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Fucoidan from seaweed Fucus vesiculosus inhibits 2,4-dinitrochlorobenzene-induced atopic dermatitis.
Tian T, Chang H, He K, Ni Y, Li C, Hou M, Chen L, Xu Z, Chen B, Ji M. Tian T, et al. Int Immunopharmacol. 2019 Oct;75:105823. doi: 10.1016/j.intimp.2019.105823. Epub 2019 Aug 15. Int Immunopharmacol. 2019. PMID: 31422184
However, the effects of fucoidan on atopic dermatitis (AD) have not been elucidated. To assess this, 2,4-dinitrofluorobenzene (DNFB)-treated BALB/c mice were painted with fucoidan. ...In addition, fucoidan significantly suppressed the serum levels of IgE and ā€¦
However, the effects of fucoidan on atopic dermatitis (AD) have not been elucidated. To assess this, 2,4-dinitrofluorobenzene (DNFB)- ā€¦
Oral Administration of Fucoidan Can Exert Anti-Allergic Activity after Allergen Sensitization by Enhancement of Galectin-9 Secretion in Blood.
Mizuno M, Sakaguchi K, Sakane I. Mizuno M, et al. Biomolecules. 2020 Feb 9;10(2):258. doi: 10.3390/biom10020258. Biomolecules. 2020. PMID: 32050429 Free PMC article.
A previous study revealed that fucoidan inhibited mast cell degranulation through the upregulation of galectin-9 in blood. ...Fucoidan increased galectin-9 mRNA expression only in colonic epithelial cells. ...
A previous study revealed that fucoidan inhibited mast cell degranulation through the upregulation of galectin-9 in blood. ...Fuco ā€¦
F-fucoidan from Saccharina japonica is a novel inducer of galectin-9 and exhibits anti-allergic activity.
Tanino Y, Hashimoto T, Ojima T, Mizuno M. Tanino Y, et al. J Clin Biochem Nutr. 2016 Jul;59(1):25-30. doi: 10.3164/jcbn.15-144. Epub 2016 May 21. J Clin Biochem Nutr. 2016. PMID: 27499575 Free PMC article.
Oral treatment with F-fucoidan suppressed allergic symptoms through the induction of galectin-9. This is the first report that F-fucoidan can induce the secretion of galectin-9....
Oral treatment with F-fucoidan suppressed allergic symptoms through the induction of galectin-9. This is the first report that F-f ā€¦
Fucoidan suppresses IgE production in peripheral blood mononuclear cells from patients with atopic dermatitis.
Iwamoto K, Hiragun T, Takahagi S, Yanase Y, Morioke S, Mihara S, Kameyoshi Y, Hide M. Iwamoto K, et al. Arch Dermatol Res. 2011 Aug;303(6):425-31. doi: 10.1007/s00403-010-1115-7. Epub 2010 Dec 30. Arch Dermatol Res. 2011. PMID: 21191796
In this study, we examined the effect of fucoidan on IgE production in human peripheral blood mononuclear cells (PBMC) in vitro. ...The inhibitory effects of fucoidan were similarly observed for both PBMC from patients with AD and those with healthy donors. ...
In this study, we examined the effect of fucoidan on IgE production in human peripheral blood mononuclear cells (PBMC) in vitro. ...T ā€¦
Topical application of fucoidan improves atopic dermatitis symptoms in NC/Nga mice.
Yang JH. Yang JH. Phytother Res. 2012 Dec;26(12):1898-903. doi: 10.1002/ptr.4658. Epub 2012 Mar 19. Phytother Res. 2012. PMID: 22431003
Three per cent fucoidan or 0.1% dexamethasone was topically applied to the dorsal skin of AD-induced mice for 4 weeks. ...Fucoidan significantly inhibited mRNA expression of these chemokines in a dose-dependent manner. ...
Three per cent fucoidan or 0.1% dexamethasone was topically applied to the dorsal skin of AD-induced mice for 4 weeks. ...Fucoidan ā€¦
The role of algal fucoidans in potential anti-allergic therapeutics.
Vo TS. Vo TS. Int J Biol Macromol. 2020 Dec 15;165(Pt A):1093-1098. doi: 10.1016/j.ijbiomac.2020.09.252. Epub 2020 Oct 5. Int J Biol Macromol. 2020. PMID: 33031853 Review.
Marine environment covers a huge source of extremely potential secondary metabolites for drug discovery. Among them, fucoidans from brown seaweeds have been evidenced to possess various biological activities and health benefit effects. Notably, a great deal of interest has ā€¦
Marine environment covers a huge source of extremely potential secondary metabolites for drug discovery. Among them, fucoidans from b ā€¦
The Oligo Fucoidan Inhibits Platelet-Derived Growth Factor-Stimulated Proliferation of Airway Smooth Muscle Cells.
Yang CH, Tsao CF, Ko WS, Chiou YL. Yang CH, et al. Mar Drugs. 2016 Jan 9;14(1):15. doi: 10.3390/md14010015. Mar Drugs. 2016. PMID: 26761017 Free PMC article.
Further, oligo-fucoidan supplementation reduced PDGF-stimulated extracellular signal-regulated kinase (ERK1/2), Akt, and nuclear factor (NF)-kappaB phosphorylation. Taken together, oligo-fucoidan supplementation might reduce proliferation of PDGF-treated ASMCs throu ā€¦
Further, oligo-fucoidan supplementation reduced PDGF-stimulated extracellular signal-regulated kinase (ERK1/2), Akt, and nuclear fact ā€¦
Suppression of Th2 immune responses by mekabu fucoidan from Undaria pinnatifida sporophylls.
Maruyama H, Tamauchi H, Hashimoto M, Nakano T. Maruyama H, et al. Int Arch Allergy Immunol. 2005 Aug;137(4):289-94. doi: 10.1159/000086422. Epub 2005 Jun 17. Int Arch Allergy Immunol. 2005. PMID: 15970637
BACKGROUND: We demonstrated that mekabu fucoidan obtained from Undaria pinnatifida (Up) sporophylls augments the type 1 T-helper (Th1) cell response in normal BALB/c mice. ...CONCLUSIONS: The pulmonary inflammation was relieved by mekabu fucoidan, which also downreg ā€¦
BACKGROUND: We demonstrated that mekabu fucoidan obtained from Undaria pinnatifida (Up) sporophylls augments the type 1 T-helper (Th1 ā€¦
Marine-derived polysaccharides for regulation of allergic responses.
Vo TS, Kim SK. Vo TS, et al. Adv Food Nutr Res. 2014;73:1-13. doi: 10.1016/B978-0-12-800268-1.00001-9. Adv Food Nutr Res. 2014. PMID: 25300539 Review.
Recently, several marine polysaccharides such alginate, porphyran, fucoidan, and chitin and its derivatives have been found as modulators of allergic responses due to enhancing innate immune system, altering Th1/Th2 balance, inhibiting IgE production, and suppressing mast ā€¦
Recently, several marine polysaccharides such alginate, porphyran, fucoidan, and chitin and its derivatives have been found as modula ā€¦
Organic dust-induced lung injury and repair: Bi-directional regulation by TNFĪ± and IL-10.
Wyatt TA, Nemecek M, Chandra D, DeVasure JM, Nelson AJ, Romberger DJ, Poole JA. Wyatt TA, et al. J Immunotoxicol. 2020 Dec;17(1):153-162. doi: 10.1080/1547691X.2020.1776428. J Immunotoxicol. 2020. PMID: 32634062
Primary peritoneal macrophages (PM) and murine alveolar macrophages (MH-S cells) were treated in vitro with HDE, SRA ligand (fucoidan), rIL-10, and/or PKC isoform inhibitors. HDE induced in vivo lung IL-10 in WT, but not SRA KO mice, and similar trends were demonstrated in ā€¦
Primary peritoneal macrophages (PM) and murine alveolar macrophages (MH-S cells) were treated in vitro with HDE, SRA ligand (fucoidan ā€¦
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