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1995 1
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2003 3
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2005 3
2006 2
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93 results

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Page 1
NO-sensitive guanylyl cyclase in the lung.
Friebe A, Englert N. Friebe A, et al. Br J Pharmacol. 2022 Jun;179(11):2328-2343. doi: 10.1111/bph.15345. Epub 2021 Jan 15. Br J Pharmacol. 2022. PMID: 33332689 Free article. Review.
In the late 1960s, several labatories identified guanylyl cyclase (GC) as the cGMP-producing enzyme. Subsequently, two different types of GC were described that differed in their cellular localization. Primarily found in the cytosol, nitric oxide (NO)-sensiti …
In the late 1960s, several labatories identified guanylyl cyclase (GC) as the cGMP-producing enzyme. Subsequently, two differe …
Loss of soluble guanylyl cyclase in platelets contributes to atherosclerotic plaque formation and vascular inflammation.
Mauersberger C, Sager HB, Wobst J, Dang TA, Lambrecht L, Koplev S, Stroth M, Bettaga N, Schlossmann J, Wunder F, Friebe A, Björkegren JLM, Dietz L, Maas SL, van der Vorst EPC, Sandner P, Soehnlein O, Schunkert H, Kessler T. Mauersberger C, et al. Among authors: friebe a. Nat Cardiovasc Res. 2022 Dec;1(12):1174-1186. doi: 10.1038/s44161-022-00175-w. Epub 2022 Dec 12. Nat Cardiovasc Res. 2022. PMID: 37484062 Free PMC article.
Variants in genes encoding the soluble guanylyl cyclase (sGC) in platelets are associated with coronary artery disease (CAD) risk. ...
Variants in genes encoding the soluble guanylyl cyclase (sGC) in platelets are associated with coronary artery disease (CAD) risk. .. …
cGMP: a unique 2nd messenger molecule - recent developments in cGMP research and development.
Friebe A, Sandner P, Schmidtko A. Friebe A, et al. Naunyn Schmiedebergs Arch Pharmacol. 2020 Feb;393(2):287-302. doi: 10.1007/s00210-019-01779-z. Epub 2019 Dec 18. Naunyn Schmiedebergs Arch Pharmacol. 2020. PMID: 31853617 Free PMC article. Review.
Its production is triggered by stimulation of either soluble guanylyl cyclase (sGC) or particulate guanylyl cyclase (pGC); both enzymes exist in different isoforms. cGMP-induced effects are regulated by endogenous receptor ligands such as nitric oxide …
Its production is triggered by stimulation of either soluble guanylyl cyclase (sGC) or particulate guanylyl cyclase (pGC); bot …
The 10th International Conference on cGMP 2022: recent trends in cGMP research and development-meeting report.
Friebe A, Kraehling JR, Russwurm M, Sandner P, Schmidtko A. Friebe A, et al. Naunyn Schmiedebergs Arch Pharmacol. 2023 Aug;396(8):1669-1686. doi: 10.1007/s00210-023-02484-8. Epub 2023 Apr 20. Naunyn Schmiedebergs Arch Pharmacol. 2023. PMID: 37079081 Free PMC article. Review.
The fundamental understanding of the signaling mediated by nitric oxide-sensitive (soluble) guanylyl cyclase and membrane-associated receptor (particulate) guanylyl cyclase at the molecular and cellular levels, as well as in vivo, especially in disease models …
The fundamental understanding of the signaling mediated by nitric oxide-sensitive (soluble) guanylyl cyclase and membrane-asso …
NO-GC in cells 'off the beaten track'.
Friebe A, Voußen B, Groneberg D. Friebe A, et al. Nitric Oxide. 2018 Jul 1;77:12-18. doi: 10.1016/j.niox.2018.03.020. Epub 2018 Apr 4. Nitric Oxide. 2018. PMID: 29626542 Review.
Nitric oxide-sensitive guanylyl cyclase (NO-GC) has been shown to regulate a plethora of different functions in the body. ...Clearly, individual cell types that express NO-GC contribute differentially to organ-specific NO/cGMP signaling in the body. Hence, id
Nitric oxide-sensitive guanylyl cyclase (NO-GC) has been shown to regulate a plethora of different functions in the body. ...C
Nitric oxide-sensitive guanylyl cyclase: structure and regulation.
Koesling D, Russwurm M, Mergia E, Mullershausen F, Friebe A. Koesling D, et al. Among authors: friebe a. Neurochem Int. 2004 Nov;45(6):813-9. doi: 10.1016/j.neuint.2004.03.011. Neurochem Int. 2004. PMID: 15312975 Review.
By the formation of the second messenger cGMP, NO-sensitive guanylyl cyclase (GC) plays a key role within the NO/cGMP signaling cascade which participates in vascular regulation and neurotransmission. ...
By the formation of the second messenger cGMP, NO-sensitive guanylyl cyclase (GC) plays a key role within the NO/cGMP s …
A modular systems biological modelling framework studies cyclic nucleotide signaling in platelets.
Breitenbach T, Englert N, Osmanoglu Ö, Rukoyatkina N, Wangorsch G, Heinze K, Friebe A, Butt E, Feil R, Dittrich M, Gambaryan S, Dandekar T. Breitenbach T, et al. Among authors: friebe a. J Theor Biol. 2022 Oct 7;550:111222. doi: 10.1016/j.jtbi.2022.111222. Epub 2022 Jul 16. J Theor Biol. 2022. PMID: 35843440 Free article.
BACKGROUND: The cyclic nucleotides cAMP and cGMP inhibit platelet activation. Different platelet signaling modules work together. ...We demonstrate it by a multi-modular model for platelet signaling focusing on cGMP and VASP phosphorylation. Moreover, this allows to …
BACKGROUND: The cyclic nucleotides cAMP and cGMP inhibit platelet activation. Different platelet signaling modules work together. ... …
Regulation of nitric oxide-sensitive guanylyl cyclase.
Friebe A, Koesling D. Friebe A, et al. Circ Res. 2003 Jul 25;93(2):96-105. doi: 10.1161/01.RES.0000082524.34487.31. Circ Res. 2003. PMID: 12881475 Review.
In this review, we outline the current knowledge on the regulation of nitric oxide (NO)-sensitive guanylyl cyclase (GC). Besides NO, the physiological activator that binds to the prosthetic heme group of the enzyme, two novel classes of GC activators have been ident …
In this review, we outline the current knowledge on the regulation of nitric oxide (NO)-sensitive guanylyl cyclase (GC). Besid …
NO-sensitive guanylyl cyclase and NO-induced feedback inhibition in cGMP signaling.
Mullershausen F, Koesling D, Friebe A. Mullershausen F, et al. Among authors: friebe a. Front Biosci. 2005 May 1;10:1269-78. doi: 10.2741/1617. Front Biosci. 2005. PMID: 15769623 Review.
Most effects of the signaling molecule nitric oxide (NO) are mediated by the stimulation of NO-sensitive guanylyl cyclase (GC) and the subsequent intracellular increase in cGMP. ...Sustained activation of PDE5 by cGMP has been identified as the mechani …
Most effects of the signaling molecule nitric oxide (NO) are mediated by the stimulation of NO-sensitive guanylyl cyclase (GC) …
Optical control of a receptor-linked guanylyl cyclase using a photoswitchable peptidic hormone.
Podewin T, Broichhagen J, Frost C, Groneberg D, Ast J, Meyer-Berg H, Fine NHF, Friebe A, Zacharias M, Hodson DJ, Trauner D, Hoffmann-Röder A. Podewin T, et al. Among authors: friebe a. Chem Sci. 2017 Jun 1;8(6):4644-4653. doi: 10.1039/c6sc05044a. Epub 2017 Apr 19. Chem Sci. 2017. PMID: 28626572 Free PMC article.
The endogeneous hormone ANP signals via the natriuretic peptide receptor A (NPR-A) through raising intracellular cGMP concentrations, and is involved in blood pressure regulation and sodium homeostasis, as well as lipid metabolism and pancreatic function. ...Thus, applicat …
The endogeneous hormone ANP signals via the natriuretic peptide receptor A (NPR-A) through raising intracellular cGMP concentrations, …
93 results