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Page 1
Galectin-3 and the skin.
Larsen L, Chen HY, Saegusa J, Liu FT. Larsen L, et al. J Dermatol Sci. 2011 Nov;64(2):85-91. doi: 10.1016/j.jdermsci.2011.07.008. Epub 2011 Aug 11. J Dermatol Sci. 2011. PMID: 21889881 Free PMC article. Review.
Galectin-3 is detected at different stages of melanoma development. ...Galectin-3 may be a novel therapeutic target for a variety of skin diseases....
Galectin-3 is detected at different stages of melanoma development. ...Galectin-3 may be a novel therapeu …
Galectin-3 regulation of wound healing and fibrotic processes: insights for chronic skin wound therapeutics.
McLeod K, Walker JT, Hamilton DW. McLeod K, et al. J Cell Commun Signal. 2018 Mar;12(1):281-287. doi: 10.1007/s12079-018-0453-7. Epub 2018 Jan 25. J Cell Commun Signal. 2018. PMID: 29372416 Free PMC article. Review.
However, it appears that many of the effects of Galectin-3 are highly tissue specific and context dependent. Genetic deletion of galectin-3 shows different effects in skin compared to lung, heart, and kidney remodeling. In this review, we will c …
However, it appears that many of the effects of Galectin-3 are highly tissue specific and context dependent. Genetic deletion …
Increased Expression of Galectin-3 in Skin Fibrosis: Evidence from In Vitro and In Vivo Studies.
Peiró T, Alonso-Carpio M, Ribera P, Almudéver P, Roger I, Montero P, Marín S, Milara J, Cortijo J. Peiró T, et al. Int J Mol Sci. 2022 Dec 5;23(23):15319. doi: 10.3390/ijms232315319. Int J Mol Sci. 2022. PMID: 36499646 Free PMC article.
Galectin-3 (GAL-3) has emerged as a central regulator of tissue fibrosis, playing an important pro-fibrotic role in numerous organs. ...This paper aims to ascertain whether the expression of GAL-3 is increased in relevant in vitro and in vivo models of …
Galectin-3 (GAL-3) has emerged as a central regulator of tissue fibrosis, playing an important pro-fibrotic role in num …
Galectin-3 Expression in Benign and Malignant Skin Diseases With Epidermal Hyperplasia.
Jiang ZX, Tan GZ, Shi ZR, Zhang YP, Han YF, Wang L. Jiang ZX, et al. Am J Dermatopathol. 2017 Oct;39(10):738-741. doi: 10.1097/DAD.0000000000000781. Am J Dermatopathol. 2017. PMID: 27922892
Galectin-3 has been suggested relative to tumor genesis, progression, and metastasis in basal cell carcinoma and squamous cell carcinoma that are the most common skin cancers characterized by malignant epidermal proliferation. ...We found that galectin …
Galectin-3 has been suggested relative to tumor genesis, progression, and metastasis in basal cell carcinoma and squamous cell …
Galectin-1 and Galectin-3 Expression in Lesional Skin of Patients With Systemic Sclerosis-Association With Disease Severity.
Mora GF, Zubieta MR. Mora GF, et al. J Clin Rheumatol. 2021 Dec 1;27(8):317-323. doi: 10.1097/RHU.0000000000001367. J Clin Rheumatol. 2021. PMID: 32501939
Galectin-1 (Gal-1) and galectin-3 (Gal-3) are carbohydrate-binding proteins involved in normal processes, autoimmunity, and cancer. ...A higher Gal-3 expression in scleroderma (within its lower expression compared with normal skin) was as …
Galectin-1 (Gal-1) and galectin-3 (Gal-3) are carbohydrate-binding proteins involved in normal processes, autoim …
Association of galectin-3 expression with melanoma progression and prognosis.
Brown ER, Doig T, Anderson N, Brenn T, Doherty V, Xu Y, Bartlett JM, Smyth JF, Melton DW. Brown ER, et al. Eur J Cancer. 2012 Apr;48(6):865-74. doi: 10.1016/j.ejca.2011.09.003. Epub 2011 Nov 7. Eur J Cancer. 2012. PMID: 22071132
To investigate the role of galectin-3 in melanoma pathogenesis we examined the expression of galectin-3 in melanocytic lesions and analysed the correlation between galectin-3 expression and clinicopathologic factors including patie …
To investigate the role of galectin-3 in melanoma pathogenesis we examined the expression of galectin-3 i …
Galectin-3 contributes to melanoma growth and metastasis via regulation of NFAT1 and autotaxin.
Braeuer RR, Zigler M, Kamiya T, Dobroff AS, Huang L, Choi W, McConkey DJ, Shoshan E, Mobley AK, Song R, Raz A, Bar-Eli M. Braeuer RR, et al. Cancer Res. 2012 Nov 15;72(22):5757-66. doi: 10.1158/0008-5472.CAN-12-2424. Epub 2012 Sep 17. Cancer Res. 2012. PMID: 22986745 Free PMC article.
We have previously shown that silencing galectin-3 in metastatic melanoma cells reduces tumor growth and metastasis. ...Reexpression of autotaxin in galectin-3 silenced melanoma cells rescues angiogenesis, tumor growth, and metastasis in …
We have previously shown that silencing galectin-3 in metastatic melanoma cells reduces tumor growth and metastasis. .. …
Galectin 3: an extraordinary multifunctional protein in dermatology. Current knowledge and perspectives.
Pasmatzi E, Papadionysiou C, Monastirli A, Badavanis G, Tsambaos D. Pasmatzi E, et al. An Bras Dermatol. 2019 Jul 29;94(3):348-354. doi: 10.1590/abd1806-4841.20198426. An Bras Dermatol. 2019. PMID: 31365668 Free PMC article. Review.
Galectin 3 is a unique ~31 kDa protein that recognizes the N-acetyl-lactosamine structure of several glycoconjugates. ...In this paper the authors summarize current knowledge on the expression of galectin 3 in normal and diseased human skin, its …
Galectin 3 is a unique ~31 kDa protein that recognizes the N-acetyl-lactosamine structure of several glycoconjugates. ...In th …
αvβ1 integrin is enriched in extracellular vesicles of metastatic breast cancer cells: A mechanism mediated by galectin-3.
Zhang DX, Dang XTT, Vu LT, Lim CMH, Yeo EYM, Lam BWS, Leong SM, Omar N, Putti TC, Yeh YC, Ma V, Luo JY, Cho WC, Chen G, Lee VKM, Grimson A, Le MTN. Zhang DX, et al. J Extracell Vesicles. 2022 Aug;11(8):e12234. doi: 10.1002/jev2.12234. J Extracell Vesicles. 2022. PMID: 35923105 Free PMC article.
In particular, knockdown of galectin-3, but not galectin-1, causes a reduction in the levels of cell surface integrins beta1 and alphav, and decreases the colocalization of these integrins with CD63. Importantly, knockdown of galectin-3 leads to …
In particular, knockdown of galectin-3, but not galectin-1, causes a reduction in the levels of cell surface integrins …
Expression Pattern and Immunoregulatory Roles of Galectin-1 and Galectin-3 in Atopic Dermatitis and Psoriasis.
Corrêa MP, Correia-Silva RD, Sasso GRS, D'Ávila SCGP, Greco KV, Oliani SM, Gil CD. Corrêa MP, et al. Inflammation. 2022 Jun;45(3):1133-1145. doi: 10.1007/s10753-021-01608-7. Epub 2022 Jan 15. Inflammation. 2022. PMID: 35031944
Here, we evaluated galectin (Gal)-1 and Gal-3 levels, which are beta-galactoside-binding proteins with immunomodulatory functions and examined their effects on human keratinocytes stimulated with either interleukin (IL)-4 or IL-17A. ...Protein and mRNA Gal-3 …
Here, we evaluated galectin (Gal)-1 and Gal-3 levels, which are beta-galactoside-binding proteins with immunomodulatory functi …
164 results