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Immunomodulatory and Anti-Inflammatory Effects of Fucoidan: A Review.
Apostolova E, Lukova P, Baldzhieva A, Katsarov P, Nikolova M, Iliev I, Peychev L, Trica B, Oancea F, Delattre C, Kokova V. Apostolova E, et al. Polymers (Basel). 2020 Oct 13;12(10):2338. doi: 10.3390/polym12102338. Polymers (Basel). 2020. PMID: 33066186 Free PMC article. Review.
Algae-derived fucoidans are studied intensively during the last years regarding their multiple biological activities and possible therapeutic potential. However, the source, species, molecular weight, composition, and structure of the polysaccharides, as well as the route …
Algae-derived fucoidans are studied intensively during the last years regarding their multiple biological activities and possible the …
Therapies from fucoidan; multifunctional marine polymers.
Fitton JH. Fitton JH. Mar Drugs. 2011;9(10):1731-60. doi: 10.3390/md9101731. Epub 2011 Sep 30. Mar Drugs. 2011. PMID: 22072995 Free PMC article. Review.
The recent data on toxicology and uptake of fucoidan is detailed together with a discussion on the comparative activities of fractions of fucoidan from different sources. ...In recent years, the production of well characterized reproducible fucoidan fractions …
The recent data on toxicology and uptake of fucoidan is detailed together with a discussion on the comparative activities of fraction …
Fucoidan Prevents the Progression of Osteoarthritis in Rats.
Lee DG, Park SY, Chung WS, Park JH, Hwang E, Mavlonov GT, Kim IH, Kim KY, Yi TH. Lee DG, et al. J Med Food. 2015 Sep;18(9):1032-41. doi: 10.1089/jmf.2014.3334. Epub 2015 Jul 21. J Med Food. 2015. PMID: 26197088
Histological analysis revealed that cartilage morphology and cell counts were also normal in the 100 mg/kg fucoidan group. In addition, the 100 mg/kg fucoidan groups exhibited lower serum tumor necrosis factor alpha (TNF-alpha) (30%), interleukin 1 beta (IL-1beta) ( …
Histological analysis revealed that cartilage morphology and cell counts were also normal in the 100 mg/kg fucoidan group. In additio …
Low-Molecular-Weight Fucoidan Inhibits the Viability and Invasiveness and Triggers Apoptosis in IL-1beta-Treated Human Rheumatoid Arthritis Fibroblast Synoviocytes.
Shu Z, Shi X, Nie D, Guan B. Shu Z, et al. Inflammation. 2015 Oct;38(5):1777-86. doi: 10.1007/s10753-015-0155-8. Inflammation. 2015. PMID: 25787883
Fucoidan is a sulfated polysaccharide found mainly in various species of brown algae and brown seaweed. ...LMW fucoidan may have therapeutic potential in the treatment of rheumatoid arthritis....
Fucoidan is a sulfated polysaccharide found mainly in various species of brown algae and brown seaweed. ...LMW fucoidan may ha
Fucoidan Prevents RANKL-Stimulated Osteoclastogenesis and LPS-Induced Inflammatory Bone Loss via Regulation of Akt/GSK3beta/PTEN/NFATc1 Signaling Pathway and Calcineurin Activity.
Lu SH, Hsia YJ, Shih KC, Chou TC. Lu SH, et al. Mar Drugs. 2019 Jun 10;17(6):345. doi: 10.3390/md17060345. Mar Drugs. 2019. PMID: 31185702 Free PMC article.
However, fucoidan-mediated NFATc1 inactivation was greatly reversed by kenpaullone, a GSK3beta inhibitor. ...These findings suggest that fucoidan may be a potential agent for the treatment of osteoclast-related bone diseases....
However, fucoidan-mediated NFATc1 inactivation was greatly reversed by kenpaullone, a GSK3beta inhibitor. ...These findings suggest t …
Fucoidan elevates surface organic cation transporter 2 expression via upregulation of protein kinase A in uric acid nephropathy.
Wu X, Yan M, Liu T, Liao J, Zhang J, Chen S, Deng W, Zhang S, Sun B, Zhou H, Ke B. Wu X, et al. Exp Ther Med. 2017 Nov;14(5):4153-4159. doi: 10.3892/etm.2017.5077. Epub 2017 Aug 30. Exp Ther Med. 2017. PMID: 29104632 Free PMC article.
Uric acid nephropathy (UAN) is caused by excessive uric acid, and is a key risk factor for uric acid nephrolithiasis, gouty arthritis, renal diseases and cardiovascular diseases. The present study aimed to evaluate the protective effect of fucoidan, a sulfated polys …
Uric acid nephropathy (UAN) is caused by excessive uric acid, and is a key risk factor for uric acid nephrolithiasis, gouty arthritis
Development of Injectable Fucoidan and Biological Macromolecules Hybrid Hydrogels for Intra-Articular Delivery of Platelet-Rich Plasma.
Lu HT, Chang WT, Tsai ML, Chen CH, Chen WY, Mi FL. Lu HT, et al. Mar Drugs. 2019 Apr 19;17(4):236. doi: 10.3390/md17040236. Mar Drugs. 2019. PMID: 31010247 Free PMC article.
However, the major drawbacks of direct PRP injection are unstable biological fixation and fast or burst release of growth factors. Fucoidan is a heparinoid compound that can bind growth factors to control their release rate. Furthermore, fucoidan can reduce arthr
However, the major drawbacks of direct PRP injection are unstable biological fixation and fast or burst release of growth factors. Fucoid
Effect of Fucoidan on Anterior Cruciate Ligament Transection and Medial Meniscectomy Induced Osteoarthritis in High-Fat Diet-Induced Obese Rats.
Sudirman S, Ong AD, Chang HW, Kong ZL. Sudirman S, et al. Nutrients. 2018 May 28;10(6):686. doi: 10.3390/nu10060686. Nutrients. 2018. PMID: 29843440 Free PMC article.
Pharmacological and non-pharmacological treatments can be used for OA. Fucoidan possesses several bioactivities such as antitumor, antiviral, anticoagulation, anti-obesity, and immunomodulation. ...In addition, the weight-bearing tests showed an improvement in the fucoi
Pharmacological and non-pharmacological treatments can be used for OA. Fucoidan possesses several bioactivities such as antitumor, an …
Intra-articular injection of anti-inflammatory peptide-loaded glycol chitosan/fucoidan nanogels to inhibit inflammation and attenuate osteoarthritis progression.
Li T, Yang J, Weng C, Liu P, Huang Y, Meng S, Li R, Yang L, Chen C, Gong X. Li T, et al. Int J Biol Macromol. 2021 Feb 15;170:469-478. doi: 10.1016/j.ijbiomac.2020.12.158. Epub 2020 Dec 24. Int J Biol Macromol. 2021. PMID: 33359610
Glycol chitosan/fucoidan nanogels loaded with anti-inflammatory peptide KAFAK (GC/Fu@KAFAK NGs) were fabricated based on the electrostatic interaction and genipin cross-linking methods. ...
Glycol chitosan/fucoidan nanogels loaded with anti-inflammatory peptide KAFAK (GC/Fu@KAFAK NGs) were fabricated based on the electros …
The differential effect of high and low molecular weight fucoidans on the severity of collagen-induced arthritis in mice.
Park SB, Chun KR, Kim JK, Suk K, Jung YM, Lee WH. Park SB, et al. Phytother Res. 2010 Sep;24(9):1384-91. doi: 10.1002/ptr.3140. Phytother Res. 2010. PMID: 20812282
Fucoidans have been extensively studied for their various biological activities but the exact role of fucoidans on the inflammatory processes associated with arthritic disease has not been studied. The effect of the treatment of high, medium and low molecular weight
Fucoidans have been extensively studied for their various biological activities but the exact role of fucoidans on the inflamm
29 results