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Antinociceptive effects of fucoidan in rat models of vincristine-induced neuropathic pain.
Hu C, Zhao YT, Zhang G, Xu MF. Hu C, et al. Mol Med Rep. 2017 Feb;15(2):975-980. doi: 10.3892/mmr.2016.6071. Epub 2016 Dec 23. Mol Med Rep. 2017. PMID: 28035379
Chemotherapeutic drugs commonly induce peripheral neuropathic pain, which limit their clinic use. In the present study, the effect of fucoidan on the development of vincristine-induced neuropathic pain was evaluated and the underlying mechanism was examined. …
Chemotherapeutic drugs commonly induce peripheral neuropathic pain, which limit their clinic use. In the present study, the effect of …
Fucoidan attenuates the existing allodynia and hyperalgesia in a rat model of neuropathic pain.
Hu C, Zhang G, Zhao YT. Hu C, et al. Neurosci Lett. 2014 Jun 13;571:66-71. doi: 10.1016/j.neulet.2014.04.030. Epub 2014 May 2. Neurosci Lett. 2014. PMID: 24792391 Free article.
The current study aimed to investigate the effects of fucoidan on the maintenance of neuropathic pain induced by L5 spinal nerve ligation (SNL) and the underlying mechanism related to the spinal neuroimmune responses. ...The analgesic effect of intrathecal fucoid …
The current study aimed to investigate the effects of fucoidan on the maintenance of neuropathic pain induced by L5 spinal ner …
Muscle pain induced by static contraction in rats is modulated by peripheral inflammatory mechanisms.
Santos DFDSD, Melo Aquino B, Jorge CO, Azambuja G, Schiavuzzo JG, Krimon S, Neves JDS, Parada CA, Oliveira-Fusaro MCG. Santos DFDSD, et al. Neuroscience. 2017 Sep 1;358:58-69. doi: 10.1016/j.neuroscience.2017.06.041. Epub 2017 Jun 30. Neuroscience. 2017. PMID: 28673715
Muscle pain is an important health issue and frequently related to static force exertion. The aim of this study is to evaluate whether peripheral inflammatory mechanisms are involved with static contraction-induced muscle pain in rats. To this end, we developed a mo …
Muscle pain is an important health issue and frequently related to static force exertion. The aim of this study is to evaluate whethe …
Antioxidant Properties of Fucoidan Alleviate Acceleration and Exacerbation of Hippocampal Neuronal Death Following Transient Global Cerebral Ischemia in High-Fat Diet-Induced Obese Gerbils.
Ahn JH, Shin MC, Kim DW, Kim H, Song M, Lee TK, Lee JC, Kim H, Cho JH, Kim YM, Kim JD, Choi SY, Won MH, Park JH. Ahn JH, et al. Int J Mol Sci. 2019 Jan 28;20(3):554. doi: 10.3390/ijms20030554. Int J Mol Sci. 2019. PMID: 30696078 Free PMC article.
Fucoidan, a natural sulfated polysaccharide, displays various biological activities including antioxidant properties. ...Gerbils received HFD for 12 weeks and fucoidan (50 mg/kg) daily for the last 5 days during HFD exposure, and they were subjected to 5-min tGCI. . …
Fucoidan, a natural sulfated polysaccharide, displays various biological activities including antioxidant properties. ...Gerbils rece …
The combination of wheat peptides and fucoidan protects against chronic superficial gastritis and alters gut microbiota: a double-blinded, placebo-controlled study.
Kan J, Cheng J, Xu L, Hood M, Zhong D, Cheng M, Liu Y, Chen L, Du J. Kan J, et al. Eur J Nutr. 2020 Jun;59(4):1655-1666. doi: 10.1007/s00394-019-02020-6. Epub 2019 Jun 22. Eur J Nutr. 2020. PMID: 31230147 Clinical Trial.
The aim of this study is to evaluate the protective effect of the combination of wheat peptides and fucoidan (WPF) on adults diagnosed with chronic superficial gastritis in a randomized, double-blind, placebo-controlled clinical trial. ...RESULTS: WPF intervention reduced …
The aim of this study is to evaluate the protective effect of the combination of wheat peptides and fucoidan (WPF) on adults diagnose …
Treatment of murine osteoarthritis with TrkAd5 reveals a pivotal role for nerve growth factor in non-inflammatory joint pain.
McNamee KE, Burleigh A, Gompels LL, Feldmann M, Allen SJ, Williams RO, Dawbarn D, Vincent TL, Inglis JJ. McNamee KE, et al. Pain. 2010 May;149(2):386-392. doi: 10.1016/j.pain.2010.03.002. Epub 2010 Mar 29. Pain. 2010. PMID: 20350782
TrkAd5 was highly effective at suppressing pain in both phases. Induction of NGF in the post-operative phase of pain was TNF-dependent as anti-TNF reduced NGF expression in the joint and abrogated pain. However, TNF was not regulated in the late OA joints, an …
TrkAd5 was highly effective at suppressing pain in both phases. Induction of NGF in the post-operative phase of pain was TNF-d …
Low molecular weight fucoidan ameliorates hindlimb ischemic injury in type 2 diabetic rats.
Wang Z, Liu T, Chen X, You H, Zhang Q, Xue J, Zheng Y, Luo D. Wang Z, et al. J Ethnopharmacol. 2018 Jan 10;210:434-442. doi: 10.1016/j.jep.2017.09.014. Epub 2017 Sep 14. J Ethnopharmacol. 2018. PMID: 28917976
ETHNOPHARMACOLOGICAL RELEVANCE: Low molecular weight fucoidan (LMWF), extracted from Laminaria japonica Areschoug, is a traditional Chinese medicine, commonly used to alleviate edema, particularly for feet with numbness and pain. ...
ETHNOPHARMACOLOGICAL RELEVANCE: Low molecular weight fucoidan (LMWF), extracted from Laminaria japonica Areschoug, is a traditional C …
Effects of fucoidan from Fucus vesiculosus in reducing symptoms of osteoarthritis: a randomized placebo-controlled trial.
Myers SP, Mulder AM, Baker DG, Robinson SR, Rolfe MI, Brooks L, Fitton JH. Myers SP, et al. Biologics. 2016 May 26;10:81-8. doi: 10.2147/BTT.S95165. eCollection 2016. Biologics. 2016. PMID: 27307702 Free PMC article.
PURPOSE: Preliminary investigation of a fucoidan with demonstrated reduction in the symptoms of osteoarthritis (OA) of the hip and knee. ...There were no changes in the blood measurements that were of any clinical significance during the course of the study. CONCLUSION: Th …
PURPOSE: Preliminary investigation of a fucoidan with demonstrated reduction in the symptoms of osteoarthritis (OA) of the hip and kn …
Enhanced Cellular Uptake in an Electrostatically Interacting Fucoidan-L-Arginine Fiber Complex.
Arunagiri V, Tsai HC, Darge HF, Hanurry EY, Lee CY, Lai JY, Wu SY. Arunagiri V, et al. Polymers (Basel). 2021 May 29;13(11):1795. doi: 10.3390/polym13111795. Polymers (Basel). 2021. PMID: 34072354 Free article.
Fucoidan is an abundant marine sulfated polysaccharide extracted from the cell wall of brown macroalgae (seaweed). ...In addition, fucoidan was conjugated with cyanine 3 (Cy3) dye to track its cellular uptake. ...
Fucoidan is an abundant marine sulfated polysaccharide extracted from the cell wall of brown macroalgae (seaweed). ...In addition, …
Selectins and integrins but not platelet-endothelial cell adhesion molecule-1 regulate opioid inhibition of inflammatory pain.
Machelska H, Brack A, Mousa SA, Schopohl JK, Rittner HL, Schäfer M, Stein C. Machelska H, et al. Br J Pharmacol. 2004 Jun;142(4):772-80. doi: 10.1038/sj.bjp.0705837. Epub 2004 May 24. Br J Pharmacol. 2004. PMID: 15159283 Free PMC article.
1. Control of inflammatory pain can result from activation of opioid receptors on peripheral sensory nerves by opioid peptides secreted from leukocytes in response to stress (e.g. experimental swim stress or surgery). ...They point to a cautious use of anti-inflammatory tr …
1. Control of inflammatory pain can result from activation of opioid receptors on peripheral sensory nerves by opioid peptides secret …
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