Baldari GLA; Study 18I-Fsg08 Investigators. Trevisan CLM, et al. Pain Ther. 2023 Oct;12(5):1149-1163. doi: 10.1007/s40122-023-00531-z. Epub 2023 Jun 14. Pain Ther. 2023. PMID: 37314686 Free PMC article.
This study evaluated treatment satisfaction, effectiveness, and tolerability of a low-dose diclofenac epolamine 12.5-mg soft capsule formulation (DHEP 12.5-mg capsules) using patient-reported outcome measures in a real-life setting over a short period (3 days) in su …
This study evaluated treatment satisfaction, effectiveness, and tolerability of a low-dose diclofenac epolamine 12.5-mg soft c …
Efficacy and safety of Diclofenac sodium plaster in patients with acute pain of the limbs: a randomized, placebo and active-controlled, double-blind, parallel-group trial.
Pabst H, Gruber G, Picciotto R, Barbaro B, Giordan N. Pabst H, et al. Eur Rev Med Pharmacol Sci. 2023 Apr;27(7):3181-3190. doi: 10.26355/eurrev_202304_31952. Eur Rev Med Pharmacol Sci. 2023. PMID: 37070921 Free article. Clinical Trial.
OBJECTIVE: The aim of the present study was to assess the safety and efficacy of Diclofenac sodium (DS) 140 mg medicated plaster vs. Diclofenac epolamine (DIEP) 180 mg medicated plaster and placebo plaster, for the treatment of painful disease due to traumati …
OBJECTIVE: The aim of the present study was to assess the safety and efficacy of Diclofenac sodium (DS) 140 mg medicated plaster vs. …
Effect of microneedles shape on skin penetration and transdermal drug administration.
De Martino S, Battisti M, Napolitano F, Palladino A, Serpico L, Amendola E, Martone A, De Girolamo P, Squillace A, Dardano P, De Stefano L, Dello Iacono S. De Martino S, et al. Biomater Adv. 2022 Nov;142:213169. doi: 10.1016/j.bioadv.2022.213169. Epub 2022 Oct 22. Biomater Adv. 2022. PMID: 36302329
Microneedle (MN) patches are highly efficient and versatile tools for transdermal drug administration, in particular for pain-free, self-medication and rapid local applications. Diffraction ultraviolet (UV) light lithography offers an advanced method in fabricating poly(et …
Microneedle (MN) patches are highly efficient and versatile tools for transdermal drug administration, in particular for pain-free, s …
Safety and Efficacy of the FLECTOR (Diclofenac Epolamine) Topical System in Children with Minor Soft Tissue Injuries: A Phase IV Non-randomized Clinical Trial.
Jones CA, Hoehler FK, Frangione V, Ledesma G, Wisman PP Jr, Jones C. Jones CA, et al. Clin Drug Investig. 2022 Jan;42(1):43-51. doi: 10.1007/s40261-021-01101-x. Epub 2021 Nov 26. Clin Drug Investig. 2022. PMID: 34826122 Free PMC article. Clinical Trial.
BACKGROUND AND OBJECTIVE: A topical formulation of diclofenac (FLECTOR diclofenac epolamine topical system (FDETS)) is approved in adults for the treatment of acute pain due to minor strains, sprains, and contusions; however, its safety and effi …
BACKGROUND AND OBJECTIVE: A topical formulation of diclofenac (FLECTOR diclofenac epolamine topical system (FDET …
Rationale and evidence for the incorporation of heparin into the diclofenac epolamine medicated plaster.
Rainsford KD, Roberts MS, Nencioni A, Jones C. Rainsford KD, et al. Curr Med Res Opin. 2019 Jun;35(6):989-1002. doi: 10.1080/03007995.2018.1551194. Epub 2018 Dec 20. Curr Med Res Opin. 2019. PMID: 30474433 Review.
OBJECTIVE: The nonsteroidal anti-inflammatory drug (NSAID) diclofenac epolamine (DHEP) formulated as a topical patch has demonstrated efficacy and safety in the localized treatment of acute pain from minor strains, sprains and contusions, and for epicondyliti …
OBJECTIVE: The nonsteroidal anti-inflammatory drug (NSAID) diclofenac epolamine (DHEP) formulated as a topical patch has demon …
Diclofenac epolamine topical patch for the treatment of pain.
Affaitati G, Giamberardino MA, Lapenna D, Costantini R. Affaitati G, et al. J Biol Regul Homeost Agents. 2018 May-Jun;32(3):435-441. J Biol Regul Homeost Agents. 2018. PMID: 29921367
This review evaluates the effectiveness and safety of a topical diclofenac preparation, diclofenac epolamine (DHEP) patch 1.3% or diclofenac epolamine patch with heparin as excipient (DHEP+H) in treating mild-to-moderate pain. DHEP patch …
This review evaluates the effectiveness and safety of a topical diclofenac preparation, diclofenac epolamine (DHEP) pat …
Effects of topical diclofenac plus heparin (DHEP+H plaster) on somatic pain sensitivity in healthy subjects with a latent algogenic condition of the lower limb.
Affaitati G, Fabrizio A, Frangione V, Lanzarotti A, Lopopolo M, Tafuri E, Lapenna D, Giamberardino MA, Costantini R. Affaitati G, et al. Pain Pract. 2015 Jan;15(1):58-67. doi: 10.1111/papr.12161. Epub 2014 Jan 17. Pain Pract. 2015. PMID: 24433223 Clinical Trial.
OBJECTIVE: To evaluate whether a diclofenac epolamine + heparin topical (plaster) is more effective than diclofenac plaster alone in reducing deep somatic hyperalgesia in subjects without spontaneous pain and whether the effect is linked to or independ …
OBJECTIVE: To evaluate whether a diclofenac epolamine + heparin topical (plaster) is more effective than diclofenac pla …
Topical NSAID formulations.
McPherson ML, Cimino NM. McPherson ML, et al. Pain Med. 2013 Dec;14 Suppl 1:S35-9. doi: 10.1111/pme.12288. Pain Med. 2013. PMID: 24373109 Review.
RESULTS: In the United States, several topical NSAID products are approved to treat painful conditions including diclofenac sodium 1% gel (Voltaren Gel ; Endo Pharmaceuticals), diclofenac sodium topical solution 1.5% w/w in 45.5% dimethyl sulfoxide (PENNSAID ; Malli …
RESULTS: In the United States, several topical NSAID products are approved to treat painful conditions including diclofenac sodium 1% …
Diclofenac epolamine medicated plaster in the treatment of minor soft tissue injuries: a multicenter randomized controlled trial.
Li C, Frangione V, Rovati S, Zheng Q. Li C, et al. Curr Med Res Opin. 2013 Sep;29(9):1137-46. doi: 10.1185/03007995.2013.816669. Epub 2013 Jul 3. Curr Med Res Opin. 2013. PMID: 23777324 Clinical Trial.
OBJECTIVE: To investigate the efficacy and safety of a topical plaster containing diclofenac epolamine (DHEP) 1.3% in the treatment of patients with acute minor soft tissue injuries in China. ...MAIN OUTCOME MEASURES: The primary efficacy endpoint was the mean chang …
OBJECTIVE: To investigate the efficacy and safety of a topical plaster containing diclofenac epolamine (DHEP) 1.3% in the trea …
47 results