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Page 1
FIGNL1 inhibits homologous recombination in BRCA2 deficient cells by dissociating RAD51 filaments.
Kuthethur R, Vz SN, Sengodan SK, Fonseca C, Braunshier S, Nagar N, Acharya A, Wang X, Theil AF, Ibini O, Manolika EM, de Koning K, Dessapt J, Fradet-Turcotte A, Lebbink JHG, Kanaar R, Poluri KM, Sharan SK, Cejka P, Ray Chaudhuri A. Kuthethur R, et al. Science. 2025 Oct 30;390(6772):eadt1210. doi: 10.1126/science.adt1210. Epub 2025 Oct 30. Science. 2025. PMID: 41166468
Retraction.
Orthwein A, Fradet-Turcotte A, Noordermeer SM, Canny MD, Brun CM, Strecker J, Escribano-Diaz C, Durocher D. Orthwein A, et al. Science. 2025 Jan 10;387(6730):147. doi: 10.1126/science.adv1263. Epub 2025 Jan 9. Science. 2025. PMID: 39787242 No abstract available.
FIRRM cooperates with FIGNL1 to promote RAD51 disassembly during DNA repair.
Pinedo-Carpio E, Dessapt J, Beneyton A, Sacre L, Bérubé MA, Villot R, Lavoie EG, Coulombe Y, Blondeau A, Boulais J, Malina A, Luo VM, Lazaratos AM, Côté JF, Mallette FA, Guarné A, Masson JY, Fradet-Turcotte A, Orthwein A. Pinedo-Carpio E, et al. Sci Adv. 2023 Aug 9;9(32):eadf4082. doi: 10.1126/sciadv.adf4082. Epub 2023 Aug 9. Sci Adv. 2023. PMID: 37556550 Free PMC article.
FIRRM/C1orf112 is synthetic lethal with PICH and mediates RAD51 dynamics.
Stok C, Tsaridou S, van den Tempel N, Everts M, Wierenga E, Bakker FJ, Kok Y, Alves IT, Jae LT, Raas MWD, Huis In 't Veld PJ, de Boer HR, Bhattacharya A, Karanika E, Warner H, Chen M, van de Kooij B, Dessapt J, Ter Morsche L, Perepelkina P, Fradet-Turcotte A, Guryev V, Tromer EC, Chan KL, Fehrmann RSN, van Vugt MATM. Stok C, et al. Cell Rep. 2023 Jul 25;42(7):112668. doi: 10.1016/j.celrep.2023.112668. Epub 2023 Jun 21. Cell Rep. 2023. PMID: 37347663 Free article.
52 results