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Functionally Null RAD51D Missense Mutation Associates Strongly with Ovarian Carcinoma.
Rivera B, Di Iorio M, Frankum J, Nadaf J, Fahiminiya S, Arcand SL, Burk DL, Grapton D, Tomiak E, Hastings V, Hamel N, Wagener R, Aleynikova O, Giroux S, Hamdan FF, Dionne-Laporte A, Zogopoulos G, Rousseau F, Berghuis AM, Provencher D, Rouleau GA, Michaud JL, Mes-Masson AM, Majewski J, Bens S, Siebert R, Narod SA, Akbari MR, Lord CJ, Tonin PN, Orthwein A, Foulkes WD. Rivera B, et al. Cancer Res. 2017 Aug 15;77(16):4517-4529. doi: 10.1158/0008-5472.CAN-17-0190. Epub 2017 Jun 23. Cancer Res. 2017. PMID: 28646019
RAD51D is a key player in DNA repair by homologous recombination (HR), and RAD51D truncating variant carriers have an increased risk for ovarian cancer. ...These results highlight the importance of a functional RAD51D-XRCC2 interaction to promote HR an
RAD51D is a key player in DNA repair by homologous recombination (HR), and RAD51D truncating variant carriers have an increase
Uncoupling of RAD51 focus formation and cell survival after replication fork stalling in RAD51D null CHO cells.
Urbin SS, Elvers I, Hinz JM, Helleday T, Thompson LH. Urbin SS, et al. Environ Mol Mutagen. 2012 Mar;53(2):114-24. doi: 10.1002/em.21672. Epub 2012 Jan 4. Environ Mol Mutagen. 2012. PMID: 22302683
When cells are exposed to agents that arrest DNA replication, such as hydroxyurea or aphidicolin, fork breakage can lead to chromosomal aberrations and cell killing. We assessed the contribution of the HRR protein RAD51D in resistance to killing by replication-associated D …
When cells are exposed to agents that arrest DNA replication, such as hydroxyurea or aphidicolin, fork breakage can lead to chromosomal aber …
Upregulation of mNEIL3 in Ogg1-null cells is a potential backup mechanism for 8-oxoG repair.
Higgs EB, Godschalk R, Langie SAS, van Schooten FJ, Hodges NJ. Higgs EB, et al. Mutagenesis. 2021 Nov 29;36(6):437-444. doi: 10.1093/mutage/geab038. Mutagenesis. 2021. PMID: 34644377
In the current study, we identified components of NER (Ercc1, Ercc4, Ercc5), BER (Lig1, Tdg, Nthl1, Mpg, Mgmt, NEIL3), MMR (Mlh1, Msh2, Msh6) and DSB (Brip1, Rad51d, Prkdc) pathways that are transcriptionally elevated in mOgg1-/- MEFs. Interestingly, all three nucleotide e …
In the current study, we identified components of NER (Ercc1, Ercc4, Ercc5), BER (Lig1, Tdg, Nthl1, Mpg, Mgmt, NEIL3), MMR (Mlh1, Msh2, Msh6 …
RAD51-Mediated DNA Homologous Recombination Is Independent of PTEN Mutational Status.
Sinha A, Saleh A, Endersby R, Yuan SH, Chokshi CR, Brown KR, Kuzio B, Kauppinen T, Singh SK, Baker SJ, McKinnon PJ, Katyal S. Sinha A, et al. Cancers (Basel). 2020 Oct 29;12(11):3178. doi: 10.3390/cancers12113178. Cancers (Basel). 2020. PMID: 33138032 Free PMC article.
Recent studies have linked mutational loss of PTEN to reduced RAD51 expression and function, a key factor involved in the homologous recombination (HR) pathway. ...Cell proliferation studies were used to measure any potential added sensitivity of PTEN-null cells to …
Recent studies have linked mutational loss of PTEN to reduced RAD51 expression and function, a key factor involved in the homologous …
Differential radiosensitivity phenotypes of DNA-PKcs mutations affecting NHEJ and HRR systems following irradiation with gamma-rays or very low fluences of alpha particles.
Lin YF, Nagasawa H, Little JB, Kato TA, Shih HY, Xie XJ, Wilson PF Jr, Brogan JR, Kurimasa A, Chen DJ, Bedford JS, Chen BP. Lin YF, et al. PLoS One. 2014 Apr 8;9(4):e93579. doi: 10.1371/journal.pone.0093579. eCollection 2014. PLoS One. 2014. PMID: 24714417 Free PMC article.
For cells irradiated in late S/G2 phase, mutant cells showed very high yields of chromatid breaks compared to wild-type cells. Few exchanges were seen in DNA-PKcs-null, Ku80-null, or DNA-PKcs kinase dead mutants, but exchanges in excess were detected in the S2506 or …
For cells irradiated in late S/G2 phase, mutant cells showed very high yields of chromatid breaks compared to wild-type cells. Few exchanges …
X-ray irradiation altered chemosensitivity of a p53-null non-small cell lung cancer cell line.
Tsutsumi K, Yasuda M, Nishioka T. Tsutsumi K, et al. Cell Struct Funct. 2006;31(2):47-52. doi: 10.1247/csf.31.47. Cell Struct Funct. 2006. PMID: 16951535 Free article.
In the present study, we first established a cell population from H1299, the p53-null non-small cell lung cancer cell line, by 10 Gy irradiation using 6 MV X-rays. ...These results indicated that some p53-null non-small cell lung cancers could be successfully treate …
In the present study, we first established a cell population from H1299, the p53-null non-small cell lung cancer cell line, by 10 Gy …
Loss of Rad51c leads to embryonic lethality and modulation of Trp53-dependent tumorigenesis in mice.
Kuznetsov SG, Haines DC, Martin BK, Sharan SK. Kuznetsov SG, et al. Cancer Res. 2009 Feb 1;69(3):863-72. doi: 10.1158/0008-5472.CAN-08-3057. Epub 2009 Jan 20. Cancer Res. 2009. PMID: 19155299 Free PMC article.
RecA/Rad51 protein family members (Rad51, Rad51b, Rad51c, Rad51d, Xrcc2, and Xrcc3) are essential for DNA repair by homologous recombination, and their role in cancers has been anticipated. Here we provide the first direct evidence for a tumor suppressor function fo …
RecA/Rad51 protein family members (Rad51, Rad51b, Rad51c, Rad51d, Xrcc2, and Xrcc3) are essential for DNA repair by homologous recomb …