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331 results
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Page 1
Current and future pharmacological therapies for NAFLD/NASH.
Sumida Y, Yoneda M. Sumida Y, et al. J Gastroenterol. 2018 Mar;53(3):362-376. doi: 10.1007/s00535-017-1415-1. Epub 2017 Dec 16. J Gastroenterol. 2018. PMID: 29247356 Free PMC article. Review.
GLP-1RA and SGLT2 inhibitors, which are currently approved for use in diabetes, have shown early efficacy in NASH, and also have beneficial cardiovascular or renal effects. Innovative NASH therapies include four main pathways. ...Antifibrotic agents are a cysteine-cysteine …
GLP-1RA and SGLT2 inhibitors, which are currently approved for use in diabetes, have shown early efficacy in NASH, and also have beneficial …
Twist1 regulates macrophage plasticity to promote renal fibrosis through galectin-3.
Wu Q, Sun S, Wei L, Liu M, Liu H, Liu T, Zhou Y, Jia Q, Wang D, Yang Z, Duan M, Yang X, Gao P, Ning X. Wu Q, et al. Cell Mol Life Sci. 2022 Feb 19;79(3):137. doi: 10.1007/s00018-022-04137-0. Cell Mol Life Sci. 2022. PMID: 35182235 Free PMC article.
Ablation of Twist1 in macrophages markedly alleviated renal tubular injury and renal fibrosis in UUO mice, accompanied by a lower extent of macrophage infiltration and M2 polarization in the kidney. ...Up-regulation of galectin-3 recovered Twist …
Ablation of Twist1 in macrophages markedly alleviated renal tubular injury and renal fibrosis in UUO mice, accompanied by a lo …
Biomarkers for the diagnosis and management of heart failure.
Castiglione V, Aimo A, Vergaro G, Saccaro L, Passino C, Emdin M. Castiglione V, et al. Heart Fail Rev. 2022 Mar;27(2):625-643. doi: 10.1007/s10741-021-10105-w. Epub 2021 Apr 14. Heart Fail Rev. 2022. PMID: 33852110 Free PMC article. Review.
Other biomarkers evaluated as predictors of adverse outcome are galectin-3, growth differentiation factor 15, mid-regional pro-adrenomedullin, and makers of renal dysfunction. ...
Other biomarkers evaluated as predictors of adverse outcome are galectin-3, growth differentiation factor 15, mid-regional pro …
Galectin-3 Activation and Inhibition in Heart Failure and Cardiovascular Disease: An Update.
Suthahar N, Meijers WC, Silljé HHW, Ho JE, Liu FT, de Boer RA. Suthahar N, et al. Theranostics. 2018 Jan 1;8(3):593-609. doi: 10.7150/thno.22196. eCollection 2018. Theranostics. 2018. PMID: 29344292 Free PMC article. Review.
Galectin-3 is a versatile protein orchestrating several physiological and pathophysiological processes in the human body. In the last decade, considerable interest in galectin-3 has emerged because of its potential role as a biotarget. ...
Galectin-3 is a versatile protein orchestrating several physiological and pathophysiological processes in the human body. In t …
Therapeutic Targets for Heart Failure Identified Using Proteomics and Mendelian Randomization.
Henry A, Gordillo-Marañón M, Finan C, Schmidt AF, Ferreira JP, Karra R, Sundström J, Lind L, Ärnlöv J, Zannad F, Mälarstig A, Hingorani AD, Lumbers RT; HERMES and SCALLOP Consortia. Henry A, et al. Circulation. 2022 Apr 19;145(16):1205-1217. doi: 10.1161/CIRCULATIONAHA.121.056663. Epub 2022 Mar 18. Circulation. 2022. PMID: 35300523 Free PMC article.
Among these, 8 proteins had evidence of a causal association with HF that was robust to multiverse sensitivity analysis: higher CSF-1 (macrophage colony-stimulating factor 1), Gal-3 (galectin-3) and KIM-1 (kidney injury molecule 1) were positively asso …
Among these, 8 proteins had evidence of a causal association with HF that was robust to multiverse sensitivity analysis: higher CSF-1 (macro …
Mesenchymal stem cells ameliorate renal fibrosis by galectin-3/Akt/GSK3β/Snail signaling pathway in adenine-induced nephropathy rat.
Tang H, Zhang P, Zeng L, Zhao Y, Xie L, Chen B. Tang H, et al. Stem Cell Res Ther. 2021 Jul 16;12(1):409. doi: 10.1186/s13287-021-02429-z. Stem Cell Res Ther. 2021. PMID: 34271976 Free PMC article.
CONCLUSION: The mechanism of MSCs anti-renal fibrosis was probably mediated by galectin-3/Akt/GSK3beta/Snail signaling pathway. Galectin-3 may be a valuable target for treating renal fibrosis....
CONCLUSION: The mechanism of MSCs anti-renal fibrosis was probably mediated by galectin-3/Akt/GSK3beta/Snail signaling …
Cardiac biomarkers of heart failure in chronic kidney disease.
Han X, Zhang S, Chen Z, Adhikari BK, Zhang Y, Zhang J, Sun J, Wang Y. Han X, et al. Clin Chim Acta. 2020 Nov;510:298-310. doi: 10.1016/j.cca.2020.07.040. Epub 2020 Jul 23. Clin Chim Acta. 2020. PMID: 32710942 Review.
Heart failure remains a continuing threat to patients with chronic kidney disease (CKD). Although various heart failure biomarkers have been applied for early detection, diagnosis and prognosis in CKD, these are easily affected by renal insufficiency thus limiting u …
Heart failure remains a continuing threat to patients with chronic kidney disease (CKD). Although various heart failure biomarkers ha …
Novel Biomarkers of Heart Failure.
Savic-Radojevic A, Pljesa-Ercegovac M, Matic M, Simic D, Radovanovic S, Simic T. Savic-Radojevic A, et al. Adv Clin Chem. 2017;79:93-152. doi: 10.1016/bs.acc.2016.09.002. Epub 2016 Nov 3. Adv Clin Chem. 2017. PMID: 28212715 Review.
In this review, seven groups of biomarkers associated to myocardial stretch (mid-regional proatrial natriuretic peptide, MR-proANP), myocyte injury (high-sensitive troponins, hs-cTn; heart-type fatty acid-binding protein, H-FABP; glutathione transferase P1, GSTP1), matrix remodel …
In this review, seven groups of biomarkers associated to myocardial stretch (mid-regional proatrial natriuretic peptide, MR-proANP), myocyte …
Urinary Galectin-3 as a Novel Biomarker for the Prediction of Renal Fibrosis and Kidney Disease Progression.
Ou SM, Tsai MT, Chen HY, Li FA, Lee KH, Tseng WC, Chang FP, Lin YP, Yang RB, Tarng DC. Ou SM, et al. Biomedicines. 2022 Mar 2;10(3):585. doi: 10.3390/biomedicines10030585. Biomedicines. 2022. PMID: 35327386 Free PMC article.
Plasma galectin-3 (Gal-3) is associated with organ fibrosis, but whether urinary Gal-3 is a potential biomarker of kidney disease progression has never been explored. ...The urinary Gal-3 level may be useful for the identification of pati …
Plasma galectin-3 (Gal-3) is associated with organ fibrosis, but whether urinary Gal-3 is a potential biomarker …
Galectin-3 in Kidney Diseases: From an Old Protein to a New Therapeutic Target.
Boutin L, Dépret F, Gayat E, Legrand M, Chadjichristos CE. Boutin L, et al. Int J Mol Sci. 2022 Mar 14;23(6):3124. doi: 10.3390/ijms23063124. Int J Mol Sci. 2022. PMID: 35328545 Free PMC article. Review.
Galectin-3 (Gal-3) is a 30KDa lectin implicated in multiple pathophysiology pathways including renal damage and fibrosis. ...Moreover, Gal-3 has also been linked to kidney disease in both preclinical models and clinical studies. ...
Galectin-3 (Gal-3) is a 30KDa lectin implicated in multiple pathophysiology pathways including renal damage and …
331 results