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Fucoidan Structure and Its Impact on Glucose Metabolism: Implications for Diabetes and Cancer Therapy.
Mabate B, Daub CD, Malgas S, Edkins AL, Pletschke BI. Mabate B, et al. Mar Drugs. 2021 Jan 11;19(1):30. doi: 10.3390/md19010030. Mar Drugs. 2021. PMID: 33440853 Free PMC article. Review.
However, the elucidation of the fucoidan structure and its biological activity is still vague. In addition, research has suggested that there is a link between diabetes and cancer; however, limited data exist where dual chemotherapeutic efforts are elucidated. ...We …
However, the elucidation of the fucoidan structure and its biological activity is still vague. In addition, research has suggested th …
A Combination Approach in Inhibiting Type 2 Diabetes-Related Enzymes Using Ecklonia radiata Fucoidan and Acarbose.
Mabate B, Daub CD, Malgas S, Edkins AL, Pletschke BI. Mabate B, et al. Pharmaceutics. 2021 Nov 22;13(11):1979. doi: 10.3390/pharmaceutics13111979. Pharmaceutics. 2021. PMID: 34834394 Free PMC article.
Although there are chemotherapeutic efforts in place for Type 2 diabetes mellitus (T2DM), there is a need for novel strategies (including natural products) to manage T2DM. Fucoidan, a sulphated polysaccharide was extracted from Ecklonia radiata. ...
Although there are chemotherapeutic efforts in place for Type 2 diabetes mellitus (T2DM), there is a need for novel strategies …
Fucoidan from Ecklonia maxima is a powerful inhibitor of the diabetes-related enzyme, α-glucosidase.
Daub CD, Mabate B, Malgas S, Pletschke BI. Daub CD, et al. Int J Biol Macromol. 2020 May 15;151:412-420. doi: 10.1016/j.ijbiomac.2020.02.161. Epub 2020 Feb 16. Int J Biol Macromol. 2020. PMID: 32070744
The water extracted E. maxima fucoidan had a low molecular weight of approximately 10 kDa. Structural studies (FT-IR, NMR and XRD) confirmed the structure and integrity of the fucoidan to be similar to previously studied fucoidans in literature. ...Our presen …
The water extracted E. maxima fucoidan had a low molecular weight of approximately 10 kDa. Structural studies (FT-IR, NMR and XRD) co …
A Comprehensive Analysis into the Therapeutic Application of Natural Products as SIRT6 Modulators in Alzheimer's Disease, Aging, Cancer, Inflammation, and Diabetes.
Akter R, Afrose A, Rahman MR, Chowdhury R, Nirzhor SSR, Khan RI, Kabir MT. Akter R, et al. Int J Mol Sci. 2021 Apr 17;22(8):4180. doi: 10.3390/ijms22084180. Int J Mol Sci. 2021. PMID: 33920726 Free PMC article. Review.
Thus, it has emerged as an exciting target of several diseases such as cancer, neurodegenerative diseases, aging, diabetes, metabolic disorder, and heart disease. Recent studies have shown that natural compounds can act as modulators of SIRT6. ...The potential application …
Thus, it has emerged as an exciting target of several diseases such as cancer, neurodegenerative diseases, aging, diabetes, metabolic …
Fucoidan prevent murine autoimmune diabetes via suppression TLR4-signaling pathways, regulation DC/Treg induced immune tolerance and improving gut microecology.
Xue M, Liang H, Ji X, Liu Y, Ge Y, Hou L, Sun T. Xue M, et al. Nutr Metab (Lond). 2019 Dec 16;16:87. doi: 10.1186/s12986-019-0392-1. eCollection 2019. Nutr Metab (Lond). 2019. PMID: 31889967 Free PMC article.
BACKGROUND: This study was to investigate the effect and its possible mechanism of fucoidan on the development of spontaneous autoimmune diabetes in non-obese diabetic (NOD) mice. ...The remaining 12 mice per group were fed until 26 weeks of age to assess the …
BACKGROUND: This study was to investigate the effect and its possible mechanism of fucoidan on the development of spontaneous autoimm …
Oligo-Fucoidan Improves Diabetes-Induced Renal Fibrosis via Activation of Sirt-1, GLP-1R, and Nrf2/HO-1: An In Vitro and In Vivo Study.
Yu WC, Huang RY, Chou TC. Yu WC, et al. Nutrients. 2020 Oct 8;12(10):3068. doi: 10.3390/nu12103068. Nutrients. 2020. PMID: 33049944 Free PMC article.
Fucoidan extracted from brown algae has multiple beneficial functions. In this study, we investigated the effects of low-molecular-weight fucoidan (oligo-FO) on renal fibrosis under in vitro and in vivo diabetic conditions, and its molecular mechanisms. ...
Fucoidan extracted from brown algae has multiple beneficial functions. In this study, we investigated the effects of low-molecular-we …
Structural Dependence of Sulfated Polysaccharide for Diabetes Management: Fucoidan From Undaria pinnatifida Inhibiting α-Glucosidase More Strongly Than α-Amylase and Amyloglucosidase.
Koh HSA, Lu J, Zhou W. Koh HSA, et al. Front Pharmacol. 2020 Jun 5;11:831. doi: 10.3389/fphar.2020.00831. eCollection 2020. Front Pharmacol. 2020. PMID: 32581797 Free PMC article.
Fucoidan refers to a group of sulfated polysaccharide that is commonly obtained from various species of brown seaweed. ...This highlights the potential of fucoidan as an antidiabetic agent in the management and prevention of diabetes mellitus. ...
Fucoidan refers to a group of sulfated polysaccharide that is commonly obtained from various species of brown seaweed. ...This highli …
Metabolic regulation mechanism of fucoidan via intestinal microecology in diseases.
Sun T, Xue M, Yang J, Pei Z, Zhang N, Qin K, Liang H. Sun T, et al. J Sci Food Agric. 2021 Aug 30;101(11):4456-4463. doi: 10.1002/jsfa.11202. Epub 2021 Mar 18. J Sci Food Agric. 2021. PMID: 33682122 Review.
Fucoidan particularly effects tumors, inflammatory bowel disease, diabetes and obesity by repairing intestinal mucosal damage and improving the intestinal microecological environment. It has been proposed that fucoidan could be used as a prebiotic agent for p …
Fucoidan particularly effects tumors, inflammatory bowel disease, diabetes and obesity by repairing intestinal mucosal damage …
Effects of fucoidan on diabetic rat testicular tissue.
Ersoy O, Kizilay G. Ersoy O, et al. Biotech Histochem. 2018;93(4):277-285. doi: 10.1080/10520295.2018.1434679. Epub 2018 Mar 7. Biotech Histochem. 2018. PMID: 29513110
We investigated the possible effects of fucoidan, a potent antioxidant with a regulatory effect on blood glucose homeostasis, on the testicular tissues of rats with experimental diabetes. ...Twenty-four Wistar albino male rats were divided into four groups: group 1, …
We investigated the possible effects of fucoidan, a potent antioxidant with a regulatory effect on blood glucose homeostasis, on the …
Sitagliptin and fucoidan prevent apoptosis and reducing ER stress in diabetic rat testes.
Kizilay G, Ersoy O, Cerkezkayabekir A, Topcu-Tarladacalisir Y. Kizilay G, et al. Andrologia. 2021 Apr;53(3):e13858. doi: 10.1111/and.13858. Epub 2021 Jan 21. Andrologia. 2021. PMID: 33474733
We have very limited information about impact of sitagliptin on male genital system and relationship between sitagliptin/diabetes/ER. Fucoidan can be effective in blood glucose homeostasis. We goal to explain of the effect of sitagliptin and introduce an approach of …
We have very limited information about impact of sitagliptin on male genital system and relationship between sitagliptin/diabetes/ER. …
97 results