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Page 1
Trauma-Induced Coagulopathy in Children.
Lucisano AC, Leeper CM, Gaines BA. Lucisano AC, et al. Among authors: gaines ba. Semin Thromb Hemost. 2020 Mar;46(2):147-154. doi: 10.1055/s-0040-1702203. Epub 2020 Mar 11. Semin Thromb Hemost. 2020. PMID: 32160641 Review.
Trauma-induced coagulopathy (TIC) is well documented in injured children. However, many important features of pediatric hemostasis are still in development in early childhood and may impact TIC. ...
Trauma-induced coagulopathy (TIC) is well documented in injured children. However, many important features of pediatric hemostasis ar …
Use of whole blood in pediatric trauma: a narrative review.
Abou Khalil E, Morgan KM, Gaines BA, Spinella PC, Leeper CM. Abou Khalil E, et al. Among authors: gaines ba. Trauma Surg Acute Care Open. 2024 Jan 5;9(Suppl 1):e001127. doi: 10.1136/tsaco-2023-001127. eCollection 2024. Trauma Surg Acute Care Open. 2024. PMID: 38196932 Free PMC article. Review.
Balanced hemostatic resuscitation has been associated with improved outcomes in patients with both pediatric and adult trauma. Cold-stored, low-titer group O whole blood (LTOWB) has been increasingly used as a primary resuscitation product in trauma in recent years. ...Rep …
Balanced hemostatic resuscitation has been associated with improved outcomes in patients with both pediatric and adult trauma. Cold-stored, …
Fibrinolysis Shutdown in Trauma: Historical Review and Clinical Implications.
Moore HB, Moore EE, Neal MD, Sheppard FR, Kornblith LZ, Draxler DF, Walsh M, Medcalf RL, Cohen MJ, Cotton BA, Thomas SG, Leeper CM, Gaines BA, Sauaia A. Moore HB, et al. Among authors: gaines ba. Anesth Analg. 2019 Sep;129(3):762-773. doi: 10.1213/ANE.0000000000004234. Anesth Analg. 2019. PMID: 31425218 Free PMC article. Review.
Patterns of trauma-induced coagulopathy in injured children: A principal component analysis investigating endothelial, coagulation, and platelet biomarkers.
Morgan KM, Feeney EV, Spinella PC, Gaines BA, Leeper CM. Morgan KM, et al. Among authors: gaines ba. J Trauma Acute Care Surg. 2025 Jan 1;98(1):36-41. doi: 10.1097/TA.0000000000004501. Epub 2024 Nov 20. J Trauma Acute Care Surg. 2025. PMID: 39690462
BACKGROUND: Trauma-induced coagulopathy is common and associated with poor outcomes in injured children. Our aim was to identify patterns of coagulopathy after injury using endothelial, platelet, and coagulation biomarkers, and associate these phenotypes with …
BACKGROUND: Trauma-induced coagulopathy is common and associated with poor outcomes in injured children. Our aim was to identify patt …
Resuscitative practices and the use of low-titer group O whole blood in pediatric trauma.
Morgan KM, Leeper CM, Yazer MH, Spinella PC, Gaines BA. Morgan KM, et al. Among authors: gaines ba. J Trauma Acute Care Surg. 2023 Jan 1;94(1S Suppl 1):S29-S35. doi: 10.1097/TA.0000000000003801. Epub 2022 Sep 26. J Trauma Acute Care Surg. 2023. PMID: 36156051
Recent data support shifting away from crystalloid and toward early resuscitation with blood products because of worse coagulopathy and clinical outcomes in injured patients resuscitated with crystalloid. ...Low risks of hemolytic disease of the fetus and newborn af …
Recent data support shifting away from crystalloid and toward early resuscitation with blood products because of worse coagulopath
Acute traumatic coagulopathy in a critically injured pediatric population: Definition, trend over time, and outcomes.
Leeper CM, Kutcher M, Nasr I, McKenna C, Billiar T, Neal M, Sperry J, Gaines BA. Leeper CM, et al. Among authors: gaines ba. J Trauma Acute Care Surg. 2016 Jul;81(1):34-41. doi: 10.1097/TA.0000000000001002. J Trauma Acute Care Surg. 2016. PMID: 26886002
BACKGROUND: While our understanding of acute traumatic coagulopathy (ATC) in adults is advancing, the pediatric literature on ATC is limited. Children have a unique injury profile and physiologic response to trauma; however, the impact of this phenomenon on ATC has not bee …
BACKGROUND: While our understanding of acute traumatic coagulopathy (ATC) in adults is advancing, the pediatric literature on ATC is …
Principal component analysis of coagulation assays in severely injured children.
Leeper CM, Neal MD, McKenna C, Billiar T, Gaines BA. Leeper CM, et al. Among authors: gaines ba. Surgery. 2018 Apr;163(4):827-831. doi: 10.1016/j.surg.2017.09.031. Epub 2017 Dec 13. Surgery. 2018. PMID: 29248181 Clinical Trial.
BACKGROUND: Trauma-induced coagulopathy is common and associated with poor outcome in injured children. Our aim is to identify patterns of coagulation dysregulation after injury and associate these phenotypes with relevant clinical outcomes. ...PC3 score was associa …
BACKGROUND: Trauma-induced coagulopathy is common and associated with poor outcome in injured children. Our aim is to identify patter …
Admission maximum amplitude-reaction time ratio: Association between thromboelastography values predicts poor outcome in injured children.
Abou Khalil E, Gaines BA, Morgan KM, Leeper CM. Abou Khalil E, et al. Among authors: gaines ba. J Trauma Acute Care Surg. 2023 Feb 1;94(2):212-219. doi: 10.1097/TA.0000000000003834. Epub 2022 Nov 15. J Trauma Acute Care Surg. 2023. PMID: 36694332
INTRODUCTION: Thromboelastography (TEG)-derived maximum amplitude-reaction time (MA-R) ratio that accounts for both hypocoagulable and hypercoagulable changes in coagulation is associated with poor outcomes in adults. The relationship between these TEG values and outcomes …
INTRODUCTION: Thromboelastography (TEG)-derived maximum amplitude-reaction time (MA-R) ratio that accounts for both hypocoagulable and hyper …
Sex dimorphisms in coagulation characteristics in the pediatric trauma population appear after puberty.
Hrebinko KA, Strotmeyer S, Richardson W, Gaines BA, Leeper CM. Hrebinko KA, et al. Among authors: gaines ba. J Trauma Acute Care Surg. 2022 Apr 1;92(4):675-682. doi: 10.1097/TA.0000000000003508. J Trauma Acute Care Surg. 2022. PMID: 34936590
BACKGROUND: The role of age and sex in mediating coagulation characteristics in injured children is not well defined. We hypothesize that thromboelastography (TEG) profiles are equivalent across sex in younger children and diverge after puberty. ...This interaction persist …
BACKGROUND: The role of age and sex in mediating coagulation characteristics in injured children is not well defined. We hypothesize …
Endotheliopathy of trauma in children: The association of syndecan-1 with injury and poor outcomes.
Morgan KM, Abou-Khalil E, Gaines BA, Leeper CM. Morgan KM, et al. Among authors: gaines ba. J Trauma Acute Care Surg. 2024 Apr 1;96(4):566-572. doi: 10.1097/TA.0000000000004229. Epub 2023 Dec 8. J Trauma Acute Care Surg. 2024. PMID: 38079262
BACKGROUND: The contribution of the endothelium to trauma-induced coagulopathy has not been thoroughly investigated in injured children. METHODS: This is a prospective cohort study of children (younger than 18 years) who presented with a potentially severe injury to an aca …
BACKGROUND: The contribution of the endothelium to trauma-induced coagulopathy has not been thoroughly investigated in injured childr …
16 results