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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1983 1
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1985 3
1987 3
1988 1
1991 3
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1993 1
1994 1
1995 1
1996 1
1999 1
2000 1
2002 1
2004 2
2007 1
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2012 3
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2018 1
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40 results

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Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Flupirtine in the treatment of post-operative pain.
Riethmüller-Winzen H. Riethmüller-Winzen H. Postgrad Med J. 1987;63 Suppl 3:61-5. Postgrad Med J. 1987. PMID: 3328853 Review.
Flupirtine maleate (referred to throughout this paper as flupirtine) capsules 100 mg and suppositories 150 mg were found to be safe and efficacious in several randomized, controlled, double-blind parallel group clinical trials. 586 patients (40 children) suffering f …
Flupirtine maleate (referred to throughout this paper as flupirtine) capsules 100 mg and suppositories 150 mg were found to be …
Pharmacokinetic profiles of the analgesic drug flupirtine in cats.
De Vito V, Lebkowska-Wieruszewska B, Owen H, Kowalski CJ, Giorgi M. De Vito V, et al. Vet J. 2014 Nov;202(2):309-13. doi: 10.1016/j.tvjl.2014.06.011. Epub 2014 Jun 16. Vet J. 2014. PMID: 25011711 Clinical Trial.
Flupirtine (FLU) is a non-opioid analgesic drug with no antipyretic or antiphlogistic effects, used in the treatment of a wide range of pain states in human beings. ...
Flupirtine (FLU) is a non-opioid analgesic drug with no antipyretic or antiphlogistic effects, used in the treatment of a wide range …
Comparison of flupirtine maleate and dihydrocodeine in patients following surgery.
Moore RA, Bullingham RE, Simpson S, O'Sullivan G, Evans PJ, McQuay HJ, Lloyd JW. Moore RA, et al. Br J Anaesth. 1983 May;55(5):429-32. doi: 10.1093/bja/55.5.429. Br J Anaesth. 1983. PMID: 6342637 Free article. Clinical Trial.
Flupirtine maleate 100 mg was compared with dihydrocodeine 60 mg when given by mouth to 50 women on the first 3 days following abdominal hysterectomy in a double-blind parallel-group trial. ...The only significant differences in side-effects were an increased frequency of …
Flupirtine maleate 100 mg was compared with dihydrocodeine 60 mg when given by mouth to 50 women on the first 3 days following abdomi …
Activation of axonal Kv7 channels in human peripheral nerve by flupirtine but not placebo - therapeutic potential for peripheral neuropathies: results of a randomised controlled trial.
Fleckenstein J, Sittl R, Averbeck B, Lang PM, Irnich D, Carr RW. Fleckenstein J, et al. J Transl Med. 2013 Feb 8;11:34. doi: 10.1186/1479-5876-11-34. J Transl Med. 2013. PMID: 23394517 Free PMC article. Clinical Trial.
BACKGROUND: Flupirtine is an analgesic with muscle-relaxing properties that activates Kv7 potassium channels. ...Finally, visual analogue scale ratings of sensations perceived during the post-ischemic period were reduced following flupirtine (200 mg p.o.). CONCLUSIO …
BACKGROUND: Flupirtine is an analgesic with muscle-relaxing properties that activates Kv7 potassium channels. ...Finally, visual anal …
Dose-related analgesic effects of flupirtine.
Hummel T, Friedmann T, Pauli E, Niebch G, Borbe HO, Kobal G. Hummel T, et al. Br J Clin Pharmacol. 1991 Jul;32(1):69-76. doi: 10.1111/j.1365-2125.1991.tb05615.x. Br J Clin Pharmacol. 1991. PMID: 1888644 Free PMC article. Clinical Trial.
1. Flupirtine is a novel and, in all probability, centrally acting, analgesic. The present investigation was conducted in order to investigate dose-related effects of perorally administered flupirtine in man, with special regard to specifically analgesic actions, em …
1. Flupirtine is a novel and, in all probability, centrally acting, analgesic. The present investigation was conducted in order to in …
Clinical trial of flupirtine maleate in patients with migraine.
Million R, Finlay BR, Whittington JR. Million R, et al. Curr Med Res Opin. 1984;9(3):204-12. doi: 10.1185/03007998409109581. Curr Med Res Opin. 1984. PMID: 6389014 Clinical Trial.
Despite an initial pain level on the first day of the migraine attack which was significantly higher in the flupirtine group, there were trends for flupirtine patients to show subsequently lower pain scores and to suffer less restriction of working ability and confi …
Despite an initial pain level on the first day of the migraine attack which was significantly higher in the flupirtine group, there w …
The effect of M-current activation on controller gain and obstructive sleep apnoea severity: a randomised controlled trial using flupirtine.
Thomson LDJ, Landry SA, Arellano A, Collet J, Huddle S, O'Driscoll DM, Mann DL, Beatty C, Joosten SA, Hamilton GS, Berger PJ, Cooke I, Edwards BA. Thomson LDJ, et al. J Physiol. 2025 May;603(10):3245-3260. doi: 10.1113/JP288337. Epub 2025 Apr 3. J Physiol. 2025. PMID: 40181609 Free PMC article. Clinical Trial.
The lack of overall efficacy of flupirtine is most likely due to multifactorial nature of OSA and the challenges of its management. ...This research examined whether the drug flupirtine could stabilise breathing control and reduce OSA severity in 15 patients. Flu …
The lack of overall efficacy of flupirtine is most likely due to multifactorial nature of OSA and the challenges of its management. . …
Metabolic activation and analgesic effect of flupirtine in healthy subjects, influence of the polymorphic NAT2, UGT1A1 and GSTP1.
Siegmund W, Modess C, Scheuch E, Methling K, Keiser M, Nassif A, Rosskopf D, Bednarski PJ, Borlak J, Terhaag B. Siegmund W, et al. Br J Clin Pharmacol. 2015 Mar;79(3):501-13. doi: 10.1111/bcp.12522. Br J Clin Pharmacol. 2015. PMID: 25264565 Free PMC article. Clinical Trial.
Analgesic effects were measured using pain models (delayed onset of muscle soreness, electric pain). RESULTS: Flupirtine IR was rapidly but incompletely absorbed ( 72%). Repeated administration of flupirtine MR showed lower bioavailability ( 60%). ...Carriers of v …
Analgesic effects were measured using pain models (delayed onset of muscle soreness, electric pain). RESULTS: Flupirtine IR was rapid …
Trial of oral flupirtine maleate in the treatment of pain after orthopaedic surgery.
Galasko CS, Courtenay PM, Jane M, Stamp TC. Galasko CS, et al. Curr Med Res Opin. 1985;9(9):594-601. doi: 10.1185/03007998509109640. Curr Med Res Opin. 1985. PMID: 3902375 Clinical Trial.
High proportions of patients in each group expressed overall satisfaction with the trial medication, somewhat more so with flupirtine (85% to 95%) than pentazocine treatment (67% to 79%). Reports of dizziness/lightheadedness were significantly more common with pentazocine …
High proportions of patients in each group expressed overall satisfaction with the trial medication, somewhat more so with flupirtine …
Evaluation of the abuse potential of the novel analgesic flupirtine maleate.
Preston KL, Funderburk FR, Liebson IA, Bigelow GE. Preston KL, et al. Drug Alcohol Depend. 1991 Mar;27(2):101-13. doi: 10.1016/0376-8716(91)90027-v. Drug Alcohol Depend. 1991. PMID: 2055157 Clinical Trial.
To evaluate the psychopharmacological effects and potential abuse liability of the novel analgesic flupirtine maleate the subjective and behavioral effects of orally administered flupirtine, lorazepam and placebo were studied in polydrug abusers. ...Flupirtine …
To evaluate the psychopharmacological effects and potential abuse liability of the novel analgesic flupirtine maleate the subjective …
40 results