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A Comprehensive Analysis into the Therapeutic Application of Natural Products as SIRT6 Modulators in Alzheimer's Disease, Aging, Cancer, Inflammation, and Diabetes.
Akter R, Afrose A, Rahman MR, Chowdhury R, Nirzhor SSR, Khan RI, Kabir MT. Akter R, et al. Int J Mol Sci. 2021 Apr 17;22(8):4180. doi: 10.3390/ijms22084180. Int J Mol Sci. 2021. PMID: 33920726 Free PMC article. Review.
It plays a crucial role in different molecular pathways linked to DNA repair, tumorigenesis, glycolysis, gluconeogenesis, neurodegeneration, cardiac hypertrophic responses, etc. Thus, it has emerged as an exciting target of several diseases such as cancer, neurodegenerativ …
It plays a crucial role in different molecular pathways linked to DNA repair, tumorigenesis, glycolysis, gluconeogenesis, neurodegeneration, …
The Potential of Dietary Bioactive Compounds against SARS-CoV-2 and COVID-19-Induced Endothelial Dysfunction.
Losso JN. Losso JN. Molecules. 2022 Mar 1;27(5):1623. doi: 10.3390/molecules27051623. Molecules. 2022. PMID: 35268723 Free PMC article. Review.
COVID-19 is an endothelial disease. All the major comorbidities that increase the risk for severe SARS-CoV-2 infection and severe COVID-19 including old age, obesity, diabetes, hypertension, respiratory disease, compromised immune system, coronary artery disease …
COVID-19 is an endothelial disease. All the major comorbidities that increase the risk for severe SARS-CoV-2 infection and severe COV …
A comprehensive review on polysaccharides with hypolipidemic activity: Occurrence, chemistry and molecular mechanism.
Kalita P, Ahmed AB, Sen S, Chakraborty R. Kalita P, et al. Int J Biol Macromol. 2022 May 1;206:681-698. doi: 10.1016/j.ijbiomac.2022.02.189. Epub 2022 Mar 3. Int J Biol Macromol. 2022. PMID: 35247430 Review.
Different mushroom, plant, fungus, algae, vegetables, microalgae etc. are some important source of several polysaccharide macromolecules such as glucans, ulvan A, ulvan B, fucoidan, rhamnan sulfate, laminarin sulfate, agar, alginate, heteroglycans. ...Dyslipidemia is a ser …
Different mushroom, plant, fungus, algae, vegetables, microalgae etc. are some important source of several polysaccharide macromolecules suc …
Fucoidan Protects against Doxorubicin-Induced Cardiotoxicity by Reducing Oxidative Stress and Preventing Mitochondrial Function Injury.
Ji Y, Jin D, Qi J, Wang X, Zhang C, An P, Luo Y, Luo J. Ji Y, et al. Int J Mol Sci. 2022 Sep 14;23(18):10685. doi: 10.3390/ijms231810685. Int J Mol Sci. 2022. PMID: 36142635 Free PMC article.
In addition, fucoidan also increased the ATP production capacity and restored the levels of a mitochondrial respiratory chain complex in heart tissue. Collectively, this study highlights fucoidan as a potential polysaccharide for protecting against DOXO-induc …
In addition, fucoidan also increased the ATP production capacity and restored the levels of a mitochondrial respiratory chain complex …
Fucoidan inhibits apoptosis and improves cardiac remodeling by inhibiting p53 transcriptional activation through USP22/Sirt 1.
Wang S, Bai J, Che Y, Qu W, Li J. Wang S, et al. Front Pharmacol. 2023 May 30;14:1164333. doi: 10.3389/fphar.2023.1164333. eCollection 2023. Front Pharmacol. 2023. PMID: 37324479 Free PMC article.
Background: Humans with hypertensive heart disease are more likely to experience heart failure, arrhythmia, myocardial infarction, and sudden death, and it is crucial to treat this condition. ...According to this study, FO might be potential targeted approach …
Background: Humans with hypertensive heart disease are more likely to experience heart failure, arrhythmia, myocardial …
Evidence for the Fucoidan/P-Selectin Axis as a Therapeutic Target in Hypoxia-induced Pulmonary Hypertension.
Novoyatleva T, Kojonazarov B, Owczarek A, Veeroju S, Rai N, Henneke I, Böhm M, Grimminger F, Ghofrani HA, Seeger W, Weissmann N, Schermuly RT. Novoyatleva T, et al. Am J Respir Crit Care Med. 2019 Jun 1;199(11):1407-1420. doi: 10.1164/rccm.201806-1170OC. Am J Respir Crit Care Med. 2019. PMID: 30557519
Objectives: We aimed to evaluate the therapeutic potential of targeting the fucoidan/P-selectin axis in PH. Methods: Mice with PH induced by chronic hypoxia (35 d) were given either fucoidan (from Fucus vesiculosus) or anti-P-selectin antibody (Rb40.34) during Days …
Objectives: We aimed to evaluate the therapeutic potential of targeting the fucoidan/P-selectin axis in PH. Methods: Mice with PH ind …
Early Detection of Localized Immunity in Experimental Autoimmune Myocarditis Using [99mTc]Fucoidan SPECT.
Vigne J, Cognet T, Guedj K, Morvan M, Merceron O, Louedec L, Choqueux C, Nicoletti A, Escoubet B, Chaubet F, Michel JB, Rouzet F. Vigne J, et al. Mol Imaging Biol. 2020 Jun;22(3):643-652. doi: 10.1007/s11307-019-01420-8. Mol Imaging Biol. 2020. PMID: 31432389
PURPOSE: The aim of the study was to evaluate the ability of technetium-99m-fucoidan ([(99m)Tc]fucoidan), a molecular imaging agent specific for selectins, in the assessment of early localized immunity in a rat model of experimental autoimmune myocarditis (EAM). ... …
PURPOSE: The aim of the study was to evaluate the ability of technetium-99m-fucoidan ([(99m)Tc]fucoidan), a molecular imaging …
A versatile modification strategy for functional non-glutaraldehyde cross-linked bioprosthetic heart valves with enhanced anticoagulant, anticalcification and endothelialization properties.
Yu T, Pu H, Chen X, Kong Q, Chen C, Li G, Jiang Q, Wang Y. Yu T, et al. Acta Biomater. 2023 Apr 1;160:45-58. doi: 10.1016/j.actbio.2023.02.002. Epub 2023 Feb 9. Acta Biomater. 2023. PMID: 36764592
Valvular heart disease is a major threat to human health and transcatheter heart valve replacement (THVR) has emerged as the primary treatment option for severe heart valve disease. ...STATEMENT OF SIGNIFICANCE: Transcatheter heart valve …
Valvular heart disease is a major threat to human health and transcatheter heart valve replacement (THVR) has emerged a …
Fucoidan reduces inflammatory response in a rat model of hepatic ischemia-reperfusion injury.
Li XJ, Ye QF. Li XJ, et al. Can J Physiol Pharmacol. 2015 Nov;93(11):999-1005. doi: 10.1139/cjpp-2015-0120. Epub 2015 Jun 1. Can J Physiol Pharmacol. 2015. PMID: 26485583
Fucoidan has also shown protective effects on I/R-injured kidney and heart. However, whether fucoidan can attenuate hepatic I/R injury has not been examined. To clarify the role of fucoidan in hepatic I/R injury, Sprague-Dawley rats were subjected to s …
Fucoidan has also shown protective effects on I/R-injured kidney and heart. However, whether fucoidan can attenuate hep …
Fucoidan from Fucus vesiculosus attenuates doxorubicin-induced acute cardiotoxicity by regulating JAK2/STAT3-mediated apoptosis and autophagy.
Zhang J, Sun Z, Lin N, Lu W, Huang X, Weng J, Sun S, Zhang C, Yang Q, Zhou G, Guo H, Chi J. Zhang J, et al. Biomed Pharmacother. 2020 Oct;130:110534. doi: 10.1016/j.biopha.2020.110534. Epub 2020 Jul 22. Biomed Pharmacother. 2020. PMID: 32711244 Free article.
In vitro, H9C2 cells were treated with the same drugs at different concentrations and intervention times. in vivo and in vitro results demonstrated that DOX administration induced myocardial damage accompanied by acceleratory apoptosis and deficient autophagy in heart tiss …
In vitro, H9C2 cells were treated with the same drugs at different concentrations and intervention times. in vivo and in vitro results demon …
40 results