Uric acid activates aldose reductase and the polyol pathway for endogenous fructose and fat production causing development of fatty liver in rats.
J Biol Chem. 2019.
PMID: 30651350
Free PMC article.
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Endogenous fructose production: what do we know and how relevant is it?
Curr Opin Clin Nutr Metab Care. 2019 Jul;22(4):289-294. doi: 10.1097/MCO.0000000000000573.
Curr Opin Clin Nutr Metab Care. 2019.
PMID: 31166222
Free PMC article.
Review.
However, besides its dietary source, fructose can be endogenously produced in the body from glucose via the activation of the polyol pathway. In this review, we aim to describe the most recent findings and current knowledge on the potential role of …
However, besides its dietary source, fructose can be endogenously produced in the body from glucose via the activation of the …
Recent Progress on Fructose Metabolism-Chrebp, Fructolysis, and Polyol Pathway.
Nutrients. 2023 Apr 5;15(7):1778. doi: 10.3390/nu15071778.
Nutrients. 2023.
PMID: 37049617
Free PMC article.
Review.
Glut5 knockout mice exhibit poor fructose absorption. In addition, endogenous fructose production via the polyol pathway has also received attention; gene deletion of aldose reductase (Ar), ketohexokinase (Khk), and triokinase (Tkfc) has …
Glut5 knockout mice exhibit poor fructose absorption. In addition, endogenous fructose production via the pol …
Uric acid activates aldose reductase and the polyol pathway for endogenous fructose and fat production causing development of fatty liver in rats.
J Biol Chem. 2019 Mar 15;294(11):4272-4281. doi: 10.1074/jbc.RA118.006158. Epub 2019 Jan 16.
J Biol Chem. 2019.
PMID: 30651350
Free PMC article.
Recent studies suggest that fructose also can be produced via the polyol pathway in the liver, where it may induce hepatic fat accumulation. ...These results suggest that uric acid generated during fructose metabolism may act as a positive feedback mec …
Recent studies suggest that fructose also can be produced via the polyol pathway in the liver, where it may induce hepa …
Fructose Metabolism in Cancer.
Cells. 2020 Dec 8;9(12):2635. doi: 10.3390/cells9122635.
Cells. 2020.
PMID: 33302403
Free PMC article.
Review.
In this article, we present an overview of the metabolic pathways that utilize fructose and how fructose metabolism can sustain cancer cell proliferation. ...We describe the different metabolic fates of fructose carbons and how they are connected to li …
In this article, we present an overview of the metabolic pathways that utilize fructose and how fructose metabolism can …
Endogenous Fructose Production and Metabolism Drive Metabolic Dysregulation and Liver Disease in Mice with Hereditary Fructose Intolerance.
Nutrients. 2023 Oct 16;15(20):4376. doi: 10.3390/nu15204376.
Nutrients. 2023.
PMID: 37892451
Free PMC article.
However, clinical symptoms still occur, suggesting that either low amounts of fructose are still being consumed or, alternatively, fructose is being produced endogenously in the body. ...We show that generically and pharmacologically blocking this pathway …
However, clinical symptoms still occur, suggesting that either low amounts of fructose are still being consumed or, alternatively, …
Aldose reductase, fructose and fat production in the liver.
Biochem J. 2025 Mar 5;482(5):295-307. doi: 10.1042/BCJ20240748.
Biochem J. 2025.
PMID: 40040471
Free PMC article.
Review.
However, there has also been the recognition that fructose can be produced directly from intracellular glucose via the evolutionarily conserved polyol pathway whose access is governed by aldose reductase (AR). The purpose of this article is to review the bioc …
However, there has also been the recognition that fructose can be produced directly from intracellular glucose via the evolutionarily …
AKR1B1-dependent fructose metabolism enhances malignancy of cancer cells.
Cell Death Differ. 2024 Dec;31(12):1611-1624. doi: 10.1038/s41418-024-01393-4. Epub 2024 Oct 15.
Cell Death Differ. 2024.
PMID: 39406918
Free PMC article.
In this study, we demonstrate that cancer cells can convert glucose into fructose through a process called the AKR1B1-mediated polyol pathway. Inhibiting the endogenous production of fructose through AKR1B1 deletion dramatically suppresse …
In this study, we demonstrate that cancer cells can convert glucose into fructose through a process called the AKR1B1-mediated pol …
The fructose survival hypothesis for obesity.
Philos Trans R Soc Lond B Biol Sci. 2023 Sep 11;378(1885):20220230. doi: 10.1098/rstb.2022.0230. Epub 2023 Jul 24.
Philos Trans R Soc Lond B Biol Sci. 2023.
PMID: 37482773
Free PMC article.
Review.
The process is initiated by the ingestion of fructose or by stimulating endogenous fructose production via the polyol pathway. Unlike other nutrients, fructose reduces the active energy (adenosine triphosphate) in the cell, while b …
The process is initiated by the ingestion of fructose or by stimulating endogenous fructose production via the …
Endogenous fructose production and fructokinase activation mediate renal injury in diabetic nephropathy.
J Am Soc Nephrol. 2014 Nov;25(11):2526-38. doi: 10.1681/ASN.2013080901. Epub 2014 May 29.
J Am Soc Nephrol. 2014.
PMID: 24876114
Free PMC article.
We and others recently identified a potential deleterious role of dietary fructose in the generation of tubulointerstitial injury and the acceleration of CKD. In this study, we investigated the potential role of endogenous fructose production, as oppos …
We and others recently identified a potential deleterious role of dietary fructose in the generation of tubulointerstitial injury and …
Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome.
Nat Commun. 2013;4:2434. doi: 10.1038/ncomms3434.
Nat Commun. 2013.
PMID: 24022321
Free PMC article.
High serum glucose concentrations are known to induce the polyol pathway and increase fructose generation in the liver. Here we show that this hepatic, endogenously produced fructose causes systemic metabolic changes. ...We conclude that endo …
High serum glucose concentrations are known to induce the polyol pathway and increase fructose generation in the liver. …
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