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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1995 1
1998 1
2000 3
2001 4
2002 3
2003 5
2004 3
2005 3
2006 4
2007 2
2008 3
2009 2
2010 6
2011 6
2012 9
2013 18
2014 25
2015 29
2016 32
2017 26
2018 26
2019 37
2020 48
2021 46
2022 27
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317 results
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Page 1
Current and future pharmacological therapies for NAFLD/NASH.
Sumida Y, Yoneda M. Sumida Y, et al. J Gastroenterol. 2018 Mar;53(3):362-376. doi: 10.1007/s00535-017-1415-1. Epub 2017 Dec 16. J Gastroenterol. 2018. PMID: 29247356 Free PMC article. Review.
GLP-1RA and SGLT2 inhibitors, which are currently approved for use in diabetes, have shown early efficacy in NASH, and also have beneficial cardiovascular or renal effects. ...Antifibrotic agents are a cysteine-cysteine motif chemokine receptor-2/5 antagonist (cenicriviroc …
GLP-1RA and SGLT2 inhibitors, which are currently approved for use in diabetes, have shown early efficacy in NASH, and also have bene …
Galectin-3 Activation and Inhibition in Heart Failure and Cardiovascular Disease: An Update.
Suthahar N, Meijers WC, Silljé HHW, Ho JE, Liu FT, de Boer RA. Suthahar N, et al. Theranostics. 2018 Jan 1;8(3):593-609. doi: 10.7150/thno.22196. eCollection 2018. Theranostics. 2018. PMID: 29344292 Free PMC article. Review.
In the last decade, considerable interest in galectin-3 has emerged because of its potential role as a biotarget. ...Galectin-3 overexpression and secretion is associated with several diseases and is extensively studied in the context of fibrosis, hear …
In the last decade, considerable interest in galectin-3 has emerged because of its potential role as a biotarget. ...Galect
Chitinase-3 like-protein-1 function and its role in diseases.
Zhao T, Su Z, Li Y, Zhang X, You Q. Zhao T, et al. Signal Transduct Target Ther. 2020 Sep 14;5(1):201. doi: 10.1038/s41392-020-00303-7. Signal Transduct Target Ther. 2020. PMID: 32929074 Free PMC article. Review.
Non-enzymatic chitinase-3 like-protein-1 (CHI3L1) belongs to glycoside hydrolase family 18. ...To date, interleukin-13 receptor subunit alpha-2, transmembrane protein 219, galectin-3, chemo-attractant receptor-homologous 2, and CD44 have been identified as CH …
Non-enzymatic chitinase-3 like-protein-1 (CHI3L1) belongs to glycoside hydrolase family 18. ...To date, interleukin-13 receptor subun …
Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance.
Li P, Liu S, Lu M, Bandyopadhyay G, Oh D, Imamura T, Johnson AMF, Sears D, Shen Z, Cui B, Kong L, Hou S, Liang X, Iovino S, Watkins SM, Ying W, Osborn O, Wollam J, Brenner M, Olefsky JM. Li P, et al. Cell. 2016 Nov 3;167(4):973-984.e12. doi: 10.1016/j.cell.2016.10.025. Cell. 2016. PMID: 27814523 Free PMC article.
In obesity, macrophages and other immune cells accumulate in insulin target tissues, promoting a chronic inflammatory state and insulin resistance. Galectin-3 (Gal3), a lectin mainly secreted by macrophages, is elevated in both obese subjects and mice. ...
In obesity, macrophages and other immune cells accumulate in insulin target tissues, promoting a chronic inflammatory state and insulin resi …
Association of circulating galectin-3 with gestational diabetes mellitus, progesterone, and insulin resistance.
Zhang Z, Kang X, Guo Y, Zhang J, Xie J, Shao S, Xiang Y, Chen G, Yu X. Zhang Z, et al. J Diabetes. 2021 Jan;13(1):54-62. doi: 10.1111/1753-0407.13088. Epub 2020 Sep 2. J Diabetes. 2021. PMID: 32671973
BACKGROUND/OBJECTIVE: Because galectin-3 has been proposed to regulate obesity and insulin resistance in mice, we hypothesized that circulating galectin-3 levels are associated with presence of gestational diabetes mellitus (GDM), progest …
BACKGROUND/OBJECTIVE: Because galectin-3 has been proposed to regulate obesity and insulin resistance in mice, we hypothesized …
Galectin-3 and S100A9: Novel Diabetogenic Factors Mediating Pancreatic Cancer-Associated Diabetes.
Liao WC, Huang BS, Yu YH, Yang HH, Chen PR, Huang CC, Huang HY, Wu MS, Chow LP. Liao WC, et al. Diabetes Care. 2019 Sep;42(9):1752-1759. doi: 10.2337/dc19-0217. Epub 2019 Jul 1. Diabetes Care. 2019. PMID: 31262951
In the training set, serum galectin-3 and S100A9 levels were exclusively increased in patients with PCDM and distinguished PCDM from type 2 diabetes (area under the curve [AUC] galectin-3: 0.73 [95% CI 0.64-0.83]; S100A9: 0.79 [95% CI 0.70-0.87] …
In the training set, serum galectin-3 and S100A9 levels were exclusively increased in patients with PCDM and distinguished PCD …
Emerging roles of Galectin-3 in diabetes and diabetes complications: A snapshot.
Li Y, Li T, Zhou Z, Xiao Y. Li Y, et al. Rev Endocr Metab Disord. 2022 Jun;23(3):569-577. doi: 10.1007/s11154-021-09704-7. Epub 2022 Jan 27. Rev Endocr Metab Disord. 2022. PMID: 35083706 Free PMC article. Review.
We summarized the roles of Galectin-3 in diabetes and its complications, as well as the underlying mechanisms. Clinical research has determined that the circulating level of Galectin-3 is closely related to diabetes and its complications, …
We summarized the roles of Galectin-3 in diabetes and its complications, as well as the underlying mechanisms. Clinical …
Galectin-3 and risk of cardiovascular events and all-cause mortality in type 2 diabetes.
Tan KCB, Cheung CL, Lee ACH, Lam JKY, Wong Y, Shiu SWM. Tan KCB, et al. Diabetes Metab Res Rev. 2019 Feb;35(2):e3093. doi: 10.1002/dmrr.3093. Epub 2018 Nov 15. Diabetes Metab Res Rev. 2019. PMID: 30378236
Experimental data suggest that galectin-3 may play a role in atherogenesis. We have evaluated whether serum galectin-3 level is associated with cardiovascular outcome in type 2 diabetes. MATERIALS AND METHODS: Galectin-3 was measur …
Experimental data suggest that galectin-3 may play a role in atherogenesis. We have evaluated whether serum galectin- …
Berberine alleviates oxidized low-density lipoprotein-induced macrophage activation by downregulating galectin-3 via the NF-κB and AMPK signaling pathways.
Pei C, Zhang Y, Wang P, Zhang B, Fang L, Liu B, Meng S. Pei C, et al. Phytother Res. 2019 Feb;33(2):294-308. doi: 10.1002/ptr.6217. Epub 2018 Nov 6. Phytother Res. 2019. PMID: 30402951 Free PMC article. Clinical Trial.
Galectin-3 expression was measured by real-time PCR, Western blotting, and confocal microscopy. ...BBR suppressed ox-LDL-induced upregulation of galectin-3 and macrophage activation. Overexpression of galectin-3 intervened the inhibitory
Galectin-3 expression was measured by real-time PCR, Western blotting, and confocal microscopy. ...BBR suppressed ox-LDL-induc
Serum Galectin-3 and Subsequent Risk of Coronary Heart Disease in Subjects With Childhood-Onset Type 1 Diabetes: A Cohort Study.
Saeed M, Tapia G, Ariansen I, Stene LC, Seljeflot I, Tell GS, Skrivarhaug T, Joner G. Saeed M, et al. Diabetes Care. 2021 Mar;44(3):810-816. doi: 10.2337/dc20-1712. Epub 2021 Jan 6. Diabetes Care. 2021. PMID: 33408220 Free PMC article.
OBJECTIVE: To study whether serum galectin-3 and other biomarkers of inflammation predict coronary heart disease (CHD) in subjects with long-standing childhood-onset type 1 diabetes. ...CONCLUSIONS: Galectin-3 was significantly associated with f …
OBJECTIVE: To study whether serum galectin-3 and other biomarkers of inflammation predict coronary heart disease (CHD) in subj …
317 results