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Page 1
A profile of fertilization in mammals.
Wassarman PM, Jovine L, Litscher ES. Wassarman PM, et al. Nat Cell Biol. 2001 Feb;3(2):E59-64. doi: 10.1038/35055178. Nat Cell Biol. 2001. PMID: 11175768 Review.
The pathway begins with species-specific binding of sperm to eggs and ends a relatively short time later with fusion of a single sperm with each egg. Although this process has been investigated extensively, only recently have the molecular compo …
The pathway begins with species-specific binding of sperm to eggs and ends a relatively short time later with fusion of a s …
Role of Ion Channels in the Sperm Acrosome Reaction.
Beltrán C, Treviño CL, Mata-Martínez E, Chávez JC, Sánchez-Cárdenas C, Baker M, Darszon A. Beltrán C, et al. Adv Anat Embryol Cell Biol. 2016;220:35-69. doi: 10.1007/978-3-319-30567-7_3. Adv Anat Embryol Cell Biol. 2016. PMID: 27194349 Review.
The acrosome reaction (AR) is a unique exocytotic process where the acrosome, a single membrane-delimited specialized organelle, overlying the nucleus in the sperm head of many species, fuses with the overlying plasma membrane. ...The AR is esse …
The acrosome reaction (AR) is a unique exocytotic process where the acrosome, a single membrane-delimited specialized organell …
Structural insights into tetraspanin CD9 function.
Umeda R, Satouh Y, Takemoto M, Nakada-Nakura Y, Liu K, Yokoyama T, Shirouzu M, Iwata S, Nomura N, Sato K, Ikawa M, Nishizawa T, Nureki O. Umeda R, et al. Nat Commun. 2020 Mar 30;11(1):1606. doi: 10.1038/s41467-020-15459-7. Nat Commun. 2020. PMID: 32231207 Free PMC article.
Here we report the crystal structure of CD9 and the cryo-electron microscopic structure of CD9 in complex with its single membrane-spanning partner protein, EWI-2. The reversed cone-like molecular shape of CD9 generates membrane curvature in the crystalline l …
Here we report the crystal structure of CD9 and the cryo-electron microscopic structure of CD9 in complex with its single membrane …
Molecular mechanisms of membrane fusion during acrosomal exocytosis.
Tomes CN. Tomes CN. Soc Reprod Fertil Suppl. 2007;65:275-91. Soc Reprod Fertil Suppl. 2007. PMID: 17644969 Review.
Luckily, sperm are not the exception to this rule. For instance, fusion of the outer acrosomal to the plasma membrane depends on Rab3 activation, alpha-SNAP/NSF, synaptotagmin, and SNAREs; it also requires an efflux of calcium from the acrosomal lumen. …
Luckily, sperm are not the exception to this rule. For instance, fusion of the outer acrosomal to the plasma membran …
Comparative proteomic analysis of seminal plasma exosomes in buffalo with high and low sperm motility.
Yu K, Xiao K, Sun QQ, Liu RF, Huang LF, Zhang PF, Xu HY, Lu YQ, Fu Q. Yu K, et al. BMC Genomics. 2023 Jan 9;24(1):8. doi: 10.1186/s12864-022-09106-2. BMC Genomics. 2023. PMID: 36624393 Free PMC article.
Many SPEs proteins originated from spermatozoa and SP, and nearly one third were also present in spermatozoa and SP. A series of proteins associated with reproductive processes including sperm capacitation, spermatid differentiation, fertilization, …
Many SPEs proteins originated from spermatozoa and SP, and nearly one third were also present in spermatozoa and SP. A series …
Sperm antigens in fertilization.
Saling PM. Saling PM. Immunol Allergy Clin North Am. 1990 Feb;10(1):149-64. Immunol Allergy Clin North Am. 1990. PMID: 12283429
A review of sperm antigens involved in fertilization includes a description of sperm differentiation, seminal fluid components that coat sperm, sperm antigens involved in binding to the zona pellucida (ZP), antigens involved …
A review of sperm antigens involved in fertilization includes a description of sperm differentiation, seminal fl …
ROLE OF THE GAMETE MEMBRANES IN FERTILIZATION IN SACCOGLOSSUS KOWALEVSKII (ENTEROPNEUSTA). II. ZYGOTE FORMATION BY GAMETE MEMBRANE FUSION.
COLWIN LH, COLWIN AL. COLWIN LH, et al. J Cell Biol. 1963 Dec;19(3):501-18. doi: 10.1083/jcb.19.3.501. J Cell Biol. 1963. PMID: 14086134 Free PMC article.
An earlier paper showed that in Saccoglossus the acrosomal tubule makes contact with the egg plasma membrane. The present paper includes evidence that the sperm and egg plasma membranes fuse to establish the single continuous zygot …
An earlier paper showed that in Saccoglossus the acrosomal tubule makes contact with the egg plasma membrane. The prese …
Cortically restricted production of IP3 leads to propagation of the fertilization Ca2+ wave along the cell surface in a model of the Xenopus egg.
Fall CP, Wagner JM, Loew LM, Nuccitelli R. Fall CP, et al. J Theor Biol. 2004 Dec 21;231(4):487-96. doi: 10.1016/j.jtbi.2004.06.019. J Theor Biol. 2004. PMID: 15488526
The fertilization Ca2+ wave in Xenopus laevis is a single, large wave of elevated free cytosolic Ca2+ concentration that emanates from the point of sperm-egg fusion and traverses the entire diameter of the egg. ...In this case, we find th …
The fertilization Ca2+ wave in Xenopus laevis is a single, large wave of elevated free cytosolic Ca2+ concentration that emana …
Dynamics of cortical granule exocytosis at fertilization in living mouse eggs.
Tahara M, Tasaka K, Masumoto N, Mammoto A, Ikebuchi Y, Miyake A. Tahara M, et al. Am J Physiol. 1996 May;270(5 Pt 1):C1354-61. doi: 10.1152/ajpcell.1996.270.5.C1354. Am J Physiol. 1996. PMID: 8967435
Sperm-egg fusion induces an intracellular free calcium concentration ([Ca2+]i) increase and exocytosis of cortical granules (CGs). Recently we used an impermeable fluorescent membrane probe, 1-[4-(trimethylammonio)phenyl]-6-phenyl-1,3,5-hexatriene (TMA …
Sperm-egg fusion induces an intracellular free calcium concentration ([Ca2+]i) increase and exocytosis of cortical gran …
Ubiquitin-activating enzyme E1 inhibitor PYR-41 retards sperm enlargement after fusion to the egg.
Yoshida K, Kang W, Nakamura A, Kawano N, Hanai M, Miyado M, Miyamoto Y, Iwai M, Hamatani T, Saito H, Miyado K, Umezawa A. Yoshida K, et al. Reprod Toxicol. 2018 Mar;76:71-77. doi: 10.1016/j.reprotox.2018.01.001. Epub 2018 Feb 3. Reprod Toxicol. 2018. PMID: 29355596
UBE-1 was detected by immunoblotting and immunocytochemistry in mouse eggs and was localized mainly under the egg plasma membrane. PYR-41 pretreatment suppresses the development of eggs into two-cell embryos. Specifically, pretreatment retarded sper …
UBE-1 was detected by immunoblotting and immunocytochemistry in mouse eggs and was localized mainly under the egg plasma me …
20 results