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Protective Effects of Fucoidan on Epithelial-Mesenchymal Transition of Retinal Pigment Epithelial Cells and Progression of Proliferative Vitreoretinopathy.
Zhang Y, Zhao D, Yang S, Yao H, Li M, Zhao C, Zhang J, Xu GT, Li H, Wang F. Zhang Y, et al. Cell Physiol Biochem. 2018;46(4):1704-1715. doi: 10.1159/000489246. Epub 2018 Apr 23. Cell Physiol Biochem. 2018. PMID: 29698960 Free article.
Moreover, the upregulation of phosphorylated Smad2/3 induced by TGF-beta1 was suppressed by fucoidan. Fucoidan also inhibited the migration and contraction of RPE cells induced by TGF-beta1. In vivo, fucoidan inhibited the progression of experimental PVR in r …
Moreover, the upregulation of phosphorylated Smad2/3 induced by TGF-beta1 was suppressed by fucoidan. Fucoidan also inhibited …
Doxorubicin-fucoidan-gold nanoparticles composite for dual-chemo-photothermal treatment on eye tumors.
Kim H, Nguyen VP, Manivasagan P, Jung MJ, Kim SW, Oh J, Kang HW. Kim H, et al. Oncotarget. 2017 Dec 9;8(69):113719-113733. doi: 10.18632/oncotarget.23092. eCollection 2017 Dec 26. Oncotarget. 2017. PMID: 29371941 Free PMC article.
The current research demonstrates the feasible biomedical application of AuNPs coated with doxorubicin (Dox)-loaded fucoidan (Fu) for dual-chemotherapy and photothermal treatment (PTT) on eye tumors in vitro and in vivo. ...Therefore, the proposed Dox-Fu@AuNPs can b …
The current research demonstrates the feasible biomedical application of AuNPs coated with doxorubicin (Dox)-loaded fucoidan (Fu) for …
Fucoidan reduces secretion and expression of vascular endothelial growth factor in the retinal pigment epithelium and reduces angiogenesis in vitro.
Dithmer M, Fuchs S, Shi Y, Schmidt H, Richert E, Roider J, Klettner A. Dithmer M, et al. PLoS One. 2014 Feb 18;9(2):e89150. doi: 10.1371/journal.pone.0089150. eCollection 2014. PLoS One. 2014. PMID: 24558482 Free PMC article.
Fucoidan is a polysaccharide isolated from brown algae which is of current interest for anti-tumor therapy. ...Fucoidan decreases VEGF secretion in RPE/choroid explants and RPE cells. ...
Fucoidan is a polysaccharide isolated from brown algae which is of current interest for anti-tumor therapy. ...Fucoidan decrea
Fucoidan protects ARPE-19 cells from oxidative stress via normalization of reactive oxygen species generation through the Ca2+-dependent ERK signaling pathway.
Li X, Zhao H, Wang Q, Liang H, Jiang X. Li X, et al. Mol Med Rep. 2015 May;11(5):3746-52. doi: 10.3892/mmr.2015.3224. Epub 2015 Jan 19. Mol Med Rep. 2015. PMID: 25606812
Therefore, the aim of the present study was to evaluate the role of fucoidan in DR. The human retinal pigment epithelial cell line ARPE-19 was exposed to high D-glucose in the presence or absence of fucoidan. ...Fucoidan also inhibited high glucose-induced ce …
Therefore, the aim of the present study was to evaluate the role of fucoidan in DR. The human retinal pigment epithelial cell line AR …
Fucoidans as Potential Therapeutics for Age-Related Macular Degeneration-Current Evidence from In Vitro Research.
Dörschmann P, Klettner A. Dörschmann P, et al. Int J Mol Sci. 2020 Dec 4;21(23):9272. doi: 10.3390/ijms21239272. Int J Mol Sci. 2020. PMID: 33291752 Free PMC article. Review.
Fucoidans from Saccharina latissima and Laminaria hyperborea were identified as the most promising candidates for further development. Further research is warranted to establish fucoidans as potential therapeutics for AMD....
Fucoidans from Saccharina latissima and Laminaria hyperborea were identified as the most promising candidates for further development
Effects of Crude Fucus distichus Subspecies evanescens Fucoidan Extract on Retinal Pigment Epithelium Cells-Implications for Use in Age-Related Macular Degeneration.
Rohwer K, Neupane S, Bittkau KS, Galarza Pérez M, Dörschmann P, Roider J, Alban S, Klettner A. Rohwer K, et al. Mar Drugs. 2019 Sep 16;17(9):538. doi: 10.3390/md17090538. Mar Drugs. 2019. PMID: 31527536 Free PMC article.
Fucoidan extracts may have beneficial effects in age-related macular degeneration(AMD). Over-the-counter fucoidan preparations are generally undefined, crude extracts. In thisstudy, we investigated the effect of a crude fucoidan extract from Fucus distichus s
Fucoidan extracts may have beneficial effects in age-related macular degeneration(AMD). Over-the-counter fucoidan preparations
Evaluation of a Brown Seaweed Extract from Dictyosiphon foeniculaceus as a Potential Therapeutic Agent for the Treatment of Glioblastoma and Uveal Melanoma.
Dörschmann P, Schmitt C, Bittkau KS, Neupane S, Synowitz M, Roider J, Alban S, Held-Feindt J, Klettner A. Dörschmann P, et al. Mar Drugs. 2020 Dec 8;18(12):625. doi: 10.3390/md18120625. Mar Drugs. 2020. PMID: 33302412 Free PMC article.
Ingredients of brown seaweed like fucoidans are often described for their beneficial biological effects, that might be interesting for a medical application. ...The results in glioblastoma were not promising, but the anti-tumor properties in OMM-1 could make them interesti …
Ingredients of brown seaweed like fucoidans are often described for their beneficial biological effects, that might be interesting fo …
Attenuation of streptozotocin-induced diabetic retinopathy with low molecular weight fucoidan via inhibition of vascular endothelial growth factor.
Yang W, Yu X, Zhang Q, Lu Q, Wang J, Cui W, Zheng Y, Wang X, Luo D. Yang W, et al. Exp Eye Res. 2013 Oct;115:96-105. doi: 10.1016/j.exer.2013.06.011. Epub 2013 Jun 28. Exp Eye Res. 2013. PMID: 23810809
It is a leading cause of blindness in many countries, yet efficient drugs are limited now for prevention and treatment of DR. Low molecular weight fucoidan (LMWF), extract from brown algae, has been shown to possess multiple biological activities like anti-inflammation, an …
It is a leading cause of blindness in many countries, yet efficient drugs are limited now for prevention and treatment of DR. Low molecular …
Effects of a Newly Developed Enzyme-Assisted Extraction Method on the Biological Activities of Fucoidans in Ocular Cells.
Dörschmann P, Mikkelsen MD, Thi TN, Roider J, Meyer AS, Klettner A. Dörschmann P, et al. Mar Drugs. 2020 May 26;18(6):282. doi: 10.3390/md18060282. Mar Drugs. 2020. PMID: 32466624 Free PMC article.
For this study crude fucoidans were extracted from seaweeds using different enzymes and SL fucoidans were further separated into three fractions (SL_F1-F3) by ion-exchange chromatography (IEX). ...Secreted VEGF was analyzed via ELISA (enzyme-linked immunosorbent ass …
For this study crude fucoidans were extracted from seaweeds using different enzymes and SL fucoidans were further separated in …
Effects of Fucoidans from Five Different Brown Algae on Oxidative Stress and VEGF Interference in Ocular Cells.
Dörschmann P, Bittkau KS, Neupane S, Roider J, Alban S, Klettner A. Dörschmann P, et al. Mar Drugs. 2019 Apr 30;17(5):258. doi: 10.3390/md17050258. Mar Drugs. 2019. PMID: 31052228 Free PMC article.
Affinity to VEGF was determined by a competitive binding assay. RESULTS: All fucoidans protected OMM-1 from oxidative stress. However, in ARPE19, only fucoidan from Saccharina latissima was protective. ...In primary RPE, only the fucoidan from Saccharina lati …
Affinity to VEGF was determined by a competitive binding assay. RESULTS: All fucoidans protected OMM-1 from oxidative stress. However …
14 results