Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

My NCBI Filters
Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1995 1
1996 2
1997 1
1998 3
1999 3
2000 1
2001 2
2003 3
2004 4
2005 3
2006 2
2007 3
2008 1
2009 3
2010 4
2011 4
2012 3
2013 7
2014 5
2015 9
2016 6
2017 6
2018 10
2019 4
2020 2
2021 3
2022 2
Text availability
Article attribute
Article type
Publication date

Search Results

88 results
Results by year
Filters applied: . Clear all
Page 1
cGMP: a unique 2nd messenger molecule - recent developments in cGMP research and development.
Friebe A, Sandner P, Schmidtko A. Friebe A, et al. Naunyn Schmiedebergs Arch Pharmacol. 2020 Feb;393(2):287-302. doi: 10.1007/s00210-019-01779-z. Epub 2019 Dec 18. Naunyn Schmiedebergs Arch Pharmacol. 2020. PMID: 31853617 Free PMC article. Review.
Its production is triggered by stimulation of either soluble guanylyl cyclase (sGC) or particulate guanylyl cyclase (pGC); both enzymes exist in different isoforms. cGMP-induced effects are regulated by endogenous receptor ligands such as nitric oxide …
Its production is triggered by stimulation of either soluble guanylyl cyclase (sGC) or particulate guanylyl cyclase (pGC); bot …
NO-sensitive guanylyl cyclase in the lung.
Friebe A, Englert N. Friebe A, et al. Br J Pharmacol. 2022 Jun;179(11):2328-2343. doi: 10.1111/bph.15345. Epub 2021 Jan 15. Br J Pharmacol. 2022. PMID: 33332689 Review.
In the late 1960s, several labatories identified guanylyl cyclase (GC) as the cGMP-producing enzyme. Subsequently, two different types of GC were described that differed in their cellular localization. Primarily found in the cytosol, nitric oxide (NO)-sensiti …
In the late 1960s, several labatories identified guanylyl cyclase (GC) as the cGMP-producing enzyme. Subsequently, two differe …
NO-GC in cells 'off the beaten track'.
Friebe A, Voußen B, Groneberg D. Friebe A, et al. Nitric Oxide. 2018 Jul 1;77:12-18. doi: 10.1016/j.niox.2018.03.020. Epub 2018 Apr 4. Nitric Oxide. 2018. PMID: 29626542 Review.
Nitric oxide-sensitive guanylyl cyclase (NO-GC) has been shown to regulate a plethora of different functions in the body. ...Clearly, individual cell types that express NO-GC contribute differentially to organ-specific NO/cGMP signaling in the body. Hence, id
Nitric oxide-sensitive guanylyl cyclase (NO-GC) has been shown to regulate a plethora of different functions in the body. ...C
Rise of cGMP by partial phosphodiesterase-3A degradation enhances cardioprotection during hypoxia.
Bork NI, Kuret A, Cruz Santos M, Molina CE, Reiter B, Reichenspurner H, Friebe A, Skryabin BV, Rozhdestvensky TS, Kuhn M, Lukowski R, Nikolaev VO. Bork NI, et al. Among authors: friebe a. Redox Biol. 2021 Nov 6;48:102179. doi: 10.1016/j.redox.2021.102179. Online ahead of print. Redox Biol. 2021. PMID: 34763298 Free PMC article.
For example, in myocardial infarction and heart failure (HF), clinical use of cGMP-elevating drugs improves disease outcomes. Although they protect mice from ischemia/reperfusion (I/R) injury, the exact mechanism how cardiac cGMP signaling is regulated in response t …
For example, in myocardial infarction and heart failure (HF), clinical use of cGMP-elevating drugs improves disease outcomes. Althoug …
Nitric oxide-sensitive guanylyl cyclase: structure and regulation.
Koesling D, Russwurm M, Mergia E, Mullershausen F, Friebe A. Koesling D, et al. Among authors: friebe a. Neurochem Int. 2004 Nov;45(6):813-9. doi: 10.1016/j.neuint.2004.03.011. Neurochem Int. 2004. PMID: 15312975 Review.
By the formation of the second messenger cGMP, NO-sensitive guanylyl cyclase (GC) plays a key role within the NO/cGMP signaling cascade which participates in vascular regulation and neurotransmission. ...
By the formation of the second messenger cGMP, NO-sensitive guanylyl cyclase (GC) plays a key role within the NO/cGMP s …
Optical control of a receptor-linked guanylyl cyclase using a photoswitchable peptidic hormone.
Podewin T, Broichhagen J, Frost C, Groneberg D, Ast J, Meyer-Berg H, Fine NHF, Friebe A, Zacharias M, Hodson DJ, Trauner D, Hoffmann-Röder A. Podewin T, et al. Among authors: friebe a. Chem Sci. 2017 Jun 1;8(6):4644-4653. doi: 10.1039/c6sc05044a. Epub 2017 Apr 19. Chem Sci. 2017. PMID: 28626572 Free PMC article.
The endogeneous hormone ANP signals via the natriuretic peptide receptor A (NPR-A) through raising intracellular cGMP concentrations, and is involved in blood pressure regulation and sodium homeostasis, as well as lipid metabolism and pancreatic function. ...Thus, applicat …
The endogeneous hormone ANP signals via the natriuretic peptide receptor A (NPR-A) through raising intracellular cGMP concentrations, …
β3-Adrenoceptor redistribution impairs NO/cGMP/PDE2 signalling in failing cardiomyocytes.
Schobesberger S, Wright PT, Poulet C, Sanchez Alonso Mardones JL, Mansfield C, Friebe A, Harding SE, Balligand JL, Nikolaev VO, Gorelik J. Schobesberger S, et al. Among authors: friebe a. Elife. 2020 Mar 31;9:e52221. doi: 10.7554/eLife.52221. Elife. 2020. PMID: 32228862 Free PMC article.
Cardiomyocyte beta(3)-adrenoceptors (beta(3)-ARs) coupled to soluble guanylyl cyclase (sGC)-dependent production of the second messenger 3',5'-cyclic guanosine monophosphate (cGMP) have been shown to protect from heart failure. ...Furthermore, attenuated cGMP
Cardiomyocyte beta(3)-adrenoceptors (beta(3)-ARs) coupled to soluble guanylyl cyclase (sGC)-dependent production of the second messen …
The enteric nervous system is a potential autoimmune target in multiple sclerosis.
Wunsch M, Jabari S, Voussen B, Enders M, Srinivasan S, Cossais F, Wedel T, Boettner M, Schwarz A, Weyer L, Göcer O, Schroeter M, Maeurer M, Woenckhaus M, Pollok K, Radbruch H, Klotz L, Scholz CJ, Nickel J, Friebe A, Addicks K, Ergün S, Lehmann PV, Kuerten S. Wunsch M, et al. Among authors: friebe a. Acta Neuropathol. 2017 Aug;134(2):281-295. doi: 10.1007/s00401-017-1742-6. Epub 2017 Jun 15. Acta Neuropathol. 2017. PMID: 28620692
In addition to symptoms caused by CNS pathology, the majority of MS patients frequently exhibit gastrointestinal dysfunction, which was previously either explained by the presence of spinal cord lesions or not directly linked to the autoimmune etiology of the disease. Here, we st …
In addition to symptoms caused by CNS pathology, the majority of MS patients frequently exhibit gastrointestinal dysfunction, which was prev …
From bedside to bench--meeting report of the 7th International Conference on cGMP "cGMP: generators, effectors and therapeutic implications" in Trier, Germany, from June 19th to 21st 2015.
Friebe A, Sandner P, Seifert R. Friebe A, et al. Naunyn Schmiedebergs Arch Pharmacol. 2015 Dec;388(12):1237-46. doi: 10.1007/s00210-015-1176-4. Epub 2015 Oct 20. Naunyn Schmiedebergs Arch Pharmacol. 2015. PMID: 26486926 Review.
During the past decade, our knowledge on the physiology, pathophysiology, basic pharmacology, and clinical pharmacology of the second messenger (cGMP) has increased tremendously. It is now well-established that cGMP, generated by soluble and particulate guanylate …
During the past decade, our knowledge on the physiology, pathophysiology, basic pharmacology, and clinical pharmacology of the second messen …
Regulation of nitric oxide-sensitive guanylyl cyclase.
Friebe A, Koesling D. Friebe A, et al. Circ Res. 2003 Jul 25;93(2):96-105. doi: 10.1161/01.RES.0000082524.34487.31. Circ Res. 2003. PMID: 12881475 Review.
In this review, we outline the current knowledge on the regulation of nitric oxide (NO)-sensitive guanylyl cyclase (GC). Besides NO, the physiological activator that binds to the prosthetic heme group of the enzyme, two novel classes of GC activators have been ident …
In this review, we outline the current knowledge on the regulation of nitric oxide (NO)-sensitive guanylyl cyclase (GC). Besid …
88 results