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1998 1
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Page 1
Positron Emission Tomography and Autoradiography Imaging of P-selectin Activation Using 68Ga-Fucoidan in Photothrombotic Stroke.
Israel I, Fluri F, Schadt F, Buck AK, Samnick S. Israel I, et al. Curr Neurovasc Res. 2018;15(1):55-62. doi: 10.2174/1567202615666180319152007. Curr Neurovasc Res. 2018. PMID: 29557745
The latter is crucial for therapeutic decision-making of wake-up strokes (i.e. thrombolysis or not). Here, we evaluated the specific p-selectin inhibitor fucoidan labeled with gallium-68 (68Ga-Fucoidan) as an imaging biomarker for assessing p-selectin activat …
The latter is crucial for therapeutic decision-making of wake-up strokes (i.e. thrombolysis or not). Here, we evaluated the specific …
Fucoidan-functionalized polysaccharide submicroparticles loaded with alteplase for efficient targeted thrombolytic therapy.
Zenych A, Jacqmarcq C, Aid R, Fournier L, Forero Ramirez LM, Chaubet F, Bonnard T, Vivien D, Letourneur D, Chauvierre C. Zenych A, et al. Biomaterials. 2021 Oct;277:121102. doi: 10.1016/j.biomaterials.2021.121102. Epub 2021 Aug 30. Biomaterials. 2021. PMID: 34482087
The experiments on the murine model of acute thromboembolic ischemic stroke support this product's therapeutic efficacy, revealing a faster recanalization rate in the middle cerebral artery than with free alteplase, which reduces post-ischemic cerebral infarct lesio …
The experiments on the murine model of acute thromboembolic ischemic stroke support this product's therapeutic efficacy, revea …
Fucoidan from Fucus vesiculosus Fails to Improve Outcomes Following Intracerebral Hemorrhage in Mice.
Burchell SR, Iniaghe LO, Zhang JH, Tang J. Burchell SR, et al. Acta Neurochir Suppl. 2016;121:191-8. doi: 10.1007/978-3-319-18497-5_34. Acta Neurochir Suppl. 2016. PMID: 26463947
Finally, we found that fucoidan had no effect on the hemoglobin content after ICH. We postulate that fucoidan treatment did not improve the measured outcomes after ICH because we used crude fucoidan, which has a high molecular weight, in our study. High-molec …
Finally, we found that fucoidan had no effect on the hemoglobin content after ICH. We postulate that fucoidan treatment did no …
Amino-Fucoidan as a Vector for rtPA-Induced Fibrinolysis in Experimental Thrombotic Events.
Ghebouli R, Loyau S, Maire M, Saboural P, Collet JP, Jandrot-Perrus M, Letourneur D, Chaubet F, Michel JB. Ghebouli R, et al. Thromb Haemost. 2018 Jan;118(1):42-53. doi: 10.1160/TH17-02-0132. Epub 2018 Jan 5. Thromb Haemost. 2018. PMID: 29304524
Acute ischaemic stroke, myocardial infarction and pulmonary embolism are the main causes of mortality and morbidity worldwide. ...However, this procedure is limited by significant drawbacks, including high doses and bleeding complications. Recent studies showed that fuc …
Acute ischaemic stroke, myocardial infarction and pulmonary embolism are the main causes of mortality and morbidity worldwide. ...How …
Fucoidan from Undaria pinnatifida prevents vascular dysfunction through PI3K/Akt/eNOS-dependent mechanisms in the l-NAME-induced hypertensive rat model.
Li X, Li J, Li Z, Sang Y, Niu Y, Zhang Q, Ding H, Yin S. Li X, et al. Food Funct. 2016 May 18;7(5):2398-408. doi: 10.1039/c6fo00288a. Epub 2016 May 6. Food Funct. 2016. PMID: 27153123
Here, we examined the effect of fucoidan on eNOS activation in human umbilical vein endothelial cells (HUVECs). ...Together, these results support a putative role of fucoidan in hypertension prevention and treatment....
Here, we examined the effect of fucoidan on eNOS activation in human umbilical vein endothelial cells (HUVECs). ...Together, these re …
Sulfated polysaccharide fucoidan ameliorates experimental autoimmune myocarditis in rats.
Tanaka K, Ito M, Kodama M, Tomita M, Kimura S, Hoyano M, Mitsuma W, Hirono S, Hanawa H, Aizawa Y. Tanaka K, et al. J Cardiovasc Pharmacol Ther. 2011 Mar;16(1):79-86. doi: 10.1177/1074248410378751. Epub 2010 Dec 30. J Cardiovasc Pharmacol Ther. 2011. PMID: 21193680
A 21-day infusion of physiological saline or fucoidan was administrated intraperitoneally to the rats with sham operation (sham-saline, n = 5; sham-fucoidan, n = 6) or those with cardiac myosin injection (EAM-saline, n = 10; EAM-fucoidan, n = 10). ...Fucoi …
A 21-day infusion of physiological saline or fucoidan was administrated intraperitoneally to the rats with sham operation (sham-salin …
Effect of fucoidan treatment on collagenase-induced intracerebral hemorrhage in rats.
Del Bigio MR, Yan HJ, Campbell TM, Peeling J. Del Bigio MR, et al. Neurol Res. 1999 Jun;21(4):415-9. doi: 10.1080/01616412.1999.11740953. Neurol Res. 1999. PMID: 10406016
Inflammatory cells are postulated to mediate some of the brain damage following ischemic stroke. Intracerebral hemorrhage is associated with more inflammation than ischemic stroke. ...Rats were treated with seven day intravenous infusion of fucoidan (30 micro …
Inflammatory cells are postulated to mediate some of the brain damage following ischemic stroke. Intracerebral hemorrhage is associat …
Raloxifene as Treatment for Various Types of Brain Injuries and Neurodegenerative Diseases: A Good Start.
Veenman L. Veenman L. Int J Mol Sci. 2020 Oct 14;21(20):7586. doi: 10.3390/ijms21207586. Int J Mol Sci. 2020. PMID: 33066585 Free PMC article. Review.
At whole central nervous system (CNS) levels, raloxifene ameliorated mild cognitive impairments, as seen in clinical trials, and showed beneficial effects in animal models of Parkinson's disease. Moreover, with stroke and TBI in animal models, raloxifene showed cura …
At whole central nervous system (CNS) levels, raloxifene ameliorated mild cognitive impairments, as seen in clinical trials, and showed bene …
Leukocyte-platelet aggregates in rat peripheral blood after ischemic stroke and reperfusion.
Ritter LS, Stempel KM, Coull BM, McDonagh PF. Ritter LS, et al. Biol Res Nurs. 2005 Apr;6(4):281-8. doi: 10.1177/1099800405274579. Biol Res Nurs. 2005. PMID: 15788737
Ischemic stroke and reperfusion (ISR) is associated with an inflammatory response characterized, in part, by the formation of leukocyte-platelet aggregates (LPA). ...LPA formation may be a useful biomarker and potential therapeutic target after ischemic stroke and r …
Ischemic stroke and reperfusion (ISR) is associated with an inflammatory response characterized, in part, by the formation of leukocy …
Protective effects of inhibiting both blood and vascular selectins after stroke and reperfusion.
Ruehl ML, Orozco JA, Stoker MB, McDonagh PF, Coull BM, Ritter LS. Ruehl ML, et al. Neurol Res. 2002 Apr;24(3):226-32. doi: 10.1179/016164102101199738. Neurol Res. 2002. PMID: 11958413
Early intervention after acute ischemic stroke is essential to minimize brain cell injury. Although reperfusion of the ischemic brain is the treatment of choice for acute stroke, reperfusion itself may cause additional injury. ...These results indicate that treatmen …
Early intervention after acute ischemic stroke is essential to minimize brain cell injury. Although reperfusion of the ischemic brain …
16 results