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Year Number of Results
1995 2
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2003 3
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2005 2
2006 5
2007 1
2008 3
2009 2
2010 1
2011 3
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85 results

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Page 1
A comparison of the risk of QT prolongation among SSRIs.
Funk KA, Bostwick JR. Funk KA, et al. Ann Pharmacother. 2013 Oct;47(10):1330-41. doi: 10.1177/1060028013501994. Epub 2013 Oct 21. Ann Pharmacother. 2013. PMID: 24259697 Review.
DATA SYNTHESIS: Studies demonstrate possible dose-related clinically significant QT prolongation with escitalopram. Fluoxetine, fluvoxamine, and sertraline at traditional doses demonstrate a lack of clinically significant increases in QTc in the majority of studies. …
DATA SYNTHESIS: Studies demonstrate possible dose-related clinically significant QT prolongation with escitalopram. Fluoxetine …
Meta-analysis of selective serotonin reuptake inhibitor-associated QTc prolongation.
Beach SR, Kostis WJ, Celano CM, Januzzi JL, Ruskin JN, Noseworthy PA, Huffman JC. Beach SR, et al. J Clin Psychiatry. 2014 May;75(5):e441-9. doi: 10.4088/JCP.13r08672. J Clin Psychiatry. 2014. PMID: 24922496
OBJECTIVE: To evaluate the association between selective serotonin reuptake inhibitors (SSRIs) and corrected QT interval (QTc) prolongation via meta-analysis of prospective studies. DATA SOURCES: PubMed/MEDLINE database (January 1, 1975-August 15, 2012), with additional re …
OBJECTIVE: To evaluate the association between selective serotonin reuptake inhibitors (SSRIs) and corrected QT interval (QTc) prolon …
Drug-induced QT interval prolongation and torsades de pointes: Role of the pharmacist in risk assessment, prevention and management.
Tisdale JE. Tisdale JE. Can Pharm J (Ott). 2016 May;149(3):139-52. doi: 10.1177/1715163516641136. Epub 2016 Apr 8. Can Pharm J (Ott). 2016. PMID: 27212965 Free PMC article. Review.
Torsades de pointes (TdP) is a life-threatening arrhythmia associated with prolongation of the corrected QT (QTc) interval on the electrocardiogram. ...Other important pharmacokinetic interactions include antidepressants (bupropion, duloxetine, fluoxetine, pa …
Torsades de pointes (TdP) is a life-threatening arrhythmia associated with prolongation of the corrected QT (QTc) interval on …
Drug-induced Brugada syndrome.
Yap YG, Behr ER, Camm AJ. Yap YG, et al. Europace. 2009 Aug;11(8):989-94. doi: 10.1093/europace/eup114. Epub 2009 May 29. Europace. 2009. PMID: 19482855 Free article. Review.
However, recently, many other pharmacological agents not related to class I anti-arrhythmic agents have been reported to induce Brugada ECG patterns including tricyclic antidepressants, fluoxetine, lithium, trifluoperazine, antihistamines, and cocaine. As published reports …
However, recently, many other pharmacological agents not related to class I anti-arrhythmic agents have been reported to induce Brugada ECG …
Detection of Clinically Significant Drug-Drug Interactions in Fatal Torsades de Pointes: Disproportionality Analysis of the Food and Drug Administration Adverse Event Reporting System.
Ji H, Gong M, Gong L, Zhang N, Zhou R, Deng D, Yang Y, Song L, Jia Y. Ji H, et al. J Med Internet Res. 2025 Mar 25;27:e65872. doi: 10.2196/65872. J Med Internet Res. 2025. PMID: 40132181 Free PMC article.
BACKGROUND: Torsades de pointes (TdP) is a rare yet potentially fatal cardiac arrhythmia that is often drug-induced. ...CONCLUSIONS: Clinical evidence on DDIs is limited, and not all combinations of heart rate-corrected QT interval (QTc)-prolonging drugs result in T …
BACKGROUND: Torsades de pointes (TdP) is a rare yet potentially fatal cardiac arrhythmia that is often drug-induced. ...CONCLUSIONS: …
Deutetrabenazine Therapy and CYP2D6 Genotype.
Dean L. Dean L. 2019 May 1. In: Pratt VM, Scott SA, Pirmohamed M, Esquivel B, Kattman BL, Malheiro AJ, editors. Medical Genetics Summaries [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2012–. 2019 May 1. In: Pratt VM, Scott SA, Pirmohamed M, Esquivel B, Kattman BL, Malheiro AJ, editors. Medical Genetics Summaries [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2012–. PMID: 31046213 Free Books & Documents. Review.
The 2018 FDA-approved drug label for deutetrabenazine states that the daily dose of deutetrabenazine should not exceed 36 mg (maximum single dose of 18 mg) for individuals who are CYP2D6 poor metabolizers or concurrently taking a strong CYP2D6 inhibitor (e.g., quinidine, antidepr …
The 2018 FDA-approved drug label for deutetrabenazine states that the daily dose of deutetrabenazine should not exceed 36 mg (maximum single …
Central actions of serotonin and fluoxetine on the QT interval of the electrocardiogram in trout.
Kermorgant M, Lancien F, Mimassi N, Le Mével JC. Kermorgant M, et al. Comp Biochem Physiol C Toxicol Pharmacol. 2015 Jan;167:190-9. doi: 10.1016/j.cbpc.2014.10.007. Comp Biochem Physiol C Toxicol Pharmacol. 2015. PMID: 25445020
In humans, prolongation of the QT interval is a known clinical risk factor for the development of ventricular arrhythmias including 'Torsades de Pointes' and possible sudden cardiac death. After oral administration, fluoxetine (FLX), as well as other selectiv …
In humans, prolongation of the QT interval is a known clinical risk factor for the development of ventricular arrhythmias including ' …
Restoring the two pivotal fluoxetine trials in children and adolescents with depression.
Gøtzsche PC, Healy D. Gøtzsche PC, et al. Int J Risk Saf Med. 2022;33(4):385-408. doi: 10.3233/JRS-210034. Int J Risk Saf Med. 2022. PMID: 35786661
Fluoxetine reduced height and weight over 19 weeks by 1.0 cm and 1.1 kg, respectively, and prolonged the QT interval. CONCLUSIONS: Our reanalysis of the two pivotal trials showed that fluoxetine is unsafe and ineffective....
Fluoxetine reduced height and weight over 19 weeks by 1.0 cm and 1.1 kg, respectively, and prolonged the QT interval. CONCLUSI …
Correlation Between Escitalopram, Sertraline, and Fluoxetine Serum Levels and QTc Interval Prolongation in Children and Adolescents.
Warrings W, Taurines R, Egberts K, Keicher F, Romanos M, Fekete S. Warrings W, et al. Ther Drug Monit. 2026 Jun 1;48(3):366-372. doi: 10.1097/FTD.0000000000001379. Epub 2025 Sep 26. Ther Drug Monit. 2026. PMID: 41004670
These medications are associated with potential cardiac side effects, particularly corrected QT (QTc) interval prolongation. This study is the first to evaluate the association between serum concentrations of escitalopram, sertraline, and fluoxetine and QTc interval …
These medications are associated with potential cardiac side effects, particularly corrected QT (QTc) interval prolongation. This stu …
Thioridazine Therapy and CYP2D6 Genotypes.
Dean L, Kane M. Dean L, et al. 2017 Feb 9 [updated 2026 Jan 14]. In: Pratt VM, Scott SA, Pirmohamed M, Esquivel B, Kattman BL, Malheiro AJ, editors. Medical Genetics Summaries [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2012–. 2017 Feb 9 [updated 2026 Jan 14]. In: Pratt VM, Scott SA, Pirmohamed M, Esquivel B, Kattman BL, Malheiro AJ, editors. Medical Genetics Summaries [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2012–. PMID: 28520378 Free Books & Documents. Review.
Thioridazine has been shown to prolong the QT interval (the time taken for the heart ventricles to depolarize and repolarize) in a dose related manner. ...The label also states it is contraindicated to administer thioridazine with drugs that inhibit CYP2D6 (for example, …
Thioridazine has been shown to prolong the QT interval (the time taken for the heart ventricles to depolarize and repolarize) in a do …
85 results