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Page 1
Comparison of wild-type and high-risk PNPLA3 variants in a human biomimetic liver microphysiology system for metabolic dysfunction-associated steatotic liver disease precision therapy.
Xia M, Varmazyad M, Pla-Palacín I, Gavlock DC, DeBiasio R, LaRocca G, Reese C, Florentino RM, Faccioli LAP, Brown JA, Vernetti LA, Schurdak M, Stern AM, Gough A, Behari J, Soto-Gutierrez A, Taylor DL, Miedel MT. Xia M, et al. Among authors: florentino rm. Front Cell Dev Biol. 2024 Sep 11;12:1423936. doi: 10.3389/fcell.2024.1423936. eCollection 2024. Front Cell Dev Biol. 2024. PMID: 39324073 Free PMC article.
Human-induced pluripotent stem cell-based hepatic modeling of lipid metabolism-associated TM6SF2-E167K variant.
Faccioli LAP, Sun Y, Animasahun O, Motomura T, Liu Z, Kurihara T, Hu Z, Yang B, Cetin Z, Baratta AM, Shankaran A, Nenwani M, Altay LN, Huang L, Meurs N, Franks J, Stolz D, Gavlock DC, Miedel MT, Ostrowska A, Florentino RM, Fox IJ, Nagrath D, Soto-Gutierrez A. Faccioli LAP, et al. Among authors: florentino rm. Hepatology. 2024 Aug 27:10.1097/HEP.0000000000001065. doi: 10.1097/HEP.0000000000001065. Online ahead of print. Hepatology. 2024. PMID: 39190693
Polymorphisms Associated With Metabolic Dysfunction-Associated Steatotic Liver Disease Influence the Progression of End-Stage Liver Disease.
Kocas-Kilicarslan ZN, Cetin Z, Faccioli LAP, Motomura T, Amirneni S, Diaz-Aragon R, Florentino RM, Sun Y, Pla-Palacin I, Xia M, Miedel MT, Kurihara T, Hu Z, Ostrowska A, Wang Z, Constantine R, Li A, Taylor DL, Behari J, Soto-Gutierrez A, Tafaleng EN. Kocas-Kilicarslan ZN, et al. Among authors: florentino rm. Gastro Hep Adv. 2024;3(1):67-77. doi: 10.1016/j.gastha.2023.09.011. Epub 2023 Oct 5. Gastro Hep Adv. 2024. PMID: 38292457 Free PMC article.
Human Induced Pluripotent Stem Cell based Hepatic-Modeling of Lipid metabolism associated TM6SF2 E167K variant.
Faccioli LA, Sun Y, Motomura T, Liu Z, Kurihara T, Hu Z, Cetin Z, Franks J, Stolz D, Ostrowska A, Florentino RM, Fox IJ, Soto-Gutierrez A. Faccioli LA, et al. Among authors: florentino rm. bioRxiv [Preprint]. 2023 Dec 18:2023.12.18.572248. doi: 10.1101/2023.12.18.572248. bioRxiv. 2023. Update in: Hepatology. 2024 Aug 27. doi: 10.1097/HEP.0000000000001065. PMID: 38187603 Free PMC article. Updated. Preprint.
VEGFA mRNA-LNP promotes biliary epithelial cell-to-hepatocyte conversion in acute and chronic liver diseases and reverses steatosis and fibrosis.
Rizvi F, Lee YR, Diaz-Aragon R, Bawa PS, So J, Florentino RM, Wu S, Sarjoo A, Truong E, Smith AR, Wang F, Everton E, Ostrowska A, Jung K, Tam Y, Muramatsu H, Pardi N, Weissman D, Soto-Gutierrez A, Shin D, Gouon-Evans V. Rizvi F, et al. Among authors: florentino rm. Cell Stem Cell. 2023 Dec 7;30(12):1640-1657.e8. doi: 10.1016/j.stem.2023.10.008. Epub 2023 Nov 28. Cell Stem Cell. 2023. PMID: 38029740 Free PMC article.
Evaluation of Human Hepatocyte Drug Metabolism Carrying High-Risk or Protection-Associated Liver Disease Genetic Variants.
Faccioli LAP, Cetin Z, Kocas-Kilicarslan ZN, Ortiz K, Sun Y, Hu Z, Kurihara T, Tafaleng EN, Florentino RM, Wang Z, Xia M, Miedel MT, Taylor DL, Behari J, Ostrowska A, Constantine R, Li A, Soto-Gutierrez A. Faccioli LAP, et al. Among authors: florentino rm. Int J Mol Sci. 2023 Aug 29;24(17):13406. doi: 10.3390/ijms241713406. Int J Mol Sci. 2023. PMID: 37686209 Free PMC article.
Human Hepatocellular response in Cholestatic Liver Diseases.
Ortiz K, Cetin Z, Sun Y, Hu Z, Kurihara T, Tafaleng EN, Florentino RM, Ostrowska A, Soto-Gutierrez A, Faccioli LAP. Ortiz K, et al. Among authors: florentino rm. Organogenesis. 2023 Dec 31;19(1):2247576. doi: 10.1080/15476278.2023.2247576. Organogenesis. 2023. PMID: 37598346 Free PMC article.
VEGFA mRNA-LNP promotes biliary epithelial cell-to-hepatocyte conversion in acute and chronic liver diseases and reverses steatosis and fibrosis.
Rizvi F, Lee YR, Diaz-Aragon R, So J, Florentino RM, Smith AR, Everton E, Ostrowska A, Jung K, Tam Y, Muramatsu H, Pardi N, Weissman D, Soto-Gutierrez A, Shin D, Gouon-Evans V. Rizvi F, et al. Among authors: florentino rm. bioRxiv [Preprint]. 2023 Apr 18:2023.04.17.537186. doi: 10.1101/2023.04.17.537186. bioRxiv. 2023. Update in: Cell Stem Cell. 2023 Dec 7;30(12):1640-1657.e8. doi: 10.1016/j.stem.2023.10.008. PMID: 37131823 Free PMC article. Updated. Preprint.
Therapeutic treatment with phosphodiesterase-4 inhibitors alleviates kidney injury and renal fibrosis by increasing MMP-9 in a doxorubicin-induced nephrotoxicity mouse model.
Costa WC, Beltrami VA, Campolina-Silva GH, Queiroz-Junior CM, Florentino RM, Machado JR, Martins DG, Gonçalves WA, Barroso LC, Freitas KM, de Souza-Neto FP, Félix FB, da Silva RF, Oliveira CA, Câmara NOS, Rachid MA, Teixeira MM, Rezende BM, Pinho V. Costa WC, et al. Among authors: florentino rm. Int Immunopharmacol. 2023 Feb;115:109583. doi: 10.1016/j.intimp.2022.109583. Epub 2023 Jan 5. Int Immunopharmacol. 2023. PMID: 36610330 Free article.
Biofabrication of synthetic human liver tissue with advanced programmable functions.
Florentino RM, Morita K, Haep N, Motomura T, Diaz-Aragon R, Faccioli LAP, Collin de l'Hortet A, Cetin Z, Frau C, Vernetti L, Amler AK, Thomas A, Lam T, Kloke L, Takeishi K, Taylor DL, Fox IJ, Soto-Gutierrez A. Florentino RM, et al. iScience. 2022 Nov 4;25(12):105503. doi: 10.1016/j.isci.2022.105503. eCollection 2022 Dec 22. iScience. 2022. PMID: 36404924 Free PMC article.
From a Single Cell to a Whole Human Liver: Disease Modeling and Transplantation.
Motomura T, Faccioli LAP, Diaz-Aragon R, Kocas-Kilicarslan ZN, Haep N, Florentino RM, Amirneni S, Cetin Z, Peri BS, Morita K, Ostrowska A, Takeishi K, Soto-Gutierrez A, Tafaleng EN. Motomura T, et al. Among authors: florentino rm. Semin Liver Dis. 2022 Nov;42(4):413-422. doi: 10.1055/a-1934-5404. Epub 2022 Aug 31. Semin Liver Dis. 2022. PMID: 36044927 Free PMC article.
Therapeutic Potential of HNF4α in End-stage Liver Disease.
Diaz-Aragon R, Coard MC, Amirneni S, Faccioli L, Haep N, Malizio MR, Motomura T, Kocas-Kilicarslan ZN, Ostrowska A, Florentino RM, Frau C. Diaz-Aragon R, et al. Among authors: florentino rm. Organogenesis. 2021 Oct 2;17(3-4):126-135. doi: 10.1080/15476278.2021.1994273. Organogenesis. 2021. PMID: 35114889 Free PMC article. Review.
Human Hepatocytes Isolated from Explanted Livers: A Powerful Tool to Understand End-stage Liver Disease and Drug Screening.
Faccioli LAP, Kocas-Kilicarslan ZN, Diaz-Aragon R, Motomura T, Amirneni S, Malizio MR, Coard MC, Frau C, Haep N, Florentino RM, Ostrowska A. Faccioli LAP, et al. Among authors: florentino rm. Organogenesis. 2021 Oct 2;17(3-4):117-125. doi: 10.1080/15476278.2021.1992216. Organogenesis. 2021. PMID: 35114888 Free PMC article. Review.
Inositol 1,4,5-trisphosphate receptor type 3 is involved in resistance to apoptosis and maintenance of human hepatocellular carcinoma.
Dos Santos ML, França A, Lima Filho ACM, Florentino RM, Diniz PH, Oliveira Lemos F, Gonçalves CAX, Coelho VL, Lima CX, Foureaux G, Nathanson MH, Vidigal PVT, Leite MF. Dos Santos ML, et al. Among authors: florentino rm. Oncol Lett. 2022 Jan;23(1):32. doi: 10.3892/ol.2021.13150. Epub 2021 Nov 25. Oncol Lett. 2022. PMID: 34966448 Free PMC article.
Hepatocyte Nuclear Factor 4 alpha 2 Messenger RNA Reprograms Liver-Enriched Transcription Factors and Functional Proteins in End-Stage Cirrhotic Human Hepatocytes.
Tafaleng EN, Mukherjee A, Bell A, Morita K, Guzman-Lepe J, Haep N, Florentino RM, Diaz-Aragon R, Frau C, Ostrowska A, Schultz JR, Martini PGV, Soto-Gutierrez A, Fox IJ. Tafaleng EN, et al. Among authors: florentino rm. Hepatol Commun. 2021 Nov;5(11):1911-1926. doi: 10.1002/hep4.1763. Epub 2021 Jul 1. Hepatol Commun. 2021. PMID: 34558820 Free PMC article.
The Inside-Out of End-Stage Liver Disease: Hepatocytes are the Keystone.
Haep N, Florentino RM, Squires JE, Bell A, Soto-Gutierrez A. Haep N, et al. Among authors: florentino rm. Semin Liver Dis. 2021 May;41(2):213-224. doi: 10.1055/s-0041-1725023. Epub 2021 May 15. Semin Liver Dis. 2021. PMID: 33992030 Free PMC article. Review.
Molecular overview of progressive familial intrahepatic cholestasis.
Amirneni S, Haep N, Gad MA, Soto-Gutierrez A, Squires JE, Florentino RM. Amirneni S, et al. Among authors: florentino rm. World J Gastroenterol. 2020 Dec 21;26(47):7470-7484. doi: 10.3748/wjg.v26.i47.7470. World J Gastroenterol. 2020. PMID: 33384548 Free PMC article. Review.
Inositol 1,4,5-trisphosphate receptor type 3 plays a protective role in hepatocytes during hepatic ischemia-reperfusion injury.
Lima Filho ACM, França A, Florentino RM, Dos Santos ML, de Oliveira Lemos F, Missiaggia DG, Fonseca RC, Gustavo Oliveira A, Ananthanarayanan M, Guerra MT, de Castro Fonseca M, Vidigal PVT, Lima CX, Nathanson MH, Fatima Leite M. Lima Filho ACM, et al. Among authors: florentino rm. Cell Calcium. 2020 Nov;91:102264. doi: 10.1016/j.ceca.2020.102264. Epub 2020 Aug 11. Cell Calcium. 2020. PMID: 32957029 Free PMC article.
Correction to: A role for mast cells and mast cell tryptase in driving neutrophil recruitment in LPS-induced lung inflammation via protease-activated receptor 2 in mice.
de Almeida AD, Silva IS, Fernandes-Braga W, LimaFilho ACM, Florentino RM, Barra A, de Oliveira Andrade L, Leite MF, Cassali GD, Klein A. de Almeida AD, et al. Among authors: florentino rm. Inflamm Res. 2020 Oct;69(10):1071. doi: 10.1007/s00011-020-01386-2. Inflamm Res. 2020. PMID: 32767096
Assembly and Function of a Bioengineered Human Liver for Transplantation Generated Solely from Induced Pluripotent Stem Cells.
Takeishi K, Collin de l'Hortet A, Wang Y, Handa K, Guzman-Lepe J, Matsubara K, Morita K, Jang S, Haep N, Florentino RM, Yuan F, Fukumitsu K, Tobita K, Sun W, Franks J, Delgado ER, Shapiro EM, Fraunhoffer NA, Duncan AW, Yagi H, Mashimo T, Fox IJ, Soto-Gutierrez A. Takeishi K, et al. Among authors: florentino rm. Cell Rep. 2020 Jun 2;31(9):107711. doi: 10.1016/j.celrep.2020.107711. Cell Rep. 2020. PMID: 32492423 Free PMC article.
Cellular Location of HNF4α is Linked With Terminal Liver Failure in Humans.
Florentino RM, Fraunhoffer NA, Morita K, Takeishi K, Ostrowska A, Achreja A, Animasahun O, Haep N, Arazov S, Agarwal N, Collin de l'Hortet A, Guzman-Lepe J, Tafaleng EN, Mukherjee A, Troy K, Banerjee S, Paranjpe S, Michalopoulos GK, Bell A, Nagrath D, Hainer SJ, Fox IJ, Soto-Gutierrez A. Florentino RM, et al. Hepatol Commun. 2020 Apr 21;4(6):859-875. doi: 10.1002/hep4.1505. eCollection 2020 Jun. Hepatol Commun. 2020. PMID: 32490322 Free PMC article.
Molecular Mechanism for Protection Against Liver Failure in Human Yellow Fever Infection.
Lemos FO, França A, Lima Filho ACM, Florentino RM, Santos ML, Missiaggia DG, Rodrigues GOL, Dias FF, Souza Passos IB, Teixeira MM, Andrade AMF, Lima CX, Vidigal PVT, Costa VV, Fonseca MC, Nathanson MH, Leite MF. Lemos FO, et al. Among authors: florentino rm. Hepatol Commun. 2020 Mar 16;4(5):657-669. doi: 10.1002/hep4.1504. eCollection 2020 May. Hepatol Commun. 2020. PMID: 32363317 Free PMC article.
Polymorphism in the Promoter Region of NFE2L2 Gene Is a Genetic Marker of Susceptibility to Cirrhosis Associated with Alcohol Abuse.
Nunes Dos Santos K, Florentino RM, França A, Lima Filho ACM, Santos MLD, Missiaggia D, Fonseca MC, Brasil Costa I, Vidigal PVT, Nathanson MH, Lemos FO, Leite MF. Nunes Dos Santos K, et al. Among authors: florentino rm. Int J Mol Sci. 2019 Jul 23;20(14):3589. doi: 10.3390/ijms20143589. Int J Mol Sci. 2019. PMID: 31340446 Free PMC article.
Expression of the type 3 InsP3 receptor is a final common event in the development of hepatocellular carcinoma.
Guerra MT, Florentino RM, Franca A, Lima Filho AC, Dos Santos ML, Fonseca RC, Lemos FO, Fonseca MC, Kruglov E, Mennone A, Njei B, Gibson J, Guan F, Cheng YC, Ananthanarayanan M, Gu J, Jiang J, Zhao H, Lima CX, Vidigal PT, Oliveira AG, Nathanson MH, Leite MF. Guerra MT, et al. Among authors: florentino rm. Gut. 2019 Sep;68(9):1676-1687. doi: 10.1136/gutjnl-2018-317811. Epub 2019 Jul 17. Gut. 2019. PMID: 31315892 Free PMC article.
Cholesterol-enriched membrane microdomains are needed for insulin signaling and proliferation in hepatic cells.
Fonseca MC, França A, Florentino RM, Fonseca RC, Lima Filho ACM, Vidigal PTV, Oliveira AG, Dubuquoy L, Nathanson MH, Leite MF. Fonseca MC, et al. Among authors: florentino rm. Am J Physiol Gastrointest Liver Physiol. 2018 Jul 1;315(1):G80-G94. doi: 10.1152/ajpgi.00008.2018. Epub 2018 Feb 22. Am J Physiol Gastrointest Liver Physiol. 2018. PMID: 29471671 Free PMC article.
Angiotensin Converting Enzyme Regulates Cell Proliferation and Migration.
Alvarenga EC, Fonseca MC, Carvalho CC, Florentino RM, França A, Matias E, Guimarães PB, Batista C, Freire V, Carmona AK, Pesquero JB, de Paula AM, Foureaux G, Leite MF. Alvarenga EC, et al. Among authors: florentino rm. PLoS One. 2016 Dec 19;11(12):e0165371. doi: 10.1371/journal.pone.0165371. eCollection 2016. PLoS One. 2016. PMID: 27992423 Free PMC article.