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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1949 1
1963 2
1964 1
1965 2
1968 3
1969 1
1970 2
1971 2
1972 1
1973 2
1974 3
1975 14
1976 13
1977 12
1978 10
1979 17
1980 18
1981 19
1982 27
1983 22
1984 26
1985 36
1986 35
1987 45
1988 42
1989 35
1990 71
1991 62
1992 72
1993 56
1994 65
1995 81
1996 78
1997 99
1998 90
1999 125
2000 114
2001 153
2002 169
2003 183
2004 216
2005 266
2006 294
2007 314
2008 336
2009 333
2010 380
2011 395
2012 476
2013 511
2014 541
2015 559
2016 529
2017 569
2018 638
2019 698
2020 783
2021 880
2022 887
2023 811
2024 277

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11,309 results

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Page 1
New Insights into Modes of GPCR Activation.
Wang W, Qiao Y, Li Z. Wang W, et al. Trends Pharmacol Sci. 2018 Apr;39(4):367-386. doi: 10.1016/j.tips.2018.01.001. Epub 2018 Jan 31. Trends Pharmacol Sci. 2018. PMID: 29395118 Review.
In classical G-protein-coupled receptor (GPCR) activation, GPCRs couple to a variety of heterotrimeric G proteins on the membrane and then activate downstream signaling pathways. ...Some novel modes of GPCR activation have been proposed to explain their compl …
In classical G-protein-coupled receptor (GPCR) activation, GPCRs couple to a variety of heterotrimeric G proteins on the membr …
Structural insights into emergent signaling modes of G protein-coupled receptors.
Sutkeviciute I, Vilardaga JP. Sutkeviciute I, et al. J Biol Chem. 2020 Aug 14;295(33):11626-11642. doi: 10.1074/jbc.REV120.009348. Epub 2020 Jun 22. J Biol Chem. 2020. PMID: 32571882 Free PMC article. Review.
GPCRs are characterized by a seven-transmembrane alpha-helical structure, transmitting extracellular signals into cells to regulate major physiological processes via heterotrimeric G proteins and beta-arrestins. Initially viewed as receptors whose signaling via G pr …
GPCRs are characterized by a seven-transmembrane alpha-helical structure, transmitting extracellular signals into cells to regulate major ph …
Low-frequency vibrational modes in G-quadruplexes reveal the mechanical properties of nucleic acids.
González-Jiménez M , Ramakrishnan G , Tukachev NV , Senn HM , Wynne K . González-Jiménez M , et al. Phys Chem Chem Phys. 2021 Jun 21;23(23):13250-13260. doi: 10.1039/d0cp05404f. Epub 2021 Jun 4. Phys Chem Chem Phys. 2021. PMID: 34095914 Free PMC article.
Contrary to expectation, we found that G-quadruplexes show several strongly underdamped delocalized phonon-like modes that have the potential to contribute to the biology of the DNA at the atomic level. In addition, G-quadruplexes present modes at a hi …
Contrary to expectation, we found that G-quadruplexes show several strongly underdamped delocalized phonon-like modes that hav …
COVID-19 and its Modes of Transmission.
Karia R, Gupta I, Khandait H, Yadav A, Yadav A. Karia R, et al. SN Compr Clin Med. 2020;2(10):1798-1801. doi: 10.1007/s42399-020-00498-4. Epub 2020 Sep 1. SN Compr Clin Med. 2020. PMID: 32904860 Free PMC article. Review.
Indirect transmission may occur via (1) fomites or surfaces (e.g., furniture and fixtures) present within the immediate environment of an infected patient and (2) objects used on the infected person (e.g., stethoscope or thermometer). As many of these modes m …
Indirect transmission may occur via (1) fomites or surfaces (e.g., furniture and fixtures) present within the immediate environment o …
The G-patch activators Pfa1 and PINX1 exhibit different modes of interaction with the Prp43 RNA helicase.
Mouffok S, Capeyrou R, Belhabich-Baumas K, Joret C, Henras AK, Humbert O, Henry Y. Mouffok S, et al. RNA Biol. 2021 Apr;18(4):510-522. doi: 10.1080/15476286.2020.1818458. Epub 2020 Oct 30. RNA Biol. 2021. PMID: 32882145 Free PMC article.
Its activities are directly stimulated by several co-activators that share a G-patch domain. The substrates of Prp43, its mechanism of action and the modes of interaction with and activation by G-patch proteins have been only partially characterized. ...We co …
Its activities are directly stimulated by several co-activators that share a G-patch domain. The substrates of Prp43, its mechanism o …
Naphthalene Diimides as Multimodal G-Quadruplex-Selective Ligands.
Pirota V, Nadai M, Doria F, Richter SN. Pirota V, et al. Molecules. 2019 Jan 24;24(3):426. doi: 10.3390/molecules24030426. Molecules. 2019. PMID: 30682828 Free PMC article. Review.
G-quadruplexes are four-stranded nucleic acids structures that can form in guanine-rich sequences. ...Their different binding modes (reversible versus irreversible/covalent) towards G-quadruplexes and their additional use as antimicrobial agents are also pres …
G-quadruplexes are four-stranded nucleic acids structures that can form in guanine-rich sequences. ...Their different binding mode …
Quantum control of bosonic modes with superconducting circuits.
Ma WL, Puri S, Schoelkopf RJ, Devoret MH, Girvin SM, Jiang L. Ma WL, et al. Sci Bull (Beijing). 2021 Sep 15;66(17):1789-1805. doi: 10.1016/j.scib.2021.05.024. Epub 2021 May 31. Sci Bull (Beijing). 2021. PMID: 36654386 Review.
Bosonic modes have wide applications in various quantum technologies, such as optical photons for quantum communication, magnons in spin ensembles for quantum information storage and mechanical modes for reversible microwave-to-optical quantum transduction. There is …
Bosonic modes have wide applications in various quantum technologies, such as optical photons for quantum communication, magnons in s …
The network structure of schema modes.
Aalbers G, Engels T, Haslbeck JMB, Borsboom D, Arntz A. Aalbers G, et al. Clin Psychol Psychother. 2021 Sep;28(5):1065-1078. doi: 10.1002/cpp.2577. Epub 2021 Mar 11. Clin Psychol Psychother. 2021. PMID: 33606318 Free PMC article.
From this perspective, schema modes mutually influence each other (e.g., healthy modes reduce dysfunctional modes). ...Results showed that, in both samples, the Healthy Adult was significantly less central than several dysfunctional modes (e. …
From this perspective, schema modes mutually influence each other (e.g., healthy modes reduce dysfunctional modes …
An Aesthetic Frame for Three Modes of Knowing.
Bao Y, Zhang D, Zhao C, Pöppel E, Zabotkina V. Bao Y, et al. Psych J. 2022 Oct;11(5):636-644. doi: 10.1002/pchj.588. Epub 2022 Sep 4. Psych J. 2022. PMID: 36058886
This is the claim: Human knowledge expresses itself in three different modes: explicit, implicit, and sensory (e.g., visual) knowledge. ...We suggest that a unifying frame of the modes of knowing lies in aesthetic principles. These different modes of k …
This is the claim: Human knowledge expresses itself in three different modes: explicit, implicit, and sensory (e.g., visual) k …
An in silico investigation of the binding modes and pathway of APTO-253 on c-KIT G-quadruplex DNA.
Pal S , Paul S . Pal S , et al. Phys Chem Chem Phys. 2021 Feb 7;23(5):3361-3376. doi: 10.1039/d0cp05210h. Epub 2021 Jan 27. Phys Chem Chem Phys. 2021. PMID: 33502401
From the cluster structure analysis, mainly three binding pathways i.e., top, bottom and side loop stacking modes are identified. Moreover, RMSD, RMSF and 2D-RMSD values indicate that the c-KIT G-quadruplex DNA and APTO-253 molecules are stable throughout the simula …
From the cluster structure analysis, mainly three binding pathways i.e., top, bottom and side loop stacking modes are identified. Mor …
11,309 results
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