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58 results

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Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Biosimilar recombinant follitropin alfa preparations versus the reference product (Gonal-F) in couples undergoing assisted reproductive technology treatment: a systematic review and meta-analysis.
Chua SJ, Mol BW, Longobardi S, Orvieto R, Venetis CA, Lispi M, Storr A, D'Hooghe T. Chua SJ, et al. Reprod Biol Endocrinol. 2021 Apr 2;19(1):51. doi: 10.1186/s12958-021-00727-y. Reprod Biol Endocrinol. 2021. PMID: 33794909 Free PMC article.
However, previous analyses comparing biosimilar preparations of follitropin alfa versus the reference product (GONAL-f, Merck KGaA, Darmstadt, Germany or GONAL-f RFF; EMD Serono, Inc., Rockland, MA), have had insufficient power to detect differences in clinically me …
However, previous analyses comparing biosimilar preparations of follitropin alfa versus the reference product (GONAL-f, Merck …
A randomised controlled trial to clinically validate follitropin delta in its individualised dosing regimen for ovarian stimulation in Asian IVF/ICSI patients.
Qiao J, Zhang Y, Liang X, Ho T, Huang HY, Kim SH, Goethberg M, Mannaerts B, Arce JC. Qiao J, et al. Hum Reprod. 2021 Aug 18;36(9):2452-2462. doi: 10.1093/humrep/deab155. Hum Reprod. 2021. PMID: 34179971 Free PMC article. Clinical Trial.
STUDY QUESTION: Is ovarian stimulation with follitropin delta in its individualised fixed-dose regimen at least as efficacious as follitropin alfa in a conventional dosing regimen in Asian population? ...Non-inferiority of follitropin delta in its indi …
STUDY QUESTION: Is ovarian stimulation with follitropin delta in its individualised fixed-dose regimen at least as efficacious as …
Biosimilars versus the originator of follitropin alfa for ovarian stimulation in ART: a systematic review and meta-analysis.
Kiose KI, Storr A, Kolibianakis EM, Mol BW, Venetis CA. Kiose KI, et al. Hum Reprod. 2025 Feb 1;40(2):343-359. doi: 10.1093/humrep/deae274. Hum Reprod. 2025. PMID: 39719046 Free PMC article.
STUDY QUESTION: Is the probability of pregnancy different between women using biosimilars versus the originator of follitropin alfa for ovarian stimulation in ART? SUMMARY ANSWER: Meta-analysis of eight randomized clinical trials (RCTs) suggests that live birth, cli …
STUDY QUESTION: Is the probability of pregnancy different between women using biosimilars versus the originator of follitropin alf …
Outcomes of new quality standards of follitropin alfa on ovarian stimulation: meta-analysis of previous studies.
Saz-Parkinson Z, López-Cuadrado T, Bouza C, Amate JM. Saz-Parkinson Z, et al. BioDrugs. 2009;23(1):37-42. doi: 10.2165/00063030-200923010-00004. BioDrugs. 2009. PMID: 19344190 Review.
Several clinical trials have tried to assess the clinical implications of the physicochemical improvements in the dosing of follitropin alfa filled by mass (FbM). The aim of this study was to perform a meta-analysis of previous studies in order to assess the efficac …
Several clinical trials have tried to assess the clinical implications of the physicochemical improvements in the dosing of follitropin …
Individualized versus conventional ovarian stimulation for in vitro fertilization: a multicenter, randomized, controlled, assessor-blinded, phase 3 noninferiority trial.
Nyboe Andersen A, Nelson SM, Fauser BC, García-Velasco JA, Klein BM, Arce JC; ESTHER-1 study group. Nyboe Andersen A, et al. Fertil Steril. 2017 Feb;107(2):387-396.e4. doi: 10.1016/j.fertnstert.2016.10.033. Epub 2016 Nov 29. Fertil Steril. 2017. PMID: 27912901 Free article. Clinical Trial.
OBJECTIVE: To compare the efficacy and safety of follitropin delta, a new human recombinant FSH with individualized dosing based on serum antimullerian hormone (AMH) and body weight, with conventional follitropin alfa dosing for ovarian stimulation in women u …
OBJECTIVE: To compare the efficacy and safety of follitropin delta, a new human recombinant FSH with individualized dosing based on s …
Corifollitropin alfa compared with follitropin beta in poor responders undergoing ICSI: a randomized controlled trial.
Kolibianakis EM, Venetis CA, Bosdou JK, Zepiridis L, Chatzimeletiou K, Makedos A, Masouridou S, Triantafillidis S, Mitsoli A, Tarlatzis BC. Kolibianakis EM, et al. Hum Reprod. 2015 Feb;30(2):432-40. doi: 10.1093/humrep/deu301. Epub 2014 Dec 9. Hum Reprod. 2015. PMID: 25492411 Clinical Trial.
SUMMARY ANSWER: A single s.c. dose of 150 g corifollitropin alfa on the first day of ovarian stimulation, followed if necessary, from Day 8 onwards, with 450 IU of follitropin beta/day, is not inferior to daily doses of 450 IU follitropin beta. ...On Day 2 of …
SUMMARY ANSWER: A single s.c. dose of 150 g corifollitropin alfa on the first day of ovarian stimulation, followed if necessary, from …
Efficacy and safety of follitropin alfa/lutropin alfa in ART: a randomized controlled trial in poor ovarian responders.
Humaidan P, Chin W, Rogoff D, D'Hooghe T, Longobardi S, Hubbard J, Schertz J; ESPART Study Investigators‡. Humaidan P, et al. Hum Reprod. 2017 Mar 1;32(3):544-555. doi: 10.1093/humrep/dew360. Hum Reprod. 2017. PMID: 28137754 Free PMC article. Clinical Trial.
STUDY QUESTION: How does the efficacy and safety of a fixed-ratio combination of recombinant human FSH plus recombinant human LH (follitropin alfa plus lutropin alfa; r-hFSH/r-hLH) compare with that of r-hFSH monotherapy for controlled ovarian stimulation (CO …
STUDY QUESTION: How does the efficacy and safety of a fixed-ratio combination of recombinant human FSH plus recombinant human LH (follitr …
Efficacy and safety of follitropin delta for ovarian stimulation in vitro fertilization/ intracytoplasmic sperm injection cycles: a systematic review with meta-analysis.
Palomba S, Caserta D, Levi-Setti PE, Busnelli A. Palomba S, et al. J Ovarian Res. 2024 Mar 14;17(1):60. doi: 10.1186/s13048-024-01372-w. J Ovarian Res. 2024. PMID: 38486276 Free PMC article. Review.
All trials compared personalized recombinant follitropin delta treatment versus conventional recombinant follitropin alfa/beta administration in potentially normo-responder patients who receive ovarian stimulation in GnRH antagonist IVF/ICSI cycles. ...CONCLU …
All trials compared personalized recombinant follitropin delta treatment versus conventional recombinant follitropin alfa …
Comparative clinical outcome following individualized follitropin delta dosing in Chinese women undergoing ovarian stimulation for in vitro fertilization /intracytoplasmic sperm injection.
Yang R, Zhang Y, Liang X, Song X, Wei Z, Liu J, Yang Y, Tan J, Zhang Q, Sun Y, Wang W, Qian W, Jin L, Wang S, Xu Y, Yang J, Goethberg M, Mannaerts B, Wu W, Zheng Z, Qiao J. Yang R, et al. Reprod Biol Endocrinol. 2022 Oct 4;20(1):147. doi: 10.1186/s12958-022-01016-y. Reprod Biol Endocrinol. 2022. PMID: 36195924 Free PMC article. Clinical Trial.
BACKGROUND: To compare the efficacy and safety of follitropin delta in its individualized fixed-dose regimen with follitropin alfa in a conventional adjustable dosing regimen in Chinese women. ...The clinical pregnancy rate (35.4% vs. 31.5%, P = 0.239) and li …
BACKGROUND: To compare the efficacy and safety of follitropin delta in its individualized fixed-dose regimen with follitropin …
Follitropin delta in repeated ovarian stimulation for IVF: a controlled, assessor-blind Phase 3 safety trial.
Bosch E, Havelock J, Martin FS, Rasmussen BB, Klein BM, Mannaerts B, Arce JC; ESTHER-2 Study Group. Bosch E, et al. Reprod Biomed Online. 2019 Feb;38(2):195-205. doi: 10.1016/j.rbmo.2018.10.012. Epub 2018 Dec 14. Reprod Biomed Online. 2019. PMID: 30594482 Free article. Clinical Trial.
RESEARCH QUESTION: To evaluate the immunogenicity of follitropin delta in repeated ovarian stimulation. DESIGN: Controlled, assessor-blind trial in IVF/intracytoplasmic sperm injection patients undergoing repeated cycles of ovarian stimulation (cycles 2 and 3), following i …
RESEARCH QUESTION: To evaluate the immunogenicity of follitropin delta in repeated ovarian stimulation. DESIGN: Controlled, assessor- …
58 results