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1999 3
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2010 3
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Potential Beneficial Actions of Fucoidan in Brain and Liver Injury, Disease, and Intoxication-Potential Implication of Sirtuins.
Dimitrova-Shumkovska J, Krstanoski L, Veenman L. Dimitrova-Shumkovska J, et al. Mar Drugs. 2020 May 5;18(5):242. doi: 10.3390/md18050242. Mar Drugs. 2020. PMID: 32380741 Free PMC article. Review.
Another pathway whereby fucoidan exerts neuroprotective capabilities is by interactions with P-selectin on endothelial cells, thereby preventing macrophages from entering the brain proper. ...Thus far, it has been used in large doses for treatment of acute liver inj …
Another pathway whereby fucoidan exerts neuroprotective capabilities is by interactions with P-selectin on endothelial cells, thereby …
Fucoidan: a promising agent for brain injury and neurodegenerative disease intervention.
Wang Y, Wang Q, Han X, Ma Y, Zhang Z, Zhao L, Guan F, Ma S. Wang Y, et al. Food Funct. 2021 May 11;12(9):3820-3830. doi: 10.1039/d0fo03153d. Food Funct. 2021. PMID: 33861265 Review.
Brain injury and neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis are urgent medical problems, which severely threaten the life quality of patients and their carers. ...A growing number of studies
Brain injury and neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral
Curcumin-laden dual-targeting fucoidan/chitosan nanocarriers for inhibiting brain inflammation via intranasal delivery.
Don TM, Chang WJ, Jheng PR, Huang YC, Chuang EY. Don TM, et al. Int J Biol Macromol. 2021 Jun 30;181:835-846. doi: 10.1016/j.ijbiomac.2021.04.045. Epub 2021 Apr 18. Int J Biol Macromol. 2021. PMID: 33857519
Curcumin can reduce the production of brain inflammatory mediators and symptoms of brain diseases. However, a large amount of free curcumin needs to be administered to achieve an effective level in the brain because of its poor water-solubility. ...Through in …
Curcumin can reduce the production of brain inflammatory mediators and symptoms of brain diseases. However, a large amount of …
Fucoidan Extracted from Hijiki Protects Brain Microvessel Endothelial Cells Against Diesel Exhaust Particle Exposure-Induced Disruption.
Choi YS, Eom SY, Kim IS, Ali SF, Kleinman MT, Kim YD, Kim H. Choi YS, et al. J Med Food. 2016 May;19(5):466-71. doi: 10.1089/jmf.2015.3635. J Med Food. 2016. PMID: 27152978
This study was performed to evaluate the protective effects of fucoidan against the decreased function of primary cultured bovine brain microvessel endothelial cells (BBMECs) after exposure to diesel exhaust particles (DEPs). ...The increased oxidative stress in BBM …
This study was performed to evaluate the protective effects of fucoidan against the decreased function of primary cultured bovine …
Fucoidan serves a neuroprotective effect in an Alzheimer's disease model.
Subaraja M, Anantha Krishnan D, Edwin Hillary V, William Raja TR, Mathew P, Ravikumar S, Gabriel Paulraj M, Ignacimuthu S. Subaraja M, et al. Front Biosci (Elite Ed). 2020 Jan 1;12:1-34. doi: 10.2741/E855. Front Biosci (Elite Ed). 2020. PMID: 31585867 Free article.
The present study was carried out to evaluate the protective effects of fucoidan in monocrotophos induced AD in Drosophila melanogaster. In silico studies showed that fucoidan exhibited binding energy of -9.3 kcal with proteins. ...Together, the findings show that …
The present study was carried out to evaluate the protective effects of fucoidan in monocrotophos induced AD in Drosophila melanogast …
Fucoidan Modulated Oxidative Stress and Caspase-3 mRNA Expression Induced by Sulfoxaflor in the Brain of Mice.
Piner Benli P, Kaya M, Coskun C. Piner Benli P, et al. Neurotox Res. 2021 Dec;39(6):1908-1919. doi: 10.1007/s12640-021-00415-0. Epub 2021 Sep 27. Neurotox Res. 2021. PMID: 34570347
The current study aimed to investigate the role of fucoidan in the oxidative and apoptotic effects of sulfoxaflor, a neonicotinoid sulfoximine insecticide, in the brain of Swiss albino mice (Mus musculus). ...Fucoidan treatment modulated all the aforementione …
The current study aimed to investigate the role of fucoidan in the oxidative and apoptotic effects of sulfoxaflor, a neonicotinoid su …
Fucoidan exerts antidepressant-like effects in mice via regulating the stability of surface AMPARs.
Li M, Sun X, Li Q, Li Y, Luo C, Huang H, Chen J, Gong C, Li Y, Zheng Y, Zhang S, Huang X, Chen H. Li M, et al. Biochem Biophys Res Commun. 2020 Jan 8;521(2):318-325. doi: 10.1016/j.bbrc.2019.10.043. Epub 2019 Oct 24. Biochem Biophys Res Commun. 2020. PMID: 31668812
However, the antidepressant effects of fucoidan on chronic stress-induced depressive-like behaviors have not been well elucidated. ...Furthermore, blocking BDNF abolished the antidepressant-like effects of fucoidan in mice. Therefore, our findings clearly indicate t …
However, the antidepressant effects of fucoidan on chronic stress-induced depressive-like behaviors have not been well elucidated. .. …
Fucoidan from Fucus vesiculosus Fails to Improve Outcomes Following Intracerebral Hemorrhage in Mice.
Burchell SR, Iniaghe LO, Zhang JH, Tang J. Burchell SR, et al. Acta Neurochir Suppl. 2016;121:191-8. doi: 10.1007/978-3-319-18497-5_34. Acta Neurochir Suppl. 2016. PMID: 26463947
Animals were randomly divided into the following groups: sham, ICH + vehicle, ICH + 25 mg/kg fucoidan, ICH + 75 mg/kg fucoidan, and ICH + 100 mg/kg fucoidan. Brain water content, neurobehavioral outcomes, and hemoglobin content were evaluated at 24 h p …
Animals were randomly divided into the following groups: sham, ICH + vehicle, ICH + 25 mg/kg fucoidan, ICH + 75 mg/kg fucoidan
Raloxifene as Treatment for Various Types of Brain Injuries and Neurodegenerative Diseases: A Good Start.
Veenman L. Veenman L. Int J Mol Sci. 2020 Oct 14;21(20):7586. doi: 10.3390/ijms21207586. Int J Mol Sci. 2020. PMID: 33066585 Free PMC article. Review.
Recent studies have shown that the selective estrogen receptor modulator (SERM) raloxifene had pronounced protective effects against progressing brain damage after traumatic brain injury (TBI) in mice. These studies, indicating beneficial effects of raloxifene for …
Recent studies have shown that the selective estrogen receptor modulator (SERM) raloxifene had pronounced protective effects against progres …
Fucoidan-Rich Substances from Ecklonia cava Improve Trimethyltin-Induced Cognitive Dysfunction via Down-Regulation of Amyloid beta Production/Tau Hyperphosphorylation.
Park SK, Kang JY, Kim JM, Yoo SK, Han HJ, Chung DH, Kim DO, Kim GH, Heo HJ. Park SK, et al. Mar Drugs. 2019 Oct 17;17(10):591. doi: 10.3390/md17100591. Mar Drugs. 2019. PMID: 31627432 Free PMC article.
Ecklonia cava (E. cava) was investigated to compare the effect of polyphenol and fucoidan extract and mixture (polyphenol:fucoidan = 4:6) on cognitive function. ...After a behavioral test, the inhibitory effect of lipid peroxidation and cholinergic system activity w …
Ecklonia cava (E. cava) was investigated to compare the effect of polyphenol and fucoidan extract and mixture (polyphenol:fucoidan
80 results