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145 results

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Page 1
Neutrophils and NETs in modulating acute and chronic inflammation.
Castanheira FVS, Kubes P. Castanheira FVS, et al. Blood. 2019 May 16;133(20):2178-2185. doi: 10.1182/blood-2018-11-844530. Epub 2019 Mar 21. Blood. 2019. PMID: 30898862 Free article. Review.
Neutrophils are able to counteract an infection through phagocytosis and/or the release of neutrophil extracellular traps (NETs). By contrast, neutrophils help repair damaged tissues, limiting NET production but still phagocytosing debris. However, when inflammation …
Neutrophils are able to counteract an infection through phagocytosis and/or the release of neutrophil extracellular traps (NETs). By …
Endometriosis.
Garner CH, Webster BW. Garner CH, et al. J Obstet Gynecol Neonatal Nurs. 1985 Nov-Dec;14(6 Suppl):10s-20s. doi: 10.1111/j.1552-6909.1985.tb02795.x. J Obstet Gynecol Neonatal Nurs. 1985. PMID: 2934522 Review.
The etiology and physiology are poorly understood, often frustrating clinicians and patient. Treatment may be medical or surgical, or a combination of these. ...
The etiology and physiology are poorly understood, often frustrating clinicians and patient. Treatment may be medical or surgical, or …
Direct Observations of Silver Nanowire-Induced Frustrated Phagocytosis among NR8383 Lung Alveolar Macrophages.
Ogorodnik E, Karsai A, Wang KH, Liu FT, Lo SH, Pinkerton KE, Gilbert B, Haudenschild DR, Liu GY. Ogorodnik E, et al. J Phys Chem B. 2020 Dec 24;124(51):11584-11592. doi: 10.1021/acs.jpcb.0c08132. Epub 2020 Dec 11. J Phys Chem B. 2020. PMID: 33306381 Free PMC article.
While frustrated phagocytosis is known for long microwires and long carbon nanotubes, this work reports first direct observations of frustrated phagocytosis of AgNWs among living cells in situ. In the case of partial penetration of AgNWs into NR8383 ce …
While frustrated phagocytosis is known for long microwires and long carbon nanotubes, this work reports first direct observati …
A phosphoinositide-based model of actin waves in frustrated phagocytosis.
Avila Ponce de León MA, Félix B, Othmer HG. Avila Ponce de León MA, et al. J Theor Biol. 2021 Oct 21;527:110764. doi: 10.1016/j.jtbi.2021.110764. Epub 2021 May 21. J Theor Biol. 2021. PMID: 34029577
Recent experiments have used a confinement technique that leads to a process called frustrated phagocytosis, in which the membrane does not deform, but rather, signaling triggers actin waves that propagate along the boundary of the cell. ...Herein we develop a model …
Recent experiments have used a confinement technique that leads to a process called frustrated phagocytosis, in which the memb …
Ferroptosis-like cell death promotes and prolongs inflammation in Drosophila.
Davidson AJ, Heron R, Das J, Overholtzer M, Wood W. Davidson AJ, et al. Nat Cell Biol. 2024 Sep;26(9):1535-1544. doi: 10.1038/s41556-024-01450-7. Epub 2024 Jun 25. Nat Cell Biol. 2024. PMID: 38918597 Free PMC article.
We further demonstrate that macrophages rapidly engage these necrotic cells within the embryo but struggle to engulf them, leading to prolonged, frustrated phagocytosis and frequent corpse disintegration. Conversely, suppression of the ferroptotic programme during w …
We further demonstrate that macrophages rapidly engage these necrotic cells within the embryo but struggle to engulf them, leading to prolon …
Frustrated phagocytosis on micro-patterned immune complexes to characterize lysosome movements in live macrophages.
Labrousse AM, Meunier E, Record J, Labernadie A, Beduer A, Vieu C, Ben Safta T, Maridonneau-Parini I. Labrousse AM, et al. Front Immunol. 2011 Oct 12;2:51. doi: 10.3389/fimmu.2011.00051. eCollection 2011. Front Immunol. 2011. PMID: 22566841 Free PMC article.
Distances between IC patterns were adapted to optimize cell spreading in order to constrain lysosome movements mostly in two dimensions. Fcgamma receptors triggered local frustrated phagocytosis, frustrated phagosomes appeared as rings of F-actin dots around …
Distances between IC patterns were adapted to optimize cell spreading in order to constrain lysosome movements mostly in two dimensions. Fcg …
Nanosensor detection of reactive oxygen and nitrogen species leakage in frustrated phagocytosis of nanofibres.
Qi YT, Zhang FL, Tian SY, Wu HQ, Zhao Y, Zhang XW, Liu YL, Fu P, Amatore C, Huang WH. Qi YT, et al. Nat Nanotechnol. 2024 Apr;19(4):524-533. doi: 10.1038/s41565-023-01575-0. Epub 2024 Jan 3. Nat Nanotechnol. 2024. PMID: 38172432
Here we report an electrochemical nanosensor that is used to monitor and quantitatively characterize the flux and dynamics of reactive species release during the frustrated phagocytosis of glass nanofibres by single macrophages. We show the existence of an intense p …
Here we report an electrochemical nanosensor that is used to monitor and quantitatively characterize the flux and dynamics of reactive speci …
Microglial advances in Parkinson's disease.
Debasa-Mouce M, Ouro A, De Leon J, Gulkarov S, Reiss AB, Bougea A. Debasa-Mouce M, et al. Adv Immunol. 2026;171:247-281. doi: 10.1016/bs.ai.2026.06.003. Epub 2026 Jun 22. Adv Immunol. 2026. PMID: 42629127 Review.
Their detrimental effects result from direct phagocytosis of dopaminergic neurons as well as via neuroinflammation and release of toxic reactive oxygen and nitrogen species. ...Furthermore, the extreme biophysical stability of aggregated alpha-synuclein overwhelms the micr …
Their detrimental effects result from direct phagocytosis of dopaminergic neurons as well as via neuroinflammation and release of tox …
Observing Frustrated Phagocytosis and Phagosome Formation and Closure Using Total Internal Reflection Fluorescence Microscopy (TIRFM).
Mularski A, Marie-Anaïs F, Mazzolini J, Niedergang F. Mularski A, et al. Methods Mol Biol. 2018;1784:165-175. doi: 10.1007/978-1-4939-7837-3_16. Methods Mol Biol. 2018. PMID: 29761398
Complementary methods to observe frustrated phagocytosis and phagosome closure using total internal reflection fluorescence microscopy (TIRFM) are described here. Frustrated phagocytosis occurs when phagocytic cells are exposed to an opsonized surface …
Complementary methods to observe frustrated phagocytosis and phagosome closure using total internal reflection fluorescence mi …
Actin nano-architecture of phagocytic podosomes.
Herron JC, Hu S, Watanabe T, Nogueira AT, Liu B, Kern ME, Aaron J, Taylor A, Pablo M, Chew TL, Elston TC, Hahn KM. Herron JC, et al. Nat Commun. 2022 Jul 27;13(1):4363. doi: 10.1038/s41467-022-32038-0. Nat Commun. 2022. PMID: 35896550 Free PMC article.
Podosomes are actin-enriched adhesion structures important for multiple cellular processes, including migration, bone remodeling, and phagocytosis. Here, we characterize the structure and organization of phagocytic podosomes using interferometric photoactivated localizatio …
Podosomes are actin-enriched adhesion structures important for multiple cellular processes, including migration, bone remodeling, and pha …
145 results